Are We Practicing What We Are Taught in Health Professions’ Education? Coproducing Health Care

Health-care providers and educators are inherently empathetic, compassionate, experienced professionals who entered their profession to assure the complementary missions of public health and health care. These missions work to ensure conditions in which people can be healthy via disease and injury prevention, health promotion, and timely, effective, coordinated care (1). The skills necessary to achieve these crucial outcomes (ie, listening to the patient and their family, exhibiting empathy, and understanding the significance of the social determinants of health, etc) are routinely taught in health professions’ education. To highlight the necessity for these representative competencies covered throughout the course of health professions’ education, the personal experience of one of the author’s children is reported as a narration. The purpose of communicating this patient experience is to remind health-care providers: (a) about the importance of not only listening but hearing the parents of our patients and the patients themselves, (b) to actively practice the art and skill of empathy as the health-care setting can be overwhelming for patients and their families, and (c) to consider the impact of the social determinants of health on one’s health status to date. This 5-part patient experience serves to strengthen our commitment to assure that we practice what we are taught with the goal to coproduce health with our patients and their families

Toward Supergravity Spectral Action

A spectral action of Euclidean supergravity is proposed. We calculate up to $a_4$, the Seeley-Dewitt coefficients in the expansion of the spectral action associated to the supergravity Dirac operator. This is possible because in simple supergravity, as in pure gravity, a well defined and mathematically consistent Dirac operator can be constructed.Comment: 10pages, no figures, matches published versio

Static-light mesons on a dynamical anisotropic lattice

We present results for the spectrum of static-light mesons from Nf=2 lattice QCD. These results were obtained using all-to-all light quark propagators on an anisotropic lattice, yielding an improved signal resolution when compared to more conventional lattice techniques. In particular, we consider the inversion of orbitally-excited multiplets with respect to the `standard ordering', which has been predicted by some quark models.Comment: 3 pages with 3 figures. Talk by JF at "Quarks and Nuclear Physics", Madrid 5th-10th June 200

Locally Homogeneous Spaces, Induced Killing Vector Fields and Applications to Bianchi Prototypes

An answer to the question: Can, in general, the adoption of a given symmetry induce a further symmetry, which might be hidden at a first level? has been attempted in the context of differential geometry of locally homogeneous spaces. Based on E. Cartan's theory of moving frames, a methodology for finding all symmetries for any n dimensional locally homogeneous space is provided. The analysis is applied to 3 dimensional spaces, whereby the embedding of them into a 4 dimensional Lorentzian manifold is examined and special solutions to Einstein's field equations are recovered. The analysis is mainly of local character, since the interest is focused on local structures based on differential equations (and their symmetries), rather than on the implications of, e.g., the analytic continuation of their solution(s) and their dynamics in the large.Comment: 27 pages, no figues, no tables, one reference added, spelling and punctuation issues correcte

Urea Concentration and Hsp70 Expression in the Kidney of Thirteen-lined Ground Squirrels during Diuresis and Antidiuresis

During bouts of torpor hibernating animals have greatly reduced metabolic rates leading to profound decreases in body temperature and blood pressure. As a result of these conditions, kidney filtration and the ability to concentrate urine cease. Once a week, however, hibernators rewarm to euthermic body temperatures and regain kidney function. This is associated with rapid changes in extracellular osmotic gradients within the kidney, a remarkable feat but one that is potentially damaging to kidney cells. While hibernators deal with this stress by up-regulating expression of heat shock proteins (HSP’s) and protective organic osmolytes, little research has been done to see if hibernating animals can achieve and cope with similar situations during the summer. To address this question we placed a typical hibernator (I. tridecemlineatus) on various water intake regimes over the summer to experimentally manipulate vertical osmotic gradients in the kidney, represented by changes in urea concentration. We then measured renal expression of HSP 70 in response to changes in the vertical gradient. Animals rapidly altered the vertical gradients in their kidneys in response to different water intake regimes. This was accompanied by large changes in urine volume and concentration, and maintenance of serum hydromineral homeostasis. Unlike hibernation however, HSP70 expression was up-regulated in response to loss, rather than gain, of vertical osmotic gradients. This difference may be due to an interplay between HSP70 and protective organic osmolytes. Future studies will examine this relationship in closer detail and also evaluate the response of non-hibernating species to similar conditions

Duality Symmetry in Kaluza-Klein n+D+dn+D+d Dimensional Cosmological Model

It is shown that, with the only exception of $n=2$, the Einstein-Hilbert action in $n+D+d$ dimensions, with $n$ times, is invariant under the duality transformation $a\to \frac{1}{a}$ and $b\to \frac{1}{b}$, where $a$ is a Friedmann-Robertson-Walker scale factor in $D$ dimensions and $b$ a Brans-Dicke scalar field in $d$ dimensions respectively. We investigate the $2+D+d$ dimensional cosmological model in some detail.Comment: 23 pages, Late

A non-perturbative study of the action parameters for anisotropic-lattice quarks

A quark action designed for highly anisotropic lattice simulations is discussed. The mass-dependence of the parameters in the action is studied and the results are presented. Applications of this action in studies of heavy quark quantities are described and results are presented from simulations at an anisotropy of six, for a range of quark masses from strange to bottom.Comment: 9 pages, 8 figure

The Carboxyl-Terminal Segment of Apolipoprotein A-V Undergoes a Lipid-Induced Conformational Change

Apolipoprotein (apo) A-V is a 343-residue, multidomain protein that plays an important role in regulation of plasma triglyceride homeostasis. Primary sequence analysis revealed a unique tetraproline sequence (Pro293-Pro296) near the carboxyl terminus of the protein. A peptide corresponding to the 48-residue segment beyond the tetraproline motif was generated from a recombinant apoA-V precursor wherein Pro295 was replaced by Met. Cyanogen bromide cleavage of the precursor protein, followed by negative affinity chromatography, yielded a purified peptide. Nondenaturing polyacrylamide gel electrophoresis verified that apoA-V(296-343) solubilizes phospholipid vesicles, forming a relatively heterogeneous population of reconstituted high-density lipoprotein with Stokes’ diameters\u3e17 nm. At the same time, apoA-V(296-343) failed to bind a spherical lipoprotein substrate in vitro. Far-UV circular dichroism spectroscopy revealed the peptide is unstructured in buffer yet adopts significant R-helical secondary structure in the presence of the lipid mimetic solvent trifluoroethanol (TFE; 50% v/v). Heteronuclear multidemensional NMR spectroscopy experiments were conducted with uniformly 15N- and 15N/13C-labeled peptide in 50% TFE. Peptide backbone assignment and secondary structure prediction using TALOSþ reveal the peptide adopts R-helix secondary structure from residues 309 to 334. In TFE, apoA-V(296-343) adopts an extended amphipathic R-helix, consistent with a role in lipoprotein binding as a component of full-length apoA-V