Differential treatment of bipolar disorder with old and new antiepileptic drugs

Although lithium remains the preferred medication for bipolar disorders, new investigations suggest that only 60 to 80% of patients have a good response with a classical presentation. The antiepileptics carbamazepine and valproate are important alternatives. Several studies have shown that lithium, carbamazepine and valproate are effective in pure mania. Mixed mania and rapid cycling respond, however, well to valproate. One disadvantage of carbamazepine is its enzyme inducing property with the consequence of a decrease of plasma levels of other psychotropic medications and a worsening of psychopathology. First data indicate a good antimanic and antidepressive efficacy of the new antiepileptic drug lamotrigine

Do Buyer-Size Discounts Depend on the Curvature of the Surplus Function? Experimental Tests of Bargaining Models

A number of recent theoretical papers have shown that for buyer-size discounts to emerge in a bargaining model, the total surplus function over which parties bargain must have certain nonlinearities. We test the theory in an experimental setting in which a seller bargains with a number of buyers of different sizes. We generate nonlinearities in the surplus function by varying the shape of the seller's cost function. Our results strongly support the theory. As predicted, large-buyer discounts emerge only in the case of increasing marginal cost, corresponding to a concave surplus function.buyer-size discounts, large buyer, experimental economics.

Fractional-Power-Law Level-Statistics due to Dynamical Tunneling

For systems with a mixed phase space we demonstrate that dynamical tunneling universally leads to a fractional power law of the level-spacing distribution P(s) over a wide range of small spacings s. Going beyond Berry-Robnik statistics, we take into account that dynamical tunneling rates between the regular and the chaotic region vary over many orders of magnitude. This results in a prediction of P(s) which excellently describes the spectral data of the standard map. Moreover, we show that the power-law exponent is proportional to the effective Planck constant h.Comment: 4 pages, 2 figure

Communication in Vertically Related Markets: Experimental Evidence

When an upstream monopolist supplies several competing downstream firms, it may fail to monopolize the market because of opportunistic behavior towards the downstream firms. We analyze this well-known commitment problem in an experiment where we extend previous research by allowing for communication. In one treatment, the upstream firm can bilaterally talk to either of two downstream firms. In a second treatment, all three firms talk together. We find that the treatment with bilateral communication leads to fewer rejections of offers and higher joint profits than a baseline treatment without communication, but output is still above the monopoly benchmark. Only the treatment where all three firms can communicate leads to complete monopolization. Such communication effectively works as a vertical restraint and should be regarding as potentially anticompetitive

Dynamic-ADAPT-QAOA: An algorithm with shallow and noise-resilient circuits

The quantum approximate optimization algorithm (QAOA) is an appealing proposal to solve NP problems on noisy intermediate-scale quantum (NISQ) hardware. Making NISQ implementations of the QAOA resilient to noise requires short ansatz circuits with as few CNOT gates as possible. Here, we present Dynamic-ADAPT-QAOA. Our algorithm significantly reduces the circuit depth and the CNOT count of standard ADAPT-QAOA, a leading proposal for near-term implementations of the QAOA. Throughout our algorithm, the decision to apply CNOT-intensive operations is made dynamically, based on algorithmic benefits. Using density-matrix simulations, we benchmark the noise resilience of ADAPT-QAOA and Dynamic-ADAPT-QAOA. We compute the gate-error probability $p_\text{gate}^\star$ below which these algorithms provide, on average, more accurate solutions than the classical, polynomial-time approximation algorithm by Goemans and Williamson. For small systems with $6-10$ qubits, we show that $p_{\text{gate}}^\star>10^{-3}$ for Dynamic-ADAPT-QAOA. Compared to standard ADAPT-QAOA, this constitutes an order-of-magnitude improvement in noise resilience. This improvement should make Dynamic-ADAPT-QAOA viable for implementations on superconducting NISQ hardware, even in the absence of error mitigation.Comment: 15 pages, 9 figure

Childhood executive function predicts internalizing and externalizing symptoms in emerging adults with and without autism: A 10-year longitudinal study

Individuals with autism spectrum disorder (ASD) and typically developing individuals were assessed on three neuropsychological tests of executive function (EF) and on scales of autism symptoms and co-occurring internalizing and externalizing symptoms at baseline (T1; N = 88, Mage = 11.8 years, 73% males), 2-year (T2; 99% retention, Mage = 13.9 years), and 10-year follow-ups (T3; 75% retention, Mage = 21.4 years). An EF composite score from T1 significantly predicted internalizing symptoms at T2 (β = .228) and internalizing and externalizing symptoms at T3 (β = .431 and .478, respectively), when controlling for age and autism symptoms. OThe findings suggest that EF difficulties are a long-term risk factor for more co-occurring symptoms.Childhood executive function predicts internalizing and externalizing symptoms in emerging adults with and without autism: A 10-year longitudinal studyThis work was supported by grants from the Innlandet Hospital Trust (grant numbers: 150663, 150610, 150624, and 150648) and from the Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias, Department of Rare Disorders and Disabilities, Oslo University Hospital (grant number: 150616)publishedVersio

Communication in Vertical Markets: Experimental Evidence

When an upstream monopolist supplies several competing downstreamfirms, it may fail to monopolize the market because it is unable to commit not to behave opportunistically. We build on previous experimental studies of this well-known commitment problem by introducing communication. Allowing the upstream firm to chat privately with each downstream firm reduces total offered quantity from near the Cournot level (observed in the absence of communication) halfway toward the monopoly level. Allowing all three firms to chat together openly results in complete monopolization. Downstream firms obtain such a bargaining advantage from open communication that all of the gains from monopolizing the market accrue to them. A simple structural model of Nash-in-Nash bargaining fits the pattern of shifting surpluses well. Using third-party coders, unsupervised text mining, among other approaches, we uncover features of the rich chat data that are correlated with market outcomes. We conclude with a discussion of the antitrust implications of open communication in vertical markets

Charting service quality gaps

Some of the most influential models in the service management literature (Parasuraman et al., 1985; Grönroos, 1990) focus on the concept of service quality gap (SQG). Parasuraman et al. (1985) define a pioneering model with five SQGs, the concepts of which are amplified in Brogowicz et al.’s (1990) model. The latter has five types of encompassing gaps: information and feedback-related gaps; design-related gaps; implementation-related gaps; communication-related gaps; and customers’ perceptions and expectations related gaps. Additionally to this model amplification, other authors (e.g., Brown & Swartz, 1989) have pointed to relevant SQGs that have not been considered previously. This paper integrates current models and a group of SQGs dispersed through the literature in a new comprehensive model. It draws a link between the model and the stages of a strategy process, emphasising the SQGs’ impact on the process and raising relevant research questions.FCT, FEUALG, UALG