7 research outputs found
Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer
Get PDFInsulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer
880 Prevalence of PSA recurrence after radical prostatectomy of localised prostate cancer with positive resection margin depends on the pathological stage and on the Gleason score: Long term results of a retrospective, single center study
No full text292 AUTOLOGOUS TRANSPLANTATION OF CULTURED FIBROBLASTS FOR POTENTIAL BULKING AGENT AT THE URETEROVESICAL JUNCTION
No full text803 Immunohistochemical ERG status is not predictive for biochemical recurrence after radical prostatectomy with positive surgical margin
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