Seismic Performance of Anchored Brick Veneer

A study was conducted on the out-of-plane seismic performance of anchored brick veneer with wood-frame backup wall systems, to evaluate prescriptive design requirements and current construction practices. Prescriptive requirements for the design and construction of anchored brick veneer are currently provided by the Masonry Standards Joint Committee (MSJC) Building Code, the International Residential Code (IRC) for Oneand Two-Family Dwellings, and the Brick Industry Association (BIA) Technical Notes. Laboratory tests were conducted on brick-tie-wood subassemblies, comprising two bricks with a corrugated sheet metal tie either nail- or screw-attached to a wood stud, permitting an evaluation of the stiffness, strength, and failure modes for a local portion of a veneer wall system, rather than just of a single tie by itself. Then, full-scale brick veneer wall specimens (two one-story solid walls, as well as a one-and-a-half story wall with a window opening and a gable region) were tested under static and dynamic out-of-plane loading on a shake table. The shake table tests captured the performance of brick veneer wall systems, including interaction and load-sharing between the brick veneer, corrugated sheet metal ties, and wood-frame backup. Finally, all of these test results were used to develop finite element models of brick veneer wall systems, including nonlinear inelastic properties for the tie connections. The experimental and analytical studies showed that the out-of-plane seismic performance of residential anchored brick veneer walls is generally governed by: tensile stiffness and strength properties of the tie connections, as controlled by tie installation details; overall grid spacing of the tie connections, especially for tie installation along the edges and in the upper regions of walls; and, overall wall geometric variations. Damage limit states for single-story residential brick veneer wall systems were established from the experimental and analytical studies as a function of tensile failure of key tie connections, and the seismic fragility of this form of construction was then evaluated. Based on the overall findings, it is recommended that codes incorporate specific requirements for tie connection installation along all brick veneer wall edges, as well as for tie connection installation at reduced spacings in the upper regions of wall panels and near stiffer regions of the backup. Residential anchored brick veneer construction should as a minimum be built in accordance with the current prescriptive code requirements and recommendations, throughout low to moderate seismicity regions of the central and eastern U.S., whereas non-compliant methods of construction commonly substituted in practice are generally not acceptable.published or submitted for publicatio

trieFinder: an efficient program for annotating Digital Gene Expression (DGE) tags

BACKGROUND: Quantification of a transcriptional profile is a useful way to evaluate the activity of a cell at a given point in time. Although RNA-Seq has revolutionized transcriptional profiling, the costs of RNA-Seq are still significantly higher than microarrays, and often the depth of data delivered from RNA-Seq is in excess of what is needed for simple transcript quantification. Digital Gene Expression (DGE) is a cost-effective, sequence-based approach for simple transcript quantification: by sequencing one read per molecule of RNA, this technique can be used to efficiently count transcripts while obviating the need for transcript-length normalization and reducing the total numbers of reads necessary for accurate quantification. Here, we present trieFinder, a program specifically designed to rapidly map, parse, and annotate DGE tags of various lengths against cDNA and/or genomic sequence databases. RESULTS: The trieFinder algorithm maps DGE tags in a two-step process. First, it scans FASTA files of RefSeq, UniGene, and genomic DNA sequences to create a database of all tags that can be derived from a predefined restriction site. Next, it compares the experimental DGE tags to this tag database, taking advantage of the fact that the tags are stored as a prefix tree, or “trie”, which allows for linear-time searches for exact matches. DGE tags with mismatches are analyzed by recursive calls in the data structure. We find that, in terms of alignment speed, the mapping functionality of trieFinder compares favorably with Bowtie. CONCLUSIONS: trieFinder can quickly provide the user an annotation of the DGE tags from three sources simultaneously, simplifying transcript quantification and novel transcript detection, delivering the data in a simple parsed format, obviating the need to post-process the alignment results. trieFinder is available at http://research.nhgri.nih.gov/software/trieFinder/

Current Research Topics: Railroad Bridges and Structural Engineering

Railroad infrastructure must be maintained safely and reliably for both owners and users. Railroad bridge expenditures in particular represent about 10% of the annual capital investment for Class I railroads in the United States (U.S.). Due to the lack of flexibility of railroad networks, railroads cannot afford not to repair or replace bridges that should be either partially upgraded or completely renovated. If they fail to do so, maintenance expenses and/or structural failure could cause railroads to lose money that would have been saved if part of it had been properly budgeted and used in the first place. Beyond these financial concerns associated with railroad bridge management, railroads (which are private commercial enterprises in the U.S.) are widely recognized for placing a high priority on safety. Academia, government, and railroad bridge engineering agencies have, over the years, all formally studied a variety of railroad bridge research topics. In the past, workshops have assisted railroad institutions toward directing research efforts based on the current needs of the railroad bridge structural engineering community. This report is the result of a new survey-based study entitled “Current Research Topics: Railroad Bridges and Structural Engineering.” The lead author of this report planned and conducted the survey during the 2009-2010 academic years, and comprised the results and findings during 2011. Research topics were selected and prioritized following the results of a detailed telephone survey conducted with sixteen experts on railroad bridges and structural engineering in North America. This report includes a literature review that was developed to follow up on topics discussed during the course of the survey interviews. In addition, other focused conversations with key professionals in both the railroad bridges and structural engineering communities (including experts on associated technologies from academia and industry) have been incorporated into this report. The increased nationwide attention toward high-speed railroads has also been addressed. Finally, new federal regulations affecting railroad bridge management in the U.S. have been examined and included. This survey-based study identifies the management of railroad bridges as a primary concern for railroad bridge structural engineers today. Field assessment, especially as it relates to bridge capacity, is of particular interest. The nearterm implementation of Structural Health Monitoring (SHM) into railroad bridge management has been identified as a potential tool for railroad bridge management. Finally, current and future research in this and other related areas is briefly discussed and proposed. In summary, this report identifies current structural engineering research topics of interest for railroad bridges in North America. In particular, the railroad bridge structural engineering community finds the assessment of bridge performance under traffic loading by using emerging SHM techniques to be a top research interest. As a consequence, SHM implementation for railroad bridges management should be given high priority for research and development.Association of American Railroads (AAR) Technology Scanning ProgramMax Zar ScholarshipSEI ASCE O. H. Amman Research FellowshipTalentia Fellowship (Junta de Andalucia, Spain

Genome-wide analysis of transposon and retroviral insertions reveals preferential integrations in regions of DNA flexibility

DNA transposons and retroviruses are important transgenic tools for genome engineering. An important consideration affecting the choice of transgenic vector is their insertion site preferences. Previous large-scale analyses of Ds transposon integration sites in plants were done on the basis of reporter gene expression or germline transmission, making it difficult to discern vertebrate integration preferences. Here, we compare over 1300 Ds transposon integration sites in zebrafish, with Tol2 transposon and retroviral integration sites. Genome-wide analysis shows that Ds integration sites in the presence or absence of marker selection are remarkably similar and distributed throughout the genome. No strict motif was found, but a preference for structural features in the target DNA associated with DNA flexibility (Twist, Tilt, Rise, Roll, Shift and Slide) was observed. Remarkably, this feature is also found in transposon and retroviral integrations in maize and mouse cells. Our findings show that structural features influence integration of heterologous DNA in genomes, and have implications for targeted genome engineering

Seismic Performance of Integral Abutment Highway Bridges in Illinois

The seismic behavior of integral abutment bridges (IABs) is of particular interest in southern Illinois, where proximity to the New Madrid Seismic Zone may create significant ground motion accelerations during an earthquake. IABs are common in modern bridge construction due to their lack of expansion joints between the superstructure and abutment, which leads to decreased environmental damage at the abutment seat when compared to stub abutment bridges. However, elimination of expansion joints can also lead to development of complex soil-structure-interaction limit states at the abutment and its foundation when an IAB is subjected to lateral loads. This report examines the seismic behavior of typical IABs in southern Illinois and develops feedback and recommendations for improving IAB seismic designs. This is accomplished through modeling IABs as a whole bridge system, subjecting the models to representative ground motions, monitoring the behavior of key IAB components, using the monitored results to form a comprehensive view of seismic behavior, and employing the developed knowledge to form recommendations for improving IAB seismic performance. IAB models are developed in OpenSees through nonlinear modeling of multiple components, as well as the connections between components, representing typical IAB designs for Illinois, and are then subjected to 1000-year return period hazard ground motions developed specifically for southern Illinois. Incremental dynamic analyses are also performed. IABs of varying superstructure materials, span configurations, bearing layouts, pier heights, and foundation soil conditions are dynamically analyzed using the sets of developed ground motions. Damage to pier columns is especially prominent in IABs with shorter piers and longer abutment-to-abutment spans, while abutment foundation damage in terms of yielding, local buckling, and rupture of the piles frequently occurs in many IAB variants. Recommendations on design modifications to improve the seismic behavior of IABs by limiting the level of damage to these components are also investigated through modifying elastomeric bearing side retainer strength, fixed bearing strength, pier column size, and backfill contributions.IDOT-R27-133Ope

Effect of increased tensile strength and toughness on reinforcing-bar bond behavior

The research reported here investigated the pull-out behavior of deformed reinforcing bars embedded in fiber-reinforced-concrete (FRC) and high-performance- fiber-reinforced-concrete (HPFRC) matrices exhibiting increased tensile strength and toughness. Increased strength and toughness of the embedding matrix resulted in a significant increase in pull-out strength, strain capacity, and over-all ductility, as well as more stable crack development. Additionally, when sufficient lateral constraint (i.e. cover thickness) was provided, the use of an HPFRC matrix exhibiting strain-hardening behavior resulted in a slip-hardening pull-out response.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31895/1/0000848.pd

Seismic Performance of Seat-Type Abutment Highway Bridges in Illinois

This study assesses the seismic performance of quasi-isolated highway bridges with seat-type abutments, validates the current IDOT design strategy, and provides recommendations for improving a bridge’s seismic behavior. To encompass common configurations of highway bridges with non-seismically designed bearing components employed as sacrificial connections between superstructures and substructures, a suite of prototype bridges with variations in span arrangement, girder type, skew angle, pier column height, and foundation soil condition were studied. Detailed three-dimensional nonlinear finite-element models were developed for the bridges, incorporating various critical structural components and geotechnical mechanisms. Multi-mode adaptive pushover analyses were conducted to investigate bridge response characteristics in terms of the force distribution among substructures, the sequence of limit state occurrences, the fusing of sacrificial connections, and the vulnerability of critical bridge components. Eigenvalue modal analyses were also performed in the elastic and inelastic deformation states to reveal modal response characteristics of the bridges. The study culminated in an extensive seismic performance assessment of quasi-isolated bridges, for which thousands of nonlinear dynamic time-history analyses were carried out. The bridges were subjected to a suite of site-specific earthquake ground motions, taking into account the site condition and the regional seismicity of Cairo, Illinois. Assessment results validated that the current quasi-isolation bridge design strategy is generally effective, and the majority of the studied prototype bridges are unlikely to fail in global collapse when subjected to horizontal earthquake ground motions with a 1,000-year return period in deep southern Illinois. Although most of the prototype bridges exhibited satisfactory seismic performance, the response of a small number of them demonstrated a risk of bearing unseating and severe pier column damage. With the aim of improving the seismic performance of these bridges, preliminary recommendations for calibrating the current design strategy were proposed, and their efficacy was demonstrated by comparative studies.IDOT-R27-133Ope

Modification of ground motions for use in Central North America: Southern Illinois surface ground motions for structural analysis

The lack of ground motion time history records with a 1000-year return period hazard for Central North America (CNA) often requires earthquake engineering researchers in the area to develop ground motions of their own. This report briefly describes a procedure for developing 1000-year return period ground motion time history records, and this procedure was applied for 10 sites in southern Illinois. Accompanying this report are 20 individual ground motion time history records developed at each of the 10 sites (for a total of 200 ground motions). These ground motions may be useful for various purposes including in dynamic structural analyses of bridges and other structures in southern Illinois (and potentially other CNA regions). The accompanying ground motions are developed following the detailed procedure presented in Kozak et al. [2017]. See "Has Parts" for persistent link to ground motion data files.Ope

Homeomorphic Embedding for Online Termination of Symbolic Methods

Well-quasi orders in general, and homeomorphic embedding in particular, have gained popularity to ensure the termination of techniques for program analysis, specialisation, transformation, and verification. In this paper we survey and discuss this use of homeomorphic embedding and clarify the advantages of such an approach over one using well-founded orders. We also discuss various extensions of the homeomorphic embedding relation. We conclude with a study of homeomorphic embedding in the context of metaprogramming, presenting some new (positive and negative) results and open problems