Towards an Understanding of the Globular Cluster Over--abundance around the Central Giant Elliptical NGC 1399

We investigate the kinematics of a combined sample of 74 globular clusters around NGC 1399. Their high velocity dispersion, increasing with radius, supports their association with the gravitational potential of the galaxy cluster rather than with that of NGC 1399 itself. We find no evidence for rotation in the full sample, although some indication for rotation in the outer regions. The data do not allow us to detect differences between the kinematics of the blue and red sub-populations of globular clusters. A comparison between the globular cluster systems of NGC 1399 and those of NGC 1404 and NGC 1380 indicates that the globular clusters in all three galaxies are likely to have formed via similar mechanisms and at similar epochs. The only property which distinguishes the NGC 1399 globular cluster system from these others is that it is ten times more abundant. We summarize the evidence for associating these excess globulars with the galaxy cluster rather than with NGC 1399 itself, and suggest that the over-abundance can be explained by tidal stripping, at an early epoch, of neighboring galaxies and subsequent accumulation of globulars in the gravitational potential of the galaxy cluster.Comment: AJ accepted (March issue), 27 pages (6 figures included), AAS style, two columns. Also available at http://www.eso.org/~mkissle

The Ionized Gas Kinematics of the LMC-Type Galaxy NGC 1427A in the Fornax Cluster

NGC 1427A is a LMC-like irregular galaxy in the Fornax cluster with an extended pattern of strong star formation around one of its edges, which is probably due to some kind of interaction with the cluster environment. We present H-alpha velocities within NGC 1427A, obtained through long-slit spectroscopy at seven different positions, chosen to fall on the brightest HII regions of the galaxy. Due to its location very near the center of the cluster this object is an excellent candidate to study the effects that the cluster environment has on gas-rich galaxies embedded in it. The rotation of NGC 1427A is modeled in two different ways. The global ionized gas kinematics is reasonably well described by solid-body rotation, although on small scales it shows a chaotic behaviour. In this simple model, the collision with a smaller member of the cluster as being responsible for the peculiar morphology of NGC 1427A is very unlikely, since the only candidate intruder falls smoothly into the general velocity pattern of the main galaxy. In a more elaborate model, for which we obtain a better solution, this object does not lie in the same plane of NGC 1427A, in which case we identify it as a satellite bound to the galaxy. These results are discussed in the context of a normal irregular versus one interacting with some external agent. Based on several arguments and quantitative estimates, we argue that the passage through the hot intracluster gas of the Fornax cluster is a very likely scenario to explain the morphological properties of NGC 1427A.Comment: 31 pages, LaTeX2e, uses aas2pp4.sty and psfig.sty, including 7 Postscript figures; accepted for publication in ApJ, Vol. 530, February 200

Intent to use a web-based psychological intervention for partners of cancer patients:Associated factors and preferences

This study examined partners of cancer patients intention to use a web-based psychological intervention, their preferences regarding its preconditions, functionalities and topics, and factors related to their intention. One hundred and sixty-eight partners completed a questionnaire about these aspects. Forty-eight percent of the partners would (maybe) make use of a web-based intervention. Partners who intended to participate were significantly younger, used the Internet more often, and perceived more caregiver strain. Most partners preferred an intervention that takes less than 1 hour/week, lasts five weeks or more, and contains information and peer support. Half of the partners would like to receive online guidance

Web-based self-help intervention for partners of cancer patients based on acceptance and commitment therapy and self-compassion training:a randomized controlled trial with automated versus personal feedback

Purpose: To evaluate the effectiveness of two versions (personal or automated feedback) of a psychological Web-based self-help intervention targeting partners of cancer patients. The intervention was based on acceptance and commitment therapy (ACT) and self-compassion training. Participants’ adherence and their satisfaction were also studied. Methods: Two hundred three partners of patients with heterogeneous entities of cancer were randomized into three conditions: personal feedback (PF) (n = 67), automated feedback (AF) (n = 70), or waiting list (WL) control (n = 66). Participants completed measures at baseline (T0) and post-intervention (T1; 3 months after baseline) to assess psychological distress (HADS; primary outcome), positive mental health, caregiver strain, general health (secondary outcomes), posttraumatic growth, resilience, self-compassion, psychological flexibility, sense of mastery, and relational communication style (process measures). Participants in the two experimental conditions also completed these measures at follow-up (T2; 6 months after baseline). Results: There was no significant difference in change in psychological distress, positive mental health, caregiver strain and general health from T0 to T1 for either of the experimental conditions compared with the WL-condition. However, when compared to a WL-condition, the PF-condition was effective in increasing psychological flexibility (effect size d = 0.49) and resilience (d = 0.12) and decreasing overprotection (d = 0.25), and the AF-condition was effective in reducing overprotection (d = 0.36) and improving protective buffering (d = 0.36). At follow-up, the PF-condition was more effective than the AF-condition for improving mental health (d = 0.36), psychological flexibility (d = 0.60), mastery (d = 0.48), and protective buffering (d = 0.24). Participants positively appreciated the intervention and 69% participants were adherent. Conclusion: This study demonstrates that a Web-based intervention based on ACT and self-compassion training with automated or personal feedback does not seem to improve psychological distress; however, it may have the potential to support partners of cancer patients to cope with the difficult situation they are facing. The condition with personal feedback seemed to be more beneficial

The Efficiency of Globular Cluster Formation

(Abridged): The total populations of globular cluster systems (GCSs) are discussed in terms of their connection to the efficiency of globular cluster formation---the mass fraction of star-forming gas that was able to form bound stellar clusters rather than isolated stars or unbound associations---in galaxy halos. Observed variations in GCS specific frequencies (S_N=N_gc/L_gal), both as a function of galactocentric radius in individual systems and globally between entire galaxies, are reviewed in this light. It is argued that trends in S_N do not reflect any real variation in the underlying efficiency of cluster formation; rather, they result from ignoring the hot gas in many large ellipticals. This claim is checked and confirmed in each of M87, M49, and NGC 1399, for which existing data are combined to show that the volume density profile of globular clusters, rho_cl, is directly proportional to the sum of (rho_gas+rho_stars) at large radii. The constant of proportionality is the same in each case: epsilon=0.0026 +/- 0.0005 in the mean. This is identified with the globular cluster formation efficiency. The implication that epsilon might have had a universal value is supported by data on the GCSs of 97 early-type galaxies, on the GCS of the Milky Way, and on the ongoing formation of open clusters. These results have specific implications for some issues in GCS and galaxy formation, and they should serve as a strong constraint on more general theories of star and cluster formation.Comment: 36 pages with 11 figures; accepted for publication in The Astronomical Journa

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

Garlic extracts have been shown to decrease drug exposure for saquinavir, a P-glycoprotein and cytochrome P450 3A4 substrate. In order to explore the underlying mechanisms and to study the effects of garlic on pre-systemic drug elimination, healthy volunteers were administered garlic extract for 21 days. Prior to and at the end of this period, expression of duodenal P-glycoprotein and cytochrome P450 3A4 protein were assayed and normalized to villin, while hepatic cytochrome P450 3A4 function and simvastatin, pravastatin and saquinavir pharmacokinetics were also evaluated. Ingestion of garlic extract increased expression of duodenal P-glycoprotein to 131% (95% CI, 105-163%), without increasing the expression of cytochrome P450 3A4 which amounted to 87% (95% CI, 67-112%), relative to baseline in both cases. For the erythromycin breath test performed, the average result was 96% (95% CI, 83-112%). Ingestion of garlic extract had no effect on drug and metabolite AUCs following a single dose of simvastatin or pravastatin, although the average area under the plasma concentration curve (AUC) of saquinavir decreased to 85% (95% CI, 66-109%), and changes in intestinal P-glycoprotein expression negatively correlated with this change. In conclusion, garlic extract induces intestinal expression of P-glycoprotein independent of cytochrome P450 3A4 in human intestine and liver

Carbon Nanotube Solar Cells

We present proof-of-concept all-carbon solar cells. They are made of a photoactive side of predominantly semiconducting nanotubes for photoconversion and a counter electrode made of a natural mixture of carbon nanotubes or graphite, connected by a liquid electrolyte through a redox reaction. The cells do not require rare source materials such as In or Pt, nor high-grade semiconductor processing equipment, do not rely on dye for photoconversion and therefore do not bleach, and are easy to fabricate using a spray-paint technique. We observe that cells with a lower concentration of carbon nanotubes on the active semiconducting electrode perform better than cells with a higher concentration of nanotubes. This effect is contrary to the expectation that a larger number of nanotubes would lead to more photoconversion and therefore more power generation. We attribute this to the presence of metallic nanotubes that provide a short for photo-excited electrons, bypassing the load. We demonstrate optimization strategies that improve cell efficiency by orders of magnitude. Once it is possible to make semiconducting-only carbon nanotube films, that may provide the greatest efficiency improvement

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

<p>Abstract</p> <p>Background</p> <p>Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell-based assays for the prediction of sensitization. The aim is to replace animal experiments with in vitro tests displaying a higher predictive power.</p> <p>Results</p> <p>We have developed a novel cell-based assay for the prediction of sensitizing chemicals. By analyzing the transcriptome of the human cell line MUTZ-3 after 24 h stimulation, using 20 different sensitizing chemicals, 20 non-sensitizing chemicals and vehicle controls, we have identified a biomarker signature of 200 genes with potent discriminatory ability. Using a Support Vector Machine for supervised classification, the prediction performance of the assay revealed an area under the ROC curve of 0.98. In addition, categorizing the chemicals according to the LLNA assay, this gene signature could also predict sensitizing potency. The identified markers are involved in biological pathways with immunological relevant functions, which can shed light on the process of human sensitization.</p> <p>Conclusions</p> <p>A gene signature predicting sensitization, using a human cell line in vitro, has been identified. This simple and robust cell-based assay has the potential to completely replace or drastically reduce the utilization of test systems based on experimental animals. Being based on human biology, the assay is proposed to be more accurate for predicting sensitization in humans, than the traditional animal-based tests.</p