Phase Mixing of Nonlinear Plasma Oscillations in an Arbitrary Mass Ratio Cold Plasma

Nonlinear plasma oscillations in an arbitrary mass ratio cold plasma have been studied using 1-D particle-in-cell simulation. In contrast to earlier work for infinitely massive ion plasmas it has been found that the oscillations phase mix away at any amplitude and that the rate at which phase mixing occurs, depends on the mass ratio ($\Delta = m_{-}/m_{+}$) and the amplitude. A perturbation theoretic calculation carried upto third order predicts that the normalized phase mixing time $\omega_{p-} t_{mix}$ depends on the amplitude $A$ and the mass ratio $\Delta$ as $\sim [(A^{2}/24)(\Delta/\sqrt{1 + \Delta})]^{-1/3}$. We have confirmed this scaling in our simulations and conclude that stable non-linear oscillations which never phase mix, exist only for the ideal case with $\Delta = 0.0$ and $A < 0.5$. These cold plasma results may have direct relevance to recent experiments on superintense laser beam plasma interactions with applications to particle acceleration, fast ignitor concept etc.Comment: pp 10 and two figures in PS forma

Translational independence between overlapping genes for a restriction endonuclease and its transcriptional regulator

<p>Abstract</p> <p>Background</p> <p>Most type II restriction-modification (RM) systems have two independent enzymes that act on the same DNA sequence: a modification methyltransferase that protects target sites, and a restriction endonuclease that cleaves unmethylated target sites. When RM genes enter a new cell, methylation must occur before restriction activity appears, or the host's chromosome is digested. Transcriptional mechanisms that delay endonuclease expression have been identified in some RM systems. A substantial subset of those systems is controlled by a family of small transcription activators called C proteins. In the PvuII system, C.PvuII activates transcription of its own gene, along with that of the downstream endonuclease gene. This regulation results in very low R.PvuII mRNA levels early after gene entry, followed by rapid increase due to positive feedback. However, given the lethal consequences of premature REase accumulation, transcriptional control alone might be insufficient. In C-controlled RM systems, there is a ± 20 nt overlap between the C termination codon and the R (endonuclease) initiation codon, suggesting possible translational coupling, and in many cases predicted RNA hairpins could occlude the ribosome binding site for the endonuclease gene.</p> <p>Results</p> <p>Expression levels of <it>lacZ </it>translational fusions to <it>pvuIIR </it>or <it>pvuIIC </it>were determined, with the native <it>pvuII </it>promoter having been replaced by one not controlled by C.PvuII. In-frame <it>pvuIIC </it>insertions did not substantially decrease either <it>pvuIIC-lacZ </it>or <it>pvuIIR-lacZ </it>expression (with or without C.PvuII provided <it>in trans</it>). In contrast, a frameshift mutation in <it>pvuIIC </it>decreased expression markedly in both fusions, but mRNA measurements indicated that this decrease could be explained by transcriptional polarity. Expression of <it>pvuIIR-lacZ </it>was unaffected when the <it>pvuIIC </it>stop codon was moved 21 nt downstream from its WT location, or 25 or 40 bp upstream of the <it>pvuIIR </it>initiation codon. Disrupting the putative hairpins had no significant effects.</p> <p>Conclusions</p> <p>The initiation of translation of <it>pvuIIR </it>appears to be independent of that for <it>pvuIIC</it>. Direct tests failed to detect regulatory rules for either gene overlap or the putative hairpins. Thus, at least during balanced growth, transcriptional control appears to be sufficiently robust for proper regulation of this RM system.</p

Fully nonlinear excitations of non-Abelian plasma

We investigate fully nonlinear, non-Abelian excitations of quark-antiquark plasma, using relativistic fluid theory in cold plasma approximation. There are mainly three important nonlinearities, coming from various sources such as non-Abelian interactions of Yang-Mills (YM) fields, Wong's color dynamics and plasma nonlinearity, in our model. By neglecting nonlinearities due to plasma and color dynamics we get back the earlier results of Blaizot {\it et. al.}, Phys. Rev. Lett. 72, 3317 (1994). Similarly, by neglecting YM fields nonlinearity and plasma nonlinearity, it reduces to the model of Gupta {\it et. al.}, Phys. Lett. B498, 223 (2005). Thus we have the most general non-Abelian mode of quark-gluon plasma (QGP). Further, our model resembles the problem of propagation of laser beam through relativistic plasma, Physica 9D, 96 (1983). in the absence of all non-Abelian interactions.Comment: 8 pages, 2 figures, articl

Medical interventions for non‐arteritic anterior ischaemic optic neuropathy

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety of different medical interventions in the treatment of non‐arteritic anterior ischaemic optic neuropathy (NA‐AION) in adults

Effect of sheared flows on classical and neoclassical tearing modes

The influence of toroidal sheared equilibrium flows on the nonlinear evolution of classical and neoclassical tearing modes is studied through numerical solutions of a set of reduced generalized MHD equations that include viscous force effects based on neoclassical closures. In general, differential flow is found to have a strong stabilizing influence leading to lower saturated island widths for the classical tearing mode and reduced growth rates for the neoclassical mode. Velocity shear, on the other hand, is seen to make a destabilizing contribution

Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation

BACKGROUND: Vascular smooth muscle cells (SMCs) undergo complex phenotypic modulation with atherosclerotic plaque formation in hyperlipidemic mice, which is characterized by de-differentiation and heterogeneous increases in the expression of macrophage, fibroblast, osteogenic, and stem cell markers. An increase of cellular cholesterol in SMCs triggers similar phenotypic changes in vitro with exposure to free cholesterol due to cholesterol entering the endoplasmic reticulum, triggering endoplasmic reticulum stress and activating Perk (protein kinase RNA-like endoplasmic reticulum kinase) signaling. METHODS: We generated an SMC-specific RESULTS: SMC-specific deletion of Perk reduces atherosclerotic plaque formation in male hyperlipidemic mice by 80%. Single-cell transcriptomic data identify 2 clusters of modulated SMCs in hyperlipidemic mice, one of which is absent when CONCLUSIONS: Our results indicate that hypercholesterolemia drives both Perk-dependent and Perk-independent SMC modulation and that deficiency of Perk significantly blocks atherosclerotic plaque formation

Gamma ray flashes by plasma effects in the middle atmosphere

In this paper a novel mechanism is identified for the generation of gamma ray flashes observed on the Compton Gamma Ray Observatory satellite. During typical cloud to ground lightning flashes, the electromagnetic pulse can create a self-focused whistler wave channel or duct to guide 10-10/cm of ~1 MeV electrons (formed by static stratified electric field in clouds at 20 km), to a height of about 30 km where these electrons can create the gamma ray flash by bremsstrahlung. This scenario combines the various observational features of lightning-generated electromagnetic pulses and low altitude energetic electrons to provide a viable nonlinear transport mechanism of energetic electrons to the desired altitude of 30 km for conversion into gamma ray flashes

Electromagnetic energy penetration in the self-induced transparency regime of relativistic laser-plasma interactions

Two scenarios for the penetration of relativistically intense laser radiation into an overdense plasma, accessible by self-induced transparency, are presented. For supercritical densities less than 1.5 times the critical one, penetration of laser energy occurs by soliton-like structures moving into the plasma. At higher background densities laser light penetrates over a finite length only, that increases with the incident intensity. In this regime plasma-field structures represent alternating electron layers separated by about half a wavelength by depleted regions.Comment: 9 pages, 4 figures, submitted for publication to PR