Separate Submission of Standard Lymphadenectomy in 6 Packets Versus En Bloc Lymphadenectomy in Bladder Cancer

Introduction:Our aim was to evaluate detection of nodal metastasis during radical cystectomy with standard pelvic lymph node dissection versus en bloc lymphadenectomy for the treatment of bladder cancer. Materials And Methods: Hospital records of a total of 77 Patients with radical cystectomy and either standard pelvic lymph node dissection or en bloc lymphadenectomy were reviewed. Nodal dissection specimens during standard lymphadenectomy were sent for pathology examination in 6 separate containers marked as external iliac, internal iliac, and obturator groups from both sides. En bloc dissection specimens were sent in 2 containers marked as the right and the left pelvic nodes. Clinical and pathological findings of these two groups were compared in terms of the number of dissected lymph nodes, number of nodes with metastasis, lymph node density, and clinical outcomes. Results: There were 34 Patients with standard lymph node dissection and 43 with en bloc lymphadenectomy (anterior pelvic exenteration). Age, sex, duration of the disease, number of transurethral resections prior to cystectomy, pathological grade at cystectomy, and stage of the primary tumor were comparable in the two groups of Patients. The median numbers of nodes removed per Patient were 15.5 (range, 4 to 48) and 7.0 (range, 1 to 24) in those with standard and en bloc lymphadenectomy, respectively (P \u3c .001). Nodal involvement was detected in 10 (29.4%) and 9 (20.9%) Patients, respectively (P = .43). Conclusions: Although nodal involvement was not significantly different between the two groups, standard lymphadenectomy submitted in 6 different containers significantly improved the nodal yield over en bloc resection. Obturator nodes were the most commonly involved nodes in our study

Patient\u27s outcome of bladder cancer managed by radical cystectomy with lymphadenectomy at a university hospital

Objective: To study the impact of tumour staging and nodal metastases in predicting 5- year\u27s survival after radical cystectomy and bilateral pelvic lymphadenectomy for primary bladder cancer. Methods: During the period 1995 to 2005, 58 patients underwent radical cystectomy and bilateral pelvic lymphadenectomy and urinary diversion at a University hospital. Patients were identified using medical indexing coding system (ICD 9CM) using standard key words. The patient records were analyzed and follow up data updated. Disease specific survival, death or recurrence was taken as end point.Results: Out of 58 patients, 50 (86%) were males and 8 (14%) females with a mean age of 61 +/- 13.1 years (range from 27 to 87 years). Of 58 patients, 11 (23%) were excluded from the study because of in adequate follow up. The mean follow up was 5.7 years (range, 7 months to 11 years). The overall 5 years survival was 55% with disease specific survival being 66%. Patients with pathological stage TO at cystectomy have 87% 5 years disease specific survival compared to 60%, in patients with pT4 (p = 0.705). The 5-year survival for node positive patients was 16%, compared to 60% for node negative patients (p \u3c 0.01). Conclusions: Radical cystectomy and bilateral pelvic lymphadenectomy is the standard treatment for muscle invasive and high grade T1 cancers, and as salvage for recurrent cancers. Lymphadenectomy has a potential therapeutic benefit. The pathological stage at cystectomy and nodal status are predictors of 5 years survival

Adsorption of Chromium (VI) from Wastewater by Anion Exchange Resin

Strong anion exchange resin (Spectra/Gel IE 1x8) has been investigated as adsorbent for the efficient removal of Cr(VI) ions from synthetic wastewater solutions. Batch experiments were conducted with initial Cr(VI) ions concentration ranging from 25-300 mg/L. Different parameters influencing Cr(VI) adsorption process such as; solution pH, Cr(VI) and adsorbent concentration and contact time were investigated. Results obtained revealed that Cr(VI) was successfully retained by the resin. Equilibrium was established within 30 minutes for initial Cr(VI) concentration up to100 mg/L. The equilibrium data for adsorption of Cr(VI) was fitted with both Langmuir and Freundlich isotherms, however, Langmuir isotherm model was found to be more suitable for the Cr(VI) adsorption and maximum adsorption capacity of the Cr(VI) was found to be 173.8 mg/g. The adsorption process followed second order kinetics. The resin was regenerated by using 4M NaOH as an eluent and retained Cr(VI) adsorption efficiency higher than 83% after three regeneration cycles

Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide were prepared by hot melt method using pure and blended mixture of glyceryl monostearate and stearic acid in different drug to polymer and polymer to polymer ratios. In vitro release characteristics of gliclazide from these hydrophobic matrices were studied over 8 h in phosphate buffer media of pH 7.4. The release kinetics of drug was evaluated for zero order, first order, Higuchi and Peppas kinetic models. It was observed that the release of drug from the matrix was greatly retarded by GMS and retarding effect increased with increasing polymer to drug ratios. On the other hand SA appeared to channel the drug from the wax matrix and release was greatly increased with increasing polymer to drug ratios. The kinetic evaluation of release profile indicated that the Higuchi model was the most appropriate model for describing the release profile of gliclazide. The application of Peppas biexponential equation indicated that non-Fickian release was the predominant mechanism of drug release. The FTIR results showed no interaction between the drug and the polymers and DSC results indicated that both the drug and polymers are in amorphous state and no significant complexes were formed. The results indicated that proper selection of drug to polymer and polymer to polymer ratios were important in order to achieve the desired dissolution profile in these matrix tablets.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Tribological improvement using ionic liquids as additives in synthetic and bio-based lubricants for steel-steel contacts

This study investigates the performance of three ionic liquids (ILs), trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethylpentyl)phosphinate, trihexyl(tetradecyl)phosphonium decanoate, and 1-butyl-3-methylimidazolium tetrafluoroborate, as lubricant additives in synthetic oil polyalphaolefin (PAO8) and bio-based oil trimethylolpropane trioleate (TMPTO). The ILs were added at 0.5, 1.0, and 1.5 wt% concentrations and evaluated in terms of their miscibility with base oils as well as friction- and wear-reducing abilities. Four-ball and high-frequency reciprocating rig (HFRR) tribotesters were employed to evaluate the tribological performance under a boundary lubrication regime. Worn steel surfaces were characterized using optical microscopy, profilometry, scanning electron microscopy (SEM), and energy-dispersive X-ray (EDX) analysis. The results suggested that the addition of trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethylpentyl)phosphinate and trihexyl(tetradecyl)phosphonium decanoate improved the tribological performance of both PAO8 and TMPTO at an optimum concentration of 1 wt%. They showed good friction reduction, lower overall surface wear, and improved surface finishing. 1-Butyl-3-methylimidazolium tetrafluoroborate managed to improve the tribological performance of both base oils only at 0.5 wt%. A further increase in 1-butyl-3-methylimidazolium tetrafluoroborate concentration caused detrimental effects on the steel surface due to the formation of halogenic compounds

Some fixed and periodic point results for generalized contractions on partial ordered metric space with applications in metric space

In this paper, we introduce new type of Θ-contraction in termof a self-mapping on a metric space to obtain common fixed point results. Some examples arealso provided to support the validity of our results and concepts presented herein.As an application of our results, periodic point results forthese Θ-contractions inmetric spaces are proved.Scopu

Effect Of Bio-Based Lubricant Towards Emissions And Engine Breakdown Due To Spark Plug Fouling In A Two-Stroke Engine

Two-stroke also known as two-cycle gasoline engine is a spark ignition engine. Its uniqueness to the four-stroke engine is that this engine does not require lubricant sump, which makes construction lightweight and simple. Its lubricant is mixed with gasoline and burnt together during combustion. There are reports which stated that higher spark plug fouling is due to carbon deposition on the spark plug electrodes on a two-stroke engine when compared to the four-stroke. While many factors could have affected this situation, however, in this paper, the effect of mineral and bio-based lubricants towards carbon deposition and emissions are studied and reported. Idle, half and full throttle operation modes had been conducted on a two-stroke, 43 cubic centimeter engine. To keep combustion temperature below self-cleaning temperature on all three modes of operation, a zero-load test was utilized. This situation accelerates the deposition process as low temperature causes incomplete combustion. This could lead to the accumulation of char, unburned fuel, as well as condensed water and acids as the byproducts blanket the spark plug electrodes and the exhaust system. Five samples had been prepared with a commercially available mineral lubricant (T0) as reference. Trimethylolpropane Trioleate, TMPTO derived from plant origin was used as the bio-based candidate. It was then mixed with T0 which created another four lubricant samples namely T10, T15, T20 and T50 with 10%, 15%, 20% and 50% TMPTO accordingly. Results show that mineral lubricant T0 delivers the lowest hydrocarbon HC, carbon monoxide CO and smoke opacity during idle and half throttle operations. However, it exhibits a greasy deposit on the spark plug circumference and dry carbon deposits on its insulator tip. T0 also emits a liquid residue at the exhaust manifold. T10 and T50 show a wet deposit blanketing both electrodes. Severe deposition was recorded by T50 that caused the engine to fail half way with its emissions had the worst recording. T15 and T20 exhibit only dry carbon deposition on the spark plug circumference. However, T20 has outperformed T15 in terms of emissions with lower CO and CO2 emissions during idling and half-throttling. With better emissions than T15 and better carbon deposition than mineral (T0), T20 could be proposed to be used as a commercial two-stroke lubricant

(4R,5R,6S,7R,8S,9R,10S,13S)-7,8β-Epoxy­momilactone-A

The title compound, C20H26O4, was extracted from Leucas Urticifolia, a wild Lamiaceae herb distributed in the Punjab, Baluchistan, Sindh and the Rajputana desert of Pakistan. The plant is utilized for various medicinal applications by the local community. The title compound is based on the pimarane–diterpene skeleton. The mol­ecule exhibits an ep­oxy ring fused to momilactone-A, leading to a penta­cyclic mol­ecular structure. The absolute configuration was assigned by comparison with the crystal structure of momilactone, but needs further verification. The crystal structure is governed by four inter­molecular hydrogen-bond inter­actions of the C—H⋯O type

Experimental investigation of tribological properties of laser textured tungsten doped diamond like carbon coating under dry sliding conditions at various loads

Laser micro texturing technique has shown its potential in reducing friction and wear at various mechanical interfaces such as automotive and cutting tools etc. Automotive parts are coated with Diamond-like Carbon (DLC) coatings to enhance their performance. Due to stringent condition at the automotive contacts and demand for performance enhancement, increase in performance of DLC coatings is required. In this study laser micro texturing is being combined with tungsten doped DLC coating. In order to analyze the benefits of laser micro texturing on tungsten doped DLC coating. Tribological testing was conducted on a reciprocating test rig at various loading conditions. The results indicated that laser textured tungsten doped DLC coating showed the lower coefficient of friction compared to un-textured tungsten doped DLC coating at a load of 15 N, 25 N and 35 N. Higher graphitization was observed in the case of un-textured coating at 35 N load

Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide were prepared by hot melt method using pure and blended mixture of glyceryl monostearate and stearic acid in different drug to polymer and polymer to polymer ratios. In vitro release characteristics of gliclazide from these hydrophobic matrices were studied over 8 h in phosphate buffer media of pH 7.4. The release kinetics of drug was evaluated for zero order, first order, Higuchi and Peppas kinetic models. It was observed that the release of drug from the matrix was greatly retarded by GMS and retarding effect increased with increasing polymer to drug ratios. On the other hand SA appeared to channel the drug from the wax matrix and release was greatly increased with increasing polymer to drug ratios. The kinetic evaluation of release profile indicated that the Higuchi model was the most appropriate model for describing the release profile of gliclazide. The application of Peppas biexponential equation indicated that non-Fickian release was the predominant mechanism of drug release. The FTIR results showed no interaction between the drug and the polymers and DSC results indicated that both the drug and polymers are in amorphous state and no significant complexes were formed. The results indicated that proper selection of drug to polymer and polymer to polymer ratios were important in order to achieve the desired dissolution profile in these matrix tablets.Colegio de Farmacéuticos de la Provincia de Buenos Aire