Condensation Transition in Polydisperse Hard Rods

We study a mass transport model, where spherical particles diffusing on a ring can stochastically exchange volume $v$, with the constraint of a fixed total volume $V=\sum_{i=1}^N v_i$, $N$ being the total number of particles. The particles, referred to as $p$-spheres, have a linear size that behaves as $v_i^{1/p}$ and our model thus represents a gas of polydisperse hard rods with variable diameters $v_i^{1/p}$. We show that our model admits a factorized steady state distribution which provides the size distribution that minimizes the free energy of a polydisperse hard rod system, under the constraints of fixed $N$ and $V$. Complementary approaches (explicit construction of the steady state distribution on the one hand ; density functional theory on the other hand) completely and consistently specify the behaviour of the system. A real space condensation transition is shown to take place for $p>1$: beyond a critical density a macroscopic aggregate is formed and coexists with a critical fluid phase. Our work establishes the bridge between stochastic mass transport approaches and the optimal polydispersity of hard sphere fluids studied in previous articles

Spacetime Supersymmetry in a nontrivial NS-NS Superstring Background

In this paper we consider superstring propagation in a nontrivial NS-NS background. We deform the world sheet stress tensor and supercurrent with an infinitesimal B_{\mu\nu} field. We construct the gauge-covariant super-Poincare generators in this background and show that the B_{\mu\nu} field spontaneously breaks spacetime supersymmetry. We find that the gauge-covariant spacetime momenta cease to commute with each other and with the spacetime supercharges. We construct a set of "magnetic" super-Poincare generators that are conserved for constant field strength H_{\mu\nu\lambda}, and show that these generators obey a "magnetic" extension of the ordinary supersymmetry algebra.Comment: 13 pages, Latex. Published versio

Making a national atlas of population by computer

This paper describes the conceptual and practical problems encountered and solved in producing a multi-colour atlas of population characteristics in Great Britain. The atlas itself is in A4 format; it consists of some thirty-four maps of Great Britain in four colours and the same number of regional maps, together with descriptive text. All maps were plotted on a laser plotter with a resolution of 127 microns. The paper describes how mapping of ratios, such as percentages, was found to be highly misleading and describes the novel probability mapping solution adopted, based on the signed chi-square statistic. In addition, the rationale for selecting the class intervals and for selecting colour schemes is described

Complexation of DNA with positive spheres: phase diagram of charge inversion and reentrant condensation

The phase diagram of a water solution of DNA and oppositely charged spherical macroions is studied. DNA winds around spheres to form beads-on-a-string complexes resembling the chromatin 10 nm fiber. At small enough concentration of spheres these "artificial chromatin" complexes are negative, while at large enough concentrations of spheres the charge of DNA is inverted by the adsorbed spheres. Charges of complexes stabilize their solutions. In the plane of concentrations of DNA and spheres the phases with positive and negative complexes are separated by another phase, which contains the condensate of neutral DNA-spheres complexes. Thus when the concentration of spheres grows, DNA-spheres complexes experience condensation and resolubilization (or reentrant condensation). Phenomenological theory of the phase diagram of reentrant condensation and charge inversion is suggested. Parameters of this theory are calculated by microscopic theory. It is shown that an important part of the effect of a monovalent salt on the phase diagram can be described by the nontrivial renormalization of the effective linear charge density of DNA wound around a sphere, due to the Onsager-Manning condensation. We argue that our phenomenological phase diagram or reentrant condensation is generic to a large class of strongly asymmetric electrolytes. Possible implication of these results for the natural chromatin are discussed.Comment: Many corrections to text. SUbmitted to J. Chem. Phy

Smilansky's model of irreversible quantum graphs, II: the point spectrum

In the model suggested by Smilansky one studies an operator describing the interaction between a quantum graph and a system of K one-dimensional oscillators attached at different points of the graph. This paper is a continuation of our investigation of the case K>1. For the sake of simplicity we consider K=2, but our argument applies to the general situation. In this second paper we apply the variational approach to the study of the point spectrum.Comment: 18 page

Improving subject knowledge and subject pedagogic knowledge in employment based secondary initial teacher training in England

Each year in England about 6,000 trainee teachers qualify by undertaking an employment-based initial teacher training route (EBITT), where training is mainly school based. Government inspectors have found that trainees on this route are weaker in subject knowledge and subject pedagogic knowledge compared to trainees following the more traditional one year training course (PGCE) of which about a third of course time is University based. EBITT providers are currently seeking to improve the subject knowledge aspect of training. To support this work the TDA have published a model for developing trainees' subject knowledge for teaching and suggest that providers review their provision against the model. In addition EBITT providers must also meet a new requirement that the total training time should be a minimum of 60 days. This new requirement presents a challenge to EBITT providers as most of the subject knowledge enhancement will have to be school-based. This paper seeks to find out: - how trainee teachers acquire subject and subject pedagogic knowledge while based in a school and - whether teaching staff in schools have the required subject and subject pedagogic knowledge and skills for this enhanced role. Data have been collected from trainees, school-based mentors, school-based Initial Teacher Training Coordinators and University assessors over a one year period. Data about the way trainees acquire subject knowledge was interpreted against the TDA model. The study finds that: - trainees acquire subject and subject pedagogic knowledge in a variety of highly individualistic ways that suggests that the TDA model only partially explains what is happening in practice and - there is a significant training need to ensure schools are well equipped to deliver high quality subject focussed training.</p

The mass of dwarf spheroidal galaxies and the missing satellite problem

We present the results from a suite of N-body simulations of the tidal stripping of two-component dwarf galaxies comprising some stars and dark matter. We show that recent kinematic data from the local group dwarf spheroidal (dSph) galaxies suggests that dSph galaxies must be sufficiently massive ($10^9 - 10^{10}$M$_\odot$) that tidal stripping is of little importance for the stars. We discuss the implications of these massive dSph galaxies for cosmology and galaxy formation.Comment: 4 pages, 1 figure, to appear in the proceedings of the IAUC198 "Near-Field Cosmology with Dwarf Elliptical Galaxies", H. Jerjen & B. Binggeli (eds.). Comments welcom

The tidal stripping of satellites

We present an improved analytic calculation for the tidal radius of satellites and test our results against N-body simulations. The tidal radius in general depends upon four factors: the potential of the host galaxy, the potential of the satellite, the orbit of the satellite and {\it the orbit of the star within the satellite}. We demonstrate that this last point is critical and suggest using {\it three tidal radii} to cover the range of orbits of stars within the satellite. In this way we show explicitly that prograde star orbits will be more easily stripped than radial orbits; while radial orbits are more easily stripped than retrograde ones. This result has previously been established by several authors numerically, but can now be understood analytically. For point mass, power-law (which includes the isothermal sphere), and a restricted class of split power law potentials our solution is fully analytic. For more general potentials, we provide an equation which may be rapidly solved numerically. Over short times (\simlt 1-2 Gyrs $\sim 1$ satellite orbit), we find excellent agreement between our analytic and numerical models. Over longer times, star orbits within the satellite are transformed by the tidal field of the host galaxy. In a Hubble time, this causes a convergence of the three limiting tidal radii towards the prograde stripping radius. Beyond the prograde stripping radius, the velocity dispersion will be tangentially anisotropic.Comment: 10 pages, 5 figures. Final version accepted for publication in MNRAS. Some new fully analytic tidal radii have been added for power law density profiles (including the isothermal sphere) and some split power law

VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy- Terminal NRP1 Fragments That Regulate Angiogenic Signaling

OBJECTIVE: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism for regulating angiogenesis, but the role of NRP1 proteolysis and the NRP1 species generated by cleavage in endothelial cells is not known. To characterize NRP1 proteolytic cleavage in endothelial cells, determine the mechanism, and investigate the role of NRP1 cleavage in regulation of endothelial cell function. APPROACH AND RESULTS: NRP1 species comprising the carboxy (C)-terminal and transmembrane NRP1 domains but lacking the ligand-binding A and B regions are constitutively expressed in endothelial cells. Generation of these C-terminal domain NRP1 proteins is upregulated by phorbol ester and Ca2+ ionophore, and reduced by pharmacological inhibition of metalloproteinases, by small interfering RNA-mediated knockdown of 2 members of ADAM (a disintegrin and metalloproteinase) family, ADAMs 9 and 10, and by a specific ADAM10 inhibitor. Furthermore, VEGF upregulates expression of these NRP1 species in an ADAM9/10-dependent manner. Transduction of endothelial cells with adenoviral constructs expressing NRP1 C-terminal domain fragments inhibited VEGF-induced phosphorylation of VEGFR2 (VEGF receptor tyrosine kinase)/KDR and decreased VEGF-stimulated endothelial cell motility and angiogenesis in coculture and aortic ring sprouting assays. CONCLUSIONS: These findings identify novel NRP1 species in endothelial cells and demonstrate that regulation of NRP1 proteolysis via ADAMs 9 and 10 is a new regulatory pathway able to modulate VEGF angiogenic signaling