53 research outputs found
Production of interleukin-10 by alveolar macrophages from lung cancer patients
AbstractInterleukin (IL)-10 is known to be an autoregulatory factor of functions of monocyte macrophages. The purpose of this study was to determine whether IL-10 production by alveolar macrophages (AMs) is altered in patients with lung cancer. AMs were obtained by bronchoalveolar lavage from 25 patients with lung cancer and 14 control patients. The production of IL-10 by AMs was quantitated by enzyme immunoassay with or without stimulation with lipopolysaccharide (LPS). No significant difference in spontaneous and LPS-stimulated IL-10 production by AMs was observed between lung cancer patients and control patients (mean ± sem; 288·0 ± 56·7 vs. 249·6 ± 58·4 pg ml−1). IL-10 production of LPS-stimulated AMs was not impaired even in lung cancer patients with systemic metastasis. IL-4 failed to suppress LPS-induced production of IL-10 by AMs both in control patients and in lung cancer patients. In eight patients with lung cancer, IL-10 production by AMs was estimated before and after systemic chemotherapy and IL-10 production by LPS-stimulated AMs tended to increase after systemic chemotherapy from 152·3 ± 51·9 to 278·0 ± 112·8 pg ml−1. As IL-10 is a potent inhibitor of tumour angiogenesis, an important process of tumour progression, these results suggest that, even in advanced cancer patients, macrophages can produce potent angiogenesis inhibitor and systemic chemotherapy may augment this inhibitory activity in the lung
Control of ferroelectric polarization via uniaxial pressure in the spin-lattice-coupled multiferroic CuFe1-xGaxO2
We have demonstrated that ferroelectric polarization in a spin-driven
multiferroic CuFe1-xGaxO2 with x = 0.035 can be controlled by the application
of uniaxial pressure. Our neutron diffraction and in-situ ferroelectric
polarization measurements have revealed that the pressure dependence of the
ferroelectric polarization is explained by repopulation of three types of
magnetic domains originating from the trigonal symmetry of the crystal. We
conclude that the spin-driven anisotropic lattice distortion and the fixed
relationship between the directions of the magnetic modulation wave vector and
the ferroelectric polarization are the keys to this spin-mediated piezoelectric
effect.Comment: 4 pages, 4 figure
Association between neck and shoulder pain, back pain, low back pain and body composition parameters among the Japanese general population
Intervention based on BASNEF model increases exclusive breastfeeding in preterm infants in Iran: a randomized controlled trial
Crystal Field Excitations in the Breathing Pyrochlore Antiferromagnet Ba <sub>3</sub> Yb <sub>2</sub> Zn <sub>5</sub> O <sub>11</sub>
Epithelial Cell Rests of Malassez Modulate Cell Proliferation, Differentiation and Apoptosis via Gap Junctional Communication under Mechanical Stretching in vitro
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