Partial cavity instabilities

This paper reviews some of the literature on partial cavity instabilities on single hydrofoils and then summarizes the striking differences in the appearance and behavior of partial cavities on swept foils (as opposed to two-dimensional, unswept foils) as rcently highlighted by de Lange et al. (1994) and Laberteaux and Ceccio (1998). These demonstrate the importance of the spanwise evolution of the re-entrant jet, and the consequences for the characteristics of the cavity closure flow. It is suggested in this paper that several variants of this evolution can be seen in the photographs of cavitation on single hydrofoils foils and on propellers. What is common to many of these variants is that, the spanwise evolution of the cavity and the re-entrant jet can give rise to conditions at some particular spanwise location(s) which initiate partial cavity instability. In this paper we present information on an instability that was observed to occur on a cavitating propeller of modern US Navy design. Detailed photographic examinations show that the instability oscillations involve spanwise development of a re-entrant jet and behavior similar to that of the partial cavity oscillations previously observed on two-dimensional foils

Surge Instability on a Cavitating Propeller

This study details experiments investigating a previously unrecognized surge instability on a cavitating propeller in a water tunnel. The surge instability is explored through visual observation of the cavitation on the propeller blades and in the tip vortices. Similarities between the instability and previously documented cavitation phenomena are noted. Measurements of the radiated pressure are obtained, and the acoustic signature of the instability is identified. The magnitudes of the fluctuating pressures are very large, presumably capable of producing severe hull vibration on a ship. The origins of this instability are explored through separate investigation of the cavitation dynamics and the response of the water tunnel to volumetric displacement in the working section. Experiments are conducted to quantify the dynamics of the propeller cavitation. Finally, a model is developed for the complete system, incorporating both the cavitation and facility dynamics. The model predicts active system dynamics (linked to the mass flow gain factor familiar in the context of pump dynamics) and therefore potentially unstable behavior for two distinct frequency ranges, one of which appears to be responsible for the instability

IL1RL1 Gene Variants and Nasopharyngeal IL1RL-a Levels Are Associated with Severe RSV Bronchiolitis: A Multicenter Cohort Study

Targets for intervention are required for respiratory syncytial virus (RSV) bronchiolitis, a common disease during infancy for which no effective treatment exists. Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma. Human IL1RL1 encodes three isoforms, including soluble IL1RL1-a, that can influence IL33 signalling by modifying inflammatory responses to epithelial damage. We hypothesized that IL1RL1 gene variants and soluble IL1RL1-a are associated with severe RSV bronchiolitis.We studied the association between RSV and 3 selected IL1RL1 single-nucleotide polymorphisms rs1921622, rs11685480 or rs1420101 in 81 ventilated and 384 non-ventilated children under 1 year of age hospitalized with primary RSV bronchiolitis in comparison to 930 healthy controls. Severe RSV infection was defined by need for mechanical ventilation. Furthermore, we examined soluble IL1RL1-a concentration in nasopharyngeal aspirates from children hospitalized with primary RSV bronchiolitis. An association between SNP rs1921622 and disease severity was found at the allele and genotype level (p = 0.011 and p = 0.040, respectively). In hospitalized non-ventilated patients, RSV bronchiolitis was not associated with IL1RL1 genotypes. Median concentrations of soluble IL1RL1-a in nasopharyngeal aspirates were >20-fold higher in ventilated infants when compared to non-ventilated infants with RSV (median [and quartiles] 9,357 [936-15,528] pg/ml vs. 405 [112-1,193] pg/ml respectively; p<0.001).We found a genetic link between rs1921622 IL1RL1 polymorphism and disease severity in RSV bronchiolitis. The potential biological role of IL1RL1 in the pathogenesis of severe RSV bronchiolitis was further supported by high local concentrations of IL1RL1 in children with most severe disease. We speculate that IL1RL1a modifies epithelial damage mediated inflammatory responses during RSV bronchiolitis and thus may serve as a novel target for intervention to control disease severity

The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation

Respiratory syncytial virus (RSV) is an important cause of acute respiratory disease in infants, immunocompromised subjects and the elderly. However, it is unclear why most primary RSV infections are associated with relatively mild symptoms, whereas some result in severe lower respiratory tract infections and bronchiolitis. Since RSV hospitalization has been associated with respiratory bacterial co-infections, we have tested if bacterial Toll-like receptor (TLR) agonists influence RSVA2- GFP infection in human primary cells or cell lines. The synthetic bacterial lipopeptide Pam3-Cys-Ser-Lys4 (Pam3CSK4), the prototype ligand for the heterodimeric TLR1/TLR2 complex, enhanced RSV infection in primary epithelial, myeloid and lymphoid cells. Surprisingly, enhancement was optimal when lipopeptides and virus were added simultaneously, whereas addition of Pam3CSK4 immediately after infection had no effect. We have identified two structurally related lipopeptides without TLR-signaling capacity that also modulate RSV infection, whereas Pam3CSK4-reminiscent TLR1/2 agonists did not, and conclude that modulation of infection is independent of TLR activation. A similar TLR-independent enhancement of infection could also be demonstrated for wild-type RSV strains, and for HIV-1, measles virus and human metapneumovirus. We show that the effect of Pam3CSK4 is primarily mediated by enhanced binding of RSV to its target cells. The Npalmitoylated cystein

Adaptation of an apple sooty blotch and flyspeck warning system for the Upper Midwest United States

A warning system for sooty blotch and flyspeck (SBFS) of apple, developed in the southeastern United States, uses cumulative hours of leaf wetness duration (LWD) to predict the timing of the first appearance of signs. In the Upper Midwest United States, however, this warning system has resulted in sporadic disease control failures. The purpose of the present study was to determine whether the warning system`s algorithm could be modified to provide more reliable assessment of SBFS risk. Hourly LWD, rainfall, relative humidity (RH), and temperature data were collected from orchards in Iowa, North Carolina, and Wisconsin in 2005 and 2006. Timing of the first appearance of SBFS signs was determined by weekly scouting. Preliminary analysis using scatterplots and boxplots suggested that Cumulative hours of RH >= 97% could be a useful predictor of SBFS appearance. Receiver operating characteristic curve analysis was used to compare the predictive performance of cumulative LWD and cumulative hours of RH >= 97%. Cumulative hours of RH >= 97% was a more conservative and accurate predictor than cumulative LWD for 15 site years in the Upper Midwest, but not for four site years in North Carolina. Performance of the SBFS warning system in the Upper Midwest and climatically similar regions may be improved if cumulative hours of RH >= 97% were substituted for cumulative LWD to predict the first appearance of SBFS

Physiological responses of walleyes to live-release angling tournaments

This study examines the physiological impacts of live-release angling tournament practices on walleyes Sander vitreus (formerly Stizostedion vitreum). Blood and white muscle samples were taken from walleyes following the weigh-in at several live-release angling tournaments in southern Ontario. The tournament walleyes had significantly elevated plasma cortisol levels in comparison with those of the control walleyes, indicating that tournament practices elicit a significant stress response in the tournament fish. Increased creatine phosphokinase and lactate dehydrogenase activities revealed that walleyes experience a moderate degree of cellular damage during live-release angling tournaments. In contrast to recent research with largemouth bass Micropterus salmoides, the tournament walleyes showed evidence of plasma ion loss. The tournament walleyes also experienced dramatic reductions in white muscle energy stores (phosphocreatine, ATP, and glycogen) and corresponding increases in plasma and white muscle lactate levels when compared with those of the control fish. These metabolic changes were similar in magnitude to the changes previously observed in largemouth bass following tournaments and suggest that current tournament procedures may commonly cause relatively large bouts of anaerobic metabolism in fish