El proceso de aceptación y adaptación a la bisexualidad a través de la terapia cognitivo-conductual con enfoque afirmativo: estudio de caso único

Las personas del colectivo LGBTIQ+ vivencian en su día a día diversas situaciones de estigmatización social, repercutiendo en su bienestar emocional y su salud mental. Estas actitudes negativas pueden moderar los sentimientos y percepciones de aquellas que pasan a formar parte del colectivo, como ocurre con la bisexualidad. En este estudio se presenta un acercamiento cognitivo-conductual con enfoque afirmativo en un caso de adaptación y aceptación de una usuaria que recientemente “redescubre” su orientación bisexual. A lo largo de 12 sesiones, a través de la psicoeducación, la restructuración cognitiva, el entrenamiento en asertividad y la exposición; se consigue reducir en la usuaria las diferentes problemáticas detectadas. Se consigue reducir los sentimientos de tristeza y ansiedad, se reduce el estrés percibido en situaciones problemáticas y se optimizan sus recursos en gestión emocional, obteniendo mejores resultados cuantitativos en la Escala de Evaluación de Resultados. Se concluye que este tipo de abordajes psicoterapéuticos son efectivo

Risk factors for suicide in transgender population: a bibliographical review

El suicidio supone la primera causa de muerte no natural en España, y la segunda causa general en la población joven. La pertenencia a un grupo social minoritario aumenta la vulnerabilidad ante el suicidio. Este es el caso del colectivo LGBTIQ+, y concretamente, de las personas trans. El objetivo de este estudio fue revisar la literatura científica referente al suicidio en las personas trans, incluyendo factores de riesgo específicos y de protección para mejorar los programas de prevención e intervención. La literatura localizada para el estudio es escasa, en especial en el ámbito de la prevención y la intervención. Se concluye que este colectivo es más vulnerable ante el suicidio por factores como el estigma social, las diversas situaciones vividas a lo largo del ciclo vital, y los problemas psicológicos asociados. Se ha encontrado que la ideación suicida es frecuente en población trans. Su aparición precoz correlaciona positivamente con la aparición de conductas suicidas, por lo que se propone mejorar los programas de prevención. Entre las intervenciones con mayor eficacia se encuentran las técnicas dirigidas a la autoafirmación de género y la construcción de una red de apoyo social.Suicide is the leading cause of unnatural death in Spain, and the second one in the young population in general. Belonging to a minority social group increases vulnerability to suicide. This is the case of the LGBTIQ+group, and specifically, of transgender people. The aim of this study was to review the scientific literature on suicide in transgender population, including risk and protective factors in order to improve prevention and intervention programmes. The literature located for the study is scarce, especially in the field of prevention and intervention. Its early appearance correlates positively with the appearance of suicidal behaviour, which is why it is proposed to improve prevention programmes. Among the interventions that stand out as most effective are techniques aimed at gender self-affirmation and building a social support network. It is concluded that transgender people are more vulnerable to suicide due to factors such as social stigma, challenging situations experienced throughout the life cycle, and associated psychological problems. Suicidal ideation has been found to be frequent in the transgender population

Factores de riesgo para el suicidio en población trans: una revisión bibliográfica

Suicide is the leading cause of unnatural death in Spain, and the second one in the young population in general. Belonging to a minority social group increases vulnerability to suicide. This is the case of the LGBTIQ+ group, and specifically, of transgender people. The aim of this study was to review the scientific literature on suicide in transgender population, including risk and protective factors in order to improve prevention and intervention programmes. The literature located for the study is scarce, especially in the field of prevention and intervention. It is concluded that transgender people are more vulnerable to suicide due to factors such as social stigma, challenging situations experienced throughout the life cycle, and associated psychological problems. Suicidal ideation has been found to be frequent in the transgender population. Its early appearance correlates positively with the appearance of suicidal behaviour, which is why it is proposed to improve prevention programmes. Among the interventions that stand out as most effective are techniques aimed at gender self-affirmation and building a social support network.El suicidio supone la primera causa de muerte no natural en España, y la segunda causa general en la población joven. La pertenencia a un grupo social minoritario aumenta la vulnerabilidad ante el suicidio. Este es el caso del colectivo LGBTIQ+, y concretamente, de las personas trans. El objetivo de este estudio fue revisar la literatura científica referente al suicidio en las personas trans, incluyendo factores de riesgo específicos y de protección para mejorar los programas de prevención e intervención. La literatura localizada para el estudio es escasa, en especial en el ámbito de la prevención y la intervención. Se concluye que este colectivo es más vulnerable ante el suicidio por factores como el estigma social, las diversas situaciones vividas a lo largo del ciclo vital, y los problemas psicológicos asociados. Se ha encontrado que la ideación suicida es frecuente en población trans. Su aparición precoz correlaciona positivamente con la aparición de conductas suicidas, por lo que se propone mejorar los programas de prevención. Entre las intervenciones con mayor eficacia se encuentran las técnicas dirigidas a la autoafirmación de género y la construcción de una red de apoyo social.&nbsp

Current Trends in Functional Imaging of Pheochromocytomas and Paragangliomas

Most pheochromocytomas/paragangliomas should be evaluated with anatomical imaging (computed tomography or magnetic resonance imaging) followed by functional imaging (nuclear medicine modalities). Functional imaging assures that the tumor is indeed a pheochromocytoma/paraganglioma and enables more thorough localization, especially detecting as many lesions as possible (in particular for metastatic disease). Functional imaging for pheochromocytomas/paragangliomas, can use radiolabled ligands specific for pathways of synthesis, metabolism, and inactivation of catecholamines or nonspecific ligands. In an overview of the available nuclear medicine modalities, we summarize the accumulated experience and recommend when functional imaging should be applied to patients with pheochromocytoma/paraganglioma.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74881/1/annals.1353.041.pd

DUET: A phase 2 study evaluating the efficacy and safety of sparsentan in patients with FSGS

Background: We evaluated and compared the effects of sparsentan, a dual endothelin type A (ETA) and angiotensin II type 1 receptor antagonist, with those of the angiotensin II type 1 receptor antagonist irbesartan in patients with primary FSGS. Methods: In this phase 2, randomized, double-blind, active-control Efficacy and Safety of Sparsentan (RE-021), a Dual Endothelin Receptor and Angiotensin Receptor Blocker, in Patients with Focal Segmental Glomerulosclerosis (FSGS): A Randomized, Double-blind, Active-Control, Dose-Escalation Study (DUET), patients aged 8-75 yearswith biopsy-proven FSGS, eGFR>30ml/min per 1.73m2, and urinary protein-to-creatinine ratio (UP/C)≥1.0 g/g received sparsentan (200, 400, or 800 mg/d) or irbesartan (300mg/d) for 8 weeks, followed by open-label sparsentan only. End points atweek 8 were reduction from baseline inUP/C(primary) and proportion of patients achieving FSGS partial remission end point (FPRE) (UP/C:≤1.5 g/g and>40%reduction [secondary]). Results: Of 109 patients randomized, 96 received study drugs and had baseline and week 8 UP/C measurements. Sparsentan-treated patients had greater reductions in UP/C than irbesartan-treated patients didwhen all doses (45%versus 19%; P=0.006) or the 400 and 800mg doses (47%versus 19%; P=0.01) were pooled for analysis. The FSGS partial remission end point was achieved in 28% of sparsentan-treated and 9% of irbesartan-treated patients (P=0.04). After 8 weeks of treatment, BP was reduced with sparsentan but not irbesartan, and eGFR was stable with both treatments. Overall, the incidence of adverse events was similar between groups. Hypotension and edema were more common among sparsentan-treated patients but did not result in study withdrawals. Conclusions: Patients with FSGS achieved significantly greater reductions in proteinuria after 8 weeks of sparsentan versus irbesartan. Sparsentan was safe and well tolerated

Evaluation of a Workplace Treadmill Desk Intervention: A Randomized Controlled Trial

OBJECTIVE: To evaluate the effectiveness of a 3-month treadmill desk intervention in eliciting changes in physical activity and sedentary behavior among overweight/obese office workers. METHODS: A randomized controlled trial was conducted among overweight/obese office workers (n=41; mean age = 40.1 ± 10.1 years) at a private workplace. Participants were randomly assigned to a shared-treadmill desk intervention (n=21) or a usual working condition control group (n=20). Accelerometer-determined physical activity and sedentary behavior were measured before and after the intervention. RESULTS: Compared with the control group, the intervention group increased daily steps (1622 steps/day; p=0.013) and light physical activity (1.6 minutes/hour; p=0.008), and decreased sedentary time (−3.6 minutes/hour; p=0.047) during working hours. CONCLUSIONS: Shared-treadmill desks in the workplace can be effective at promoting favorable changes in light physical activity (specifically 40-99 steps/minute) and sedentary behavior among overweight/obese office workers.This is a non-final version of an article. The article is copyrighted by the American College of Occupational and Environmental Medicine and published by Lippincott Williams & Wilkins. It can be found as published in final form at: http://journals.lww.com/joem/pages/default.asp

Mutations associated with succinate dehydrogenase D-related malignant paragangliomas.

Contains fulltext : 70804.pdf (publisher's version ) (Closed access)OBJECTIVE: Hereditary paraganglioma (PGL) syndromes result from germline mutations in genes encoding subunits B, C and D of the mitochondrial enzyme succinate dehydrogenase (SDHB, SDHC and SDHD). SDHB-related PGLs are known in particular for their high malignant potential. Recently, however, malignant PGLs were also reported among a small minority of Dutch carriers of the SDHD founder mutation D92Y. The aim of the study was to investigate which SDHD mutations are associated with malignant PGL. DESIGN: Case histories; collaborative study between referral centres in France, the USA, and the Netherlands. PATIENTS: Six unrelated patients with metastatic PGLs of either sympathetic or parasympathetic origin. MEASUREMENTS: Assessment of SDHD mutations underlying malignant PGL. RESULTS: Germline SDHD mutations underlying metastatic PGL were G148D, Y114X, L85X, W43X, D92Y, and IVS2+5G-->A. CONCLUSION: Our findings indicate that malignant SDHD-related PGL is associated with several mutations besides D92Y