Photon radiation damage in high purity silicon and LEC Si gallium arsenide detectors

Observations have been made of the behaviour of high resistivity silicon and semi-insulating gallium arsenide ionizing radiation detectors after exposure of up to 30 Mrad Co-60 photons. Results are presented on leakage current and deep level defects of the substrate material of photon damage devices. These findings have been related to the charge collection efficiency of the detectors

Defects induced by protons and gamma-rays in semi-insulating GaAs detectors

Semi-insulating gallium arsenide has been irradiated by protons and by gamma-rays with different doses. The irradiation-induced deep level defects have been investigated by current transient spectroscopy to find their energy, capture cross sections and generation rate.Two electron traps at Ec+0.14eV(E13) and Ec-0.70eV(E4) and a hole trap at Ec-0.14eV(H2) in addition to the levels existing before the irradiation have been detected in the irradiated samples. These findings have been related to the performance of gallium arsenide charge particle detectors

Differential risk of non-Hodgkin's lymphoma in Italian patients with primary Sjogren's syndrome

OBJECTIVE: To assess the incidence of non-Hodgkin's lymphoma (NHL) and estimate the relative risk (RR) of developing lymphoproliferative complications in a large population of Italian patients with Sjögren's syndrome (SS) and to ascertain if any difference exists between the north and centre-south of Italy. METHODS: Differential relative risks of NHL were obtained by comparing the number of observed cases with cases identified on the basis of age-sex-time specific incidence rates extracted from regional cancer registries. RESULTS: Among the 331 patients with SS studied, 9 cases of NHL occurred, while no lymphoid malignancy appeared in patients with overlapping connective tissue disease (secondary SS) or in males with primary SS. As the number of NHL cases identified on the basis of the rate in the cancer registries would have been 0.27, the RR is 33.3 (p < 0.001). The incidence rate of NHL in Italian patients with SS is about 5.1/1000 person-years. 5.4/1000 per year in the north of the country and 4.8/1000 per year in the centre-south. The relative risks are, respectively, 34.7 and 32.5. CONCLUSION: Italian patients with primary SS have increased risk of developing NHL. In this group, the absence of a significant difference between the north and the centre-south of Italy contrasts with the higher incidence of NHL in the general population of northern regions and strengthens the direct connection between primary SS and NHL

Bitter taste receptors as targets for tocolytics in preterm labor therapy

Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and consequently identifying novel targets for tocolytics are essential for more successful management of PTB. Here we report that myometrial cells from human and mouse express bitter taste receptors (TAS2Rs) and their canonical signaling components (i.e., G-protein gustducin and phospholipase C beta2). Bitter tastants can completely relax myometrium precontracted by different uterotonics. In isolated single mouse myometrial cells, a phenotypical bitter tastant (chloroquine, ChQ) reverses the rise in intracellular Ca2+ concentration ([Ca2+]i) and cell shortening induced by uterotonics, and this reversal effect is inhibited by pertussis toxin and by genetic deletion of alpha-gustducin. In human myometrial cells, knockdown of TAS2R14 but not TAS2R10 inhibits ChQ\u27s reversal effect on an oxytocin-induced rise in [Ca2+]i Finally, ChQ prevents mouse PTBs induced by bacterial endotoxin LPS or progesterone receptor antagonist mifepristone more often than current commonly used tocolytics, and this prevention is largely lost in alpha-gustducin knockout mice. Collectively, our results reveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound relaxation of myometrium precontracted by a broad spectrum of contractile agonists, and that targeting TAS2Rs is an attractive approach to developing effective tocolytics for PTB management

Gallium arsenide pixel detectors for medical imaging

Gallium arsenide pixel detectors processed on a 200 mu m Semi-Insulating (SI) Hitachi substrate were bump-bended to the Omega3 electronics developed at CERN for high energy physics [1]. The pixel dimensions are 50 mu m x 500 mu m for a total of 2048 cells and an active area of similar to 0.5 cm(2). Our aim is to use this system for medical imaging. We report the results obtained after irradiation of the detector with different X-ray sources on phantoms with different contrasts. The system showed good sensitivity to X-rays from Am-241 (60 keV) and Cd-109 (22.1 keV). It is also sensitive to p-particles from Sr-90 as well as from P-32 which is used as a tracer for autoradiography applications. The inherent high absorption efficiency of GaAs associated with the self-triggering capabilities of the pixel readout system reduced considerably the acquisition time compared with traditional systems based on silicon or emulsions. The present configuration is not optimised for X-ray imaging. The reduction of the pixel dimensions to 200 mu m x 200 mu m together with the integration of a counter in the pixel electronics would make the detector competitive for applications like mammography or dental radiology. For certain applications in biochemistry, such as DNA sequencing, where good spatial resolution is required only in one direction, the present setup should allow the best spatial resolution available up to now with respect to other digital autoradiographic systems. DNA sequencing tests are now under way

Gallium arsenide pixel detectors for medical imaging

Gallium arsenide pixel detectors processed on a 200 mu m Semi-Insulating (SI) Hitachi substrate were bump-bended to the Omega3 electronics developed at CERN for high energy physics [1]. The pixel dimensions are 50 mu m x 500 mu m for a total of 2048 cells and an active area of similar to 0.5 cm(2). Our aim is to use this system for medical imaging. We report the results obtained after irradiation of the detector with different X-ray sources on phantoms with different contrasts. The system showed good sensitivity to X-rays from Am-241 (60 keV) and Cd-109 (22.1 keV). It is also sensitive to p-particles from Sr-90 as well as from P-32 which is used as a tracer for autoradiography applications. The inherent high absorption efficiency of GaAs associated with the self-triggering capabilities of the pixel readout system reduced considerably the acquisition time compared with traditional systems based on silicon or emulsions. The present configuration is not optimised for X-ray imaging. The reduction of the pixel dimensions to 200 mu m x 200 mu m together with the integration of a counter in the pixel electronics would make the detector competitive for applications like mammography or dental radiology. For certain applications in biochemistry, such as DNA sequencing, where good spatial resolution is required only in one direction, the present setup should allow the best spatial resolution available up to now with respect to other digital autoradiographic systems. DNA sequencing tests are now under way