Izlučivanje žive i kadmija putem žuči

The own kinetic data on the biliary excretion of different mercury species and cadmium are presented. The role of enterohepatic circulation, mechanisms of biliary excretion and mobilization of Cd2+ and Hg2+ with selected chelating agents are discussed. The experimental results are confronted with scarce human data available from own laboratory and literature.U radu su izneseni vlastiti rezultati istraživanja izlučivanja žive i kadmija putem žuči. Raspravlja se o enterohepatičkoj cirkulaciji, mehanizmu izlučivanja putem žuči, kao i o mobilizaciji Cd2+ i Hg2+ pomoću odgovarajućih kelirajućih supstancija. Dobiveni rezultati uspoređeni su s rijetkim podacima dobivenim na ljudima koji su bili dostupni u našem laboratoriju i u literaturi

Blood lead, cadmium and mercury among children from urban, industrial and rural areas of Fez Boulemane Region (Morocco): Relevant factors and early renal effects

Objectives: To describe blood lead (Pb-B), cadmium (Cd-B) and mercury (Hg-B) levels in children living in urban, industrial and rural areas in Fez city (north of Morocco) and to identify the determinants and some renal effects of exposure. Material and Methods: The study was conducted from June 2007 to January 2008 in 209 school children (113 girls, 96 boys), aged 6-12 years, from urban, industrial and rural areas in Fez city. Interview and questionnaires data were obtained. Blood and urinary samples were analyzed. Results: The mean of blood lead levels (Pb-B) in our population was 55.53 μg/l (range: 7.5-231.1 μg/l). Children from the urban area had higher blood lead levels (BLLs) mean (82.36 μg/l) than children from industrial and rural areas (48.23 and 35.99 μg/l, respectively); with no significant difference between boys and girls. BLLs were associated with traffic intensity, passive smoking and infancy in the urban area. The mean of blood cadmium levels (BCLs) was 0.22 μg/l (range: 0.06-0.68 μg/l), with no difference between various areas. Rural boys had higher BCLs mean than rural girls, but no gender influence was noticed in the other areas. BCLs were associated with the number of cigarettes smoked at children's homes. The blood mercury levels (BMLs) mean was 0.49 μg/l (range: 0.01-5.31 μg/l). The BMLs mean was higher in urban and industrial areas than in the rural area with no gender-related difference. BMLs were associated with amalgam fillings and infancy in the urban area. About 8% of the children had BLLs ≥ 100 μg/l particularly in the urban area, microalbuminuria and a decrease in height were noticed in girls from the inner city of Fez and that can be related to high BLLs (89.45 μg/l). Conclusions: There is a need to control and regulate potential sources of contamination by these trace elements in children; particularly for lead

Excretion of cadmium through bile and intestinal wall in rats

Cikrt, M., and Tichý, M. (1974).British Journal of Industrial Medicine,31, 134-139. Excretion of cadmium through bile and intestinal wall in rats. The excretion of Cd(2+) through the bile and intestinal wall after intravenous administration of CdCl(2) in non-toxic doses (67, 90, and 120 μg of Cd(2+) per rat) was studied in rats. The cumulative biliary excretion reached 24 hours after administration of the 67 μg dose was 0·83%, after 90 μg 1·18%, and after the 120 μg dose 5·68% of the amount given. The highest excretion rate of Cd(2+) was detected between 15 and 30 minutes after administration. There was no difference in the excretion through intestinal wall between the 67 and 120 μg doses of Cd(2+) per rat. The mean amount of cadmium found in the contents of the entire gastrointestinal tract and faeces was 5·5% of the administered dose. Using polyacrylamide gel disc electrophoresis it was found that Cd(2+) is bound with at least two different components of the rat bile