34 research outputs found
Exhaled 8-isoprostane in sarcoidosis: relation to superoxide anion production by bronchoalveolar lavage cells
Factors associated with poor glycaemic control in type 2 diabetic elderly patients with mild cognitive impairment
Introduction and objective. Recently, data has indicated a higher incidence of mild cognitive impairment (MCI) in patients
with diabetes. Old age is a risk factor for cognitive deterioration and dementia. The aim of the study was to find the factors
associated with poor glycaemic control in type 2 diabetic elderly patients with MCI.
Materials and method. A cross-sectional study was conducted on 87 diabetic patients with MCI in an outpatient clinic. All
subjects were screened for MCI using the Montreal Cognitive Assessment (MoCA). Detailed medical history and collection
of blood test samples were performed.
Results. 83.9% of participants had poor glycaemic control. A positive correlation was found between HbA1c level and
number of visit to a doctor per year, number of co-morbidities, duration of T2DM, triglycerides and fasting glucose level; and
a negative correlation between HbA1c level and years of education, HDL cholesterol level and MoCA score. The univariate
logistic regression models revealed factors which are associated with poor glycemic control are: less years of education,
higher no of visit to doctor per year, increased number of co-morbidities, presence of CVD, retinopathy, higher levels of
triglycerides and fasting glucose, lower level of HDL cholesterol, lower MoCA score. Multivariable model revealed that
higher plasma levels of fasting glucose and triglycerides are significant predictors.
Conclusions. There is a high prevalence of poor glycemic control patients among elderly diabetics with MCI. Higher plasma
levels of fasting glucose and triglycerides seems to be the most important predictors of poor glycemic control, however
father larger studies are needed to elucidate these relationships