Long range correlations in DNA : scaling properties and charge transfer efficiency

We address the relation between long range correlations and charge transfer efficiency in aperiodic artificial or genomic DNA sequences. Coherent charge transfer through the HOMO states of the guanine nucleotide is studied using the transmission approach, and focus is made on how the sequence-dependent backscattering profile can be inferred from correlations between base pairs.Comment: Submitted to Phys. Rev. Let

Characterizing the human postural control system using detrended fluctuation analysis

AbstractDetrended fluctuation analysis is used to study the behaviour of the time series of the position of the center of pressure, output from the activity of a human postural control system. The results suggest that these trajectories present a crossover in their scaling properties from persistent (for high frequencies, short-range time scale) to anti-persistent (for low frequencies, long-range time scale) behaviours. The values of the scaling exponent found for the persistent parts of the trajectories are very similar for all the cases analysed. The similarity of the results obtained for the measurements done with both eyes open and both eyes closed indicate either that the visual system may be disregarded by the postural control system, while maintaining quiet standing, or that the control mechanisms associated with each type of information (visual, vestibular and somatosensory) cannot be disentangled with this technique

Aula invertida gamificada en estudiantes de magisterio de educación primaria

Ponència presentada al XXIV Congreso Internacional EDUTEC, celebrat del 10 al 12 de novembre de 2021La presente comunicación se centra en dos conceptos clave. Por un lado, la gamificación, una estrategia didáctica que traslada elementos y estructuras del juego al ámbito educativo con la intención de motivar a los estudiantes, y por otro, el flipped learning, un modelo educativo que desplaza el trabajo de ciertos aprendizajes fuera del aula aprovechando así el tiempo en clase para otro tipo de dinámicas. Esta investigación, que forma parte de un estudio más amplio de design-based research (DBR), pretende analizar la motivación y satisfacción de los estudiantes del grado de Educación Primaria, tras la implementación de una intervención didáctica de aula invertida gamificada empleada para trabajar el tema de pensamiento computacional. Para ello, se llevó a cabo un proyecto que comprendía siete fases (motivación, explicación del proyecto, investigación y puesta en práctica, reflexión, elaboración del producto, presentación del producto final y evaluación del proyecto), y se administró un cuestionario para su evaluación. Los resultados extraídos demuestran la satisfacción de los estudiantes con la propuesta didáctica de aula invertida gamificada, así como una elevada motivación e interés por las actividades, lo cual deberá seguir comprobándose de una manera más amplia en las siguientes fases del proyecto

Onset of Delocalization in Quasi-1D Waveguides with Correlated Surface Disorder

We present first analytical results on transport properties of many-mode waveguides with rough surfaces having long-range correlations. We show that propagation of waves through such waveguides reveals a quite unexpected phenomena of a complete transparency for a subset of propagating modes. These modes do not interact with each other and effectively can be described by the theory of 1D transport with correlated disorder. We also found that with a proper choice of model parameters one can arrange a perfect transparency of waveguides inside a given window of energy of incoming waves. The results may be important in view of experimental realizations of a selective transport in application to both waveguides and electron/optic nanodevices.Comment: RevTex, 4 pages, no figures, few references are adde

WordCluster: detecting clusters of DNA words and genomic elements

<p>Abstract</p> <p>Background</p> <p>Many <it>k-</it>mers (or DNA words) and genomic elements are known to be spatially clustered in the genome. Well established examples are the genes, TFBSs, CpG dinucleotides, microRNA genes and ultra-conserved non-coding regions. Currently, no algorithm exists to find these clusters in a statistically comprehensible way. The detection of clustering often relies on densities and sliding-window approaches or arbitrarily chosen distance thresholds.</p> <p>Results</p> <p>We introduce here an algorithm to detect clusters of DNA words (<it>k-</it>mers), or any other genomic element, based on the distance between consecutive copies and an assigned statistical significance. We implemented the method into a web server connected to a MySQL backend, which also determines the co-localization with gene annotations. We demonstrate the usefulness of this approach by detecting the clusters of CAG/CTG (cytosine contexts that can be methylated in undifferentiated cells), showing that the degree of methylation vary drastically between inside and outside of the clusters. As another example, we used <it>WordCluster </it>to search for statistically significant clusters of olfactory receptor (OR) genes in the human genome.</p> <p>Conclusions</p> <p><it>WordCluster </it>seems to predict biological meaningful clusters of DNA words (<it>k-</it>mers) and genomic entities. The implementation of the method into a web server is available at <url>http://bioinfo2.ugr.es/wordCluster/wordCluster.php</url> including additional features like the detection of co-localization with gene regions or the annotation enrichment tool for functional analysis of overlapped genes.</p