Advanced material against human (Including Covid‐19) and plant viruses: nanoparticles as a feasible strategy

The SARS‐CoV‐2 virus outbreak revealed that these nano‐pathogens have the ability to rapidly change lives. Undoubtedly, SARS‐CoV‐2 as well as other viruses can cause important global impacts, affecting public health, as well as, socioeconomic development. But viruses are not only a public health concern, they are also a problem in agriculture. The current treatments are often ineffective, are prone to develop resistance, or cause considerable adverse side effects. The use of nanotechnology has played an important role to combat viral diseases. In this review three main aspects are in focus: first, the potential use of nanoparticles as carriers for drug delivery. Second, its use for treatments of some human viral diseases, and third, its application as antivirals in plants. With these three themes, the aim is to give to readers an overview of the progress in this promising area of biotechnology during the 2017–2020 period, and to provide a glance at how tangible is the effectiveness of nanotechnology against viruses. Future prospects are also discussed. It is hoped that this review can be a contribution to general knowledge for both specialized and non‐specialized readers, allowing a better knowledge of this interesting topic.REDES‐ANID. Grant Number: 180003 Universidad de La Frontera. Grant Number: DI20‐1003 FAPESP. Grant Numbers: 2018/08194‐2, 2018/02832‐7 CNPq. Grant Numbers: 404815/2018‐9, 313117/2019‐5 CONICYT/FAPESP. Grant Number: 2018/08194‐2 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Grant Numbers: 001, ANID/FONDAP/15130015 FCT. Grant Number: PTDC/CTM‐TEX/28295/2017 FEDER POCI Portugal 2020 program COMPETE. Grant Number: UID/CTM/00264/2019 FCT/MCTE

Expression of the paired box domain Pax7 protein in myogenic cells isolated from the porcine semitendinosus muscle after birth

The paired box domain gene Pax7 plays a pivotal role in satellite cell physiology and may represent one of the candidate genes influencing the dynamic stages of early post-natal growth observed in pig. Quiescent satellite cells express Pax7 and, when activated, they co-express the myogenic bHLH protein MyoD. The aims of this study were to investigate, by immunohistochemistry, the putative differential expression of Pax7 and to ascertain the amount of activated satellite cells (Pax7+/MyoD+) in myogenic cells isolated at different post-natal time points and in adults. Our results indicate that Pax7+ cells represent between 10 and 15% of the whole myogenic cell population found at birth indicating that these cells provide a modest contribution to the development of new fibres. The number of activated satellite cells (Pax7+/MyoD+) was scarce after birth but it was higher respect to adults. An interesting result was that at 1 month after birth the number of Pax7+ cells had increased within the pool of myogenic cells with respect to myogenic cells extracted at birth. We speculate that Pax7 might be one of the molecules involved in controlling the proliferation/differentiation ratio in the pool of satellite cells present in post-natal porcine skeletal muscles. © 2007 Elsevier Ltd. All rights reserved

Zeitlin Truncation of a Shallow Water Quasi‐Geostrophic Model for Planetary Flow

Abstract In this work, we consider a Shallow‐Water Quasi Geostrophic equation on the sphere, as a model for global large‐scale atmospheric dynamics. This equation, previously studied by Verkley (2009, https://doi.org/10.1175/2008jas2837.1) and Schubert et al. (2009, https://doi.org/10.3894/james.2009.1.2), possesses a rich geometric structure, called Lie‐Poisson, and admits an infinite number of conserved quantities, called Casimirs. In this paper, we develop a Casimir preserving numerical method for long‐time simulations of this equation. The method develops in two steps: first, we construct an N‐dimensional Lie‐Poisson system that converges to the continuous one in the limit N → ∞; second, we integrate in time the finite‐dimensional system using an isospectral time integrator, developed by Modin and Viviani (2020, https://doi.org/10.1017/jfm.2019.944). We demonstrate the efficacy of this computational method by simulating a flow on the entire sphere for different values of the Lamb parameter. We particularly focus on rotation‐induced effects, such as the formation of jets. In agreement with shallow water models of the atmosphere, we observe the formation of robust latitudinal jets and a decrease in the zonal wind amplitude with latitude. Furthermore, spectra of the kinetic energy are computed as a point of reference for future studies