10 research outputs found
Effect of Genetic Diversity on the Distribution of Endemic Species of the Genus Silene (Caryophyllaceae) in Saint Katherine Protectorate, Sinai, Egypt
Development of two loquat [Eriobotrya japonica (Thunb.) Lindl.] linkage maps based on AFLPs and SSR markers from different Rosaceae species
Evidence of subtle departures from Mendelian segregation in a wild lesser kestrel (Falco naumanni) population
The distribution of fitness effects of new mutations
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of the molecular clock. It has been studied by two different approaches: mutation accumulation and mutagenesis experiments, and the analysis of DNA sequence data. The proportion of mutations that are advantageous, effectively neutral and deleterious varies between species, and the DFE differs between coding and non-coding DNA. Despite these differences between species and genomic regions, some general principles have emerged: advantageous mutations are rare, and those that are strongly selected are exponentially distributed; and the DFE of deleterious mutations is complex and multi-modal