Ideas que hacen escribir. Los comienzos de José Jiménez Lozano en los periódicos (1956-1969).

El debate sobre el acceso al periodismo, si debe restringirse a los egresados de las facultades o no, encuentra un escollo en las trayectorias de quienes han dejado una clara impronta en el periodismo español reciente. José Jiménez Lozano, licenciado en Derecho, escritor de reconocido prestigio internacional, fue periodista de profesión. La recurrida polémica sobre el parentesco entre periodismo y literatura es siempre actual: se afirma, se niega, se señalan sus diferencias y se quiere encontrar cuál de ellas precede a la otra. Ambas actividades tienen en común muchos elementos. Para empezar, su detonador, ese anhelo que empuja a ciertas personas, a expresarse por medio de la pluma y de hacerlo no en el ámbito privado o de las amistades, sino en las ágoras que las sociedades crean. Entre ellas, el periódico. Periodista y escritor son, ante todo, comunicadores. En su escritura vuelcan su modo de ver la realidad. Advierten sobre ciertos peligros, denuncian actitudes y engaños, aportan conocimientos, esbozan remedios. La pregunta sobre la relación de periodismo y literatura se torna más interesante cuando se abandona el corsé de las teorías y la mirada se detiene en el escritor en singular o en el periodista, con nombre y apellidos. En su obra concreta es donde se podría intentar trazar la línea que defina lo que es periodismo y lo que es literatura, o determinar qué faceta de la persona lleva a la otra. El estudio del inicio del trabajo periodístico de Jiménez Lozano intentará responder a esta pregunta: ¿por qué José Jiménez Lozano se convirtió en periodista? A través de las inquietudes que reflejó en sus primeros años de escritura periodística, se intentará descubrirlo

Shareholder activism and internationalization in the family firm

We present the internationalization of the family firm (FF) as a corporate growth strategy that is sometimes necessary to ensure survival. The different generations running the family firm (GFF) are likely to be constrained, not only by the demands of the business itself, but also by activism from non-management family shareholders. In this paper, we perform an analysis of a sample of Spanish family firms, both domestic and multinational, for the period 2000–2009. The results of this analysis show evidence of a positive relationship between the scope of internationalization and two other variables: family activism (FAI) and life cycle duration of the family firm (DLFF). When it comes to seeking alternative ways to create economic value and obtain debt finance, each generation is less risk averse than the preceding one. However, increasing family conflict over successive generations instigates economic value-destroying behavior. Overall, our findings suggest that economic value creation, leverage and international diversification in FFs will be conditioned not only by the ownership structure and size of the company, but also by the firm's current point in the business life cycle, the generation that is in charge, and activism from other family members, all of which play a decisive role in the FF internationalization and economic value creation process

Prevention and management of secondary central nervous system lymphoma

Prevention; LymphomaPrevenció; LimfomaPrevención; LinfomaSecondary central nervous system (CNS) lymphoma (SCNSL) is defined by the involvement of the CNS, either at the time of initial diagnosis of systemic lymphoma or in the setting of relapse, and can be either isolated or with synchronous systemic disease. The risk of CNS involvement in patients with diffuse large B-cell lymphoma is approximately 5%; however, certain clinical and biological features have been associated with a risk of up to 15%. There has been growing interest in improving the definition of patients at increased risk of CNS relapse, as well as identifying effective prophylactic strategies to prevent it. SCNSL often occurs within months of the initial diagnosis of lymphoma, suggesting the presence of occult disease at diagnosis in many cases. The differing presentations of SCNSL create the therapeutic challenge of controlling both the systemic disease and the CNS disease, which uniquely requires agents that penetrate the blood-brain barrier. Outcomes are generally poor with a median overall survival of approximately 6 months in retrospective series, particularly in those patients presenting with SCNSL after prior therapy. Prospective studies of intensive chemotherapy regimens containing high-dose methotrexate, followed by hematopoietic stem cell transplantation have shown the most favorable outcomes, especially for patients receiving thiotepa-based conditioning regimens. However, a proportion of patients will not respond to induction therapies or will subsequently relapse, indicating the need for more effective treatment strategies. In this review we focus on the identification of high-risk patients, prophylactic strategies and recent treatment approaches for SCNSL. The incorporation of novel agents in immunochemotherapy deserves further study in prospective trials

Core reduction practices at Punta de la Peña (Antofagasta de la Sierra, Catamarca): an analysis of the different ways of working stones at procurement contexts

Los sitios cantera presentan un registro lítico diverso que se vincula con distintos procedimientos técnicos empleados por las personas para extraer materias primas necesarias para la subsistencia. El presente estudio tuvo por objeto analizar la diversidad de procedimientos y prácticas empleadas por los/as talladores/as para efectuar la reducción de núcleos en canteras. Para ello, se efectuaron prospecciones sistemáticas, muestreos y un análisis técnico-tipológico de conjuntos de núcleos de dos canteras de vulcanitas (PPZAC y POZAC), situadas en la localidad de Punta de la Peña (Antofagasta de la Sierra, Catamarca). Como parte de este estudio se registraron distintos grupos de núcleos (de lascados aislados, poliédricos, bifaciales, nucleiformes, entre otros) que presentan técnicas de talla particulares, entre ellas: talla simple, bifacial, multifacial y centrípeta; además de núcleos que poseen tratamientos específicos de las plataformas de percusión y de los frentes de extracción. A partir de esta investigación se registraron prácticas individuales o colectivas y los “modos de hacer específicos” que se llevaron a cabo en los sistemas tecnológicos vinculados al aprovisionamiento lítico en canteras de vulcanitas.Quarry sites present a variable lithic record that is linked to the different technical procedures used by people in extracting the necessary raw materials for subsistence. The purpose of this study was to analyze the diversity of procedures and practices used by knappers for core reduction at quarries. To this end, systematic surveys, sampling, and a techno-typological analysis of cores from two quarries (PPZAC and POZAC) were carried out. We identified different core types (isolated flakes cores, polyhedral cores, bifacial cores, ake-cores, among others) that present particular knapping techniques: simple, bifacial, multifacial and centripetal. In addition, cores with specific treatment of the percussion platforms and the core face were documented. From this study, individual or collective practices and “specific ways of doing” that formed part of the technological systems linked to lithic procurement at volcanic rocks quarries were recorded

Some free boundary problems in potential flow regime usinga based level set method

Recent advances in the field of fluid mechanics with moving fronts are linked to the use of Level Set Methods, a versatile mathematical technique to follow free boundaries which undergo topological changes. A challenging class of problems in this context are those related to the solution of a partial differential equation posed on a moving domain, in which the boundary condition for the PDE solver has to be obtained from a partial differential equation defined on the front. This is the case of potential flow models with moving boundaries. Moreover the fluid front will possibly be carrying some material substance which will diffuse in the front and be advected by the front velocity, as for example the use of surfactants to lower surface tension. We present a Level Set based methodology to embed this partial differential equations defined on the front in a complete Eulerian framework, fully avoiding the tracking of fluid particles and its known limitations. To show the advantages of this approach in the field of Fluid Mechanics we present in this work one particular application: the numerical approximation of a potential flow model to simulate the evolution and breaking of a solitary wave propagating over a slopping bottom and compare the level set based algorithm with previous front tracking models

From fuzzy to annotated semantic web languages

The aim of this chapter is to present a detailed, selfcontained and comprehensive account of the state of the art in representing and reasoning with fuzzy knowledge in Semantic Web Languages such as triple languages RDF/RDFS, conceptual languages of the OWL 2 family and rule languages. We further show how one may generalise them to so-called annotation domains, that cover also e.g. temporal and provenance extensions

Comparative effectiveness of ZUMA-5 (axi-cel) vs SCHOLAR-5 external control in relapsed/refractory follicular lymphoma

Follicular lymphomaLimfoma fol·licularLinfoma folicularIn the pivotal ZUMA-5 trial, axicabtagene ciloleucel (axi-cel; an autologous anti-CD19 chimeric antigen receptor T-cell therapy) demonstrated high rates of durable response in relapsed/refractory (r/r) follicular lymphoma (FL) patients. Here, outcomes from ZUMA-5 are compared with the international SCHOLAR-5 cohort, which applied key ZUMA-5 trial eligibility criteria simulating randomized controlled trial conditions. SCHOLAR-5 data were extracted from institutions in 5 countries, and from 1 historical clinical trial, for r/r FL patients who initiated a third or higher line of therapy after July 2014. Patient characteristics were balanced through propensity scoring on prespecified prognostic factors using standardized mortality ratio (SMR) weighting. Time-to-event outcomes were evaluated using weighted Kaplan-Meier analysis. Overall response rate (ORR) and complete response (CR) rate were compared using weighted odds ratios. The 143 ScHOLAR-5 patients reduced to an effective sample of 85 patients after SMR weighting vs 86 patients in ZUMA-5. Median follow-up time was 25.4 and 23.3 months for SCHOLAR-5 and ZUMA-5. Median overall survival (OS) and progression-free survival (PFS) in SCHOLAR-5 were 59.8 months and 12.7 months and not reached in ZUMA-5. Hazard ratios for OS and PFS were 0.42 (95% confidence interval [CI], 0.21-0.83) and 0.30 (95% CI, 0.18-0.49). The ORR and CR rate were 49.9% and 29.9% in SCHOLAR-5 and 94.2% and 79.1% in ZUMA-5, for odds ratios of 16.2 (95% CI, 5.6-46.9) and 8.9 (95% CI, 4.3-18.3). Compared with available therapies, axi-cel demonstrated an improvement in meaningful clinical endpoints, suggesting axi-cel addresses an important unmet need for r/r FL patients. This trial was registered at www.clinicaltrials.gov as #NCT03105336.Was provided by Kite Pharma, a Gilead company, for this study

A 24-month updated analysis of the comparative effectiveness of ZUMA-5 (axi-cel) vs. SCHOLAR-5 external control in relapsed/refractory follicular lymphoma

Follicular lymphoma; Axicabtagene ciloleucel; Comparative effectivenessLimfoma fol·licular; Axicabtagene ciloleucel; Eficàcia comparativaLinfoma folicular; Axicabtagene ciloleucel; Eficacia comparativaBackground In the ZUMA-5 trial (Clinical trials identification: NCT03105336), axicabtagene ciloleucel (axi-cel; a chimeric antigen receptor T-cell therapy) demonstrated high rates of durable response in relapsed/refractory (r/r) follicular lymphoma (FL) patients and clear superiority relative to the SCHOLAR-5 external control cohort. We update this comparison using the ZUMA-5 24-month data. Research design and methods The SCHOLAR-5 cohort is comprised of r/r FL patients who initiated ≥3rd line of therapy after July 2014 and meeting ZUMA-5 eligibility criteria. Groups were balanced for patient characteristics through propensity scoring on prespecified prognostic factors using standardized mortality ratio (SMR) weighting. The overall response rate was compared using a weighted logistic regression. Time-to-event outcomes were evaluated using a Cox regression. Results For SCHOLAR-5, the sum of weights for the 143 patients was 85 after SMR weighting, versus 86 patients in ZUMA-5. The median follow-up was 29.4 months and 25.4 months for ZUMA-5 and SCHOLAR-5, respectively. The hazard ratios for overall survival and progression-free survival were 0.52 (95% confidence interval (CI): 0.28–0.95) and 0.28 (95% CI: 0.17–0.45), favoring axi-cel. Conclusion This updated analysis, using a longer minimum follow-up than a previously published analysis, shows that the improved efficacy of axi-cel, relative to available therapies, in r/r FL is durable.This manuscript was funded by Kite, a Gilead Company

Minimalistic fuzzy ontology reasoning: An application to Building Information Modeling

This paper presents a minimalistic reasoning algorithm to solve imprecise instance retrieval in fuzzy ontologies with application to querying Building Information Models (BIMs)—a knowledge representation formalism used in the construction industry. Our proposal is based on a novel lossless reduction of fuzzy to crisp reasoning tasks, which can be processed by any Description Logics reasoner. We implemented the minimalistic reasoning algorithm and performed an empirical evaluation of its performance in several tasks: interoperation with classical reasoners (Hermit and TrOWL), initialization time (comparing TrOWL and a SPARQL engine), and use of different data structures (hash tables, databases, and programming interfaces). We show that our software can efficiently solve very expressive queries not available nowadays in regular or semantic BIMs tools

Rehabilitación de pacientes con movilidad reducida usando exoesqueleto y técnicas de gamificación

Este proyecto denominado consiste en la creación de un prototipo de exoesqueleto para su utilización en personas con movilidad reducida en brazos y manos. Está enfocado en entrenar al paciente con distintos grados de ejercicios y esfuerzos para ayudar en las tareas de recuperación del movimiento y aumentar así la movilidad de estas partes del cuerpo ante mencionadas. Para realizar estas funciones, el prototipo está formado por: una exo-mano que permite mover los dedos del usuario gracias al uso de motores, un exo-brazo que cuenta con un motor en el codo que ayuda al movimiento del brazo y una aplicación software con el que el usuario interactúa con el exoesqueleto y permite el entrenamiento y recolección de datos de éste. La exo-mano es capaz de imitar los movimientos de la mano del usuario a partir de un sen- sor que mide el grado de actividad del músculo de la mano, mientras que el exo-brazo calcula el grado de curvatura en función de su posición. Los componentes hardware del prototipo se interconectan con las aplicaciones software gracias al microcontrolador conectado al puerto serie del PC. La aplicación software esta´ formado por dos juegos en los que cada uno entrena una parte diferente: un juego estilo Pong con el que el usuario entrena el movimiento del brazo y en función de su grado de movilidad, el exo-brazo se adapta para ofrecer mayor o menor ayuda, y un juego con el que entrenar el movimiento tanto del brazo como de la mano, en el que la exo-mano se adapta al grado de movilidad de la mano.This project called ExoKit consists on the creation of a prototype of exoskeleton for its use in people with reduced mobility in arms and hands. It’s focused on training the patient with different types of exercises and efforts to help in the tasks of recovery of movement and thus increase the mobility of these parts of the body mentioned above. To perform these functions, the prototype consists of: an exohand that allows the user’s fingers to move thanks to the use of motors, an exo-arm that has a motor in the elbow that helps arm movement and a software application with the one that the user interacts with the exoskeleton and allows the training and data collection of the same. The exo-hand can imitate the movements of the user’s hand from a sensor that measures the degree of activity of the hand muscle, while the exo-arm calculates the degree of curvature as a function of its position. The hardware components of the prototype are interconnected with the software applications thanks to the microcontroller connected to the serial port of the PC. The software application consists of two games in which each of them trains a different part: a Pong style game with which the user trains the movement of the arm and depending on their degree of mobility, the exo-arm is adapted to offer more or less help, and a game with which to train the movement of the arm as well as the hand, in which the exo-hand adapts to the degree of mobility of the user’s hand.Universidad de Sevilla. TEP- 108: Robótica y Tecnología de Computadore