High Resolution X-ray Spectra of the Brightest OB Stars in the Cygnus OB2 Association

The Cygnus OB2 Association contains some of the most luminous OB stars in our Galaxy, the brightest of which are also among the most luminous in X-rays. We have obtained a Chandra High Energy Transmission Grating Spectrometer (HETGS) observation centered on Cyg OB2 No. 8a, the most luminous X-ray source in the Association. Although our analysis will focus on the X-ray properties of Cyg OB2 No. 8a, we also present limited analyses of three other OB stars (Cyg OB2 Nos. 5, 9, and 12). Applying standard diagnostic techniques as used in previous studies of early-type stars, we find that the X-ray properties of Cyg OB2 No. 8a are very similar to those of other OB stars that have been observed using high-resolution X-ray spectroscopy. From analyses of the He-like ion "fir" emission lines, we derive radial distances of the He-like line emission sources and find these fir-inferred radii are consistent with their corresponding X-ray continuum optical depth unity radii. Contrary to other O-star results, the emission lines of Cyg OB2 No. 8a show a large range in line centroid shifts (roughly -800 to +250 km/s). We discuss the implications of our results in light of the fact that Cyg OB2 No. 8a is a member of a rather tight stellar cluster, and shocks could arise at interfaces with the winds of these other stars.Comment: 36 pages (including 4 tables and 12 figures). LaTeX. Submitted to Ap

Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disorders

NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Affective Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Affective Disorders, [VOL 64, ISSUE 1, (2001)] DOI:10.1016/S0165-0327(00)00215-9

An Extensive Collection of Stellar Wind X-ray Source Region Emission Line Parameters,Temperatures, Velocities, and Their Radial Distributions as Obtained from Chandra Observations of 17 OB Stars

Chandra high energy resolution observations have now been obtained from numerous non-peculiar O and early B stars. The observed X-ray emission line properties differ from pre-launch predictions, and the interpretations are still problematic. We present a straightforward analysis of a broad collection of OB stellar line profile data to search for morphological trends. X-ray line emission parameters and the spatial distributions of derived quantities are examined with respect to luminosity class. The X-ray source locations and their corresponding temperatures are extracted by using the He-like f/i line ratios and the H-like to He-like line ratios respectively. Our luminosity class study reveals line widths increasing with luminosity. Although the majority of the OB emission lines are found to be symmetric, with little central line displacement, there is evidence for small, but finite, blue-ward line-shifts that also increase with luminosity. The spatial X-ray temperature distributions indicate that the highest temperatures occur near the star and steadily decrease outward. This trend is most pronounced in the OB supergiants. For the lower density wind stars, both high and low X-ray source temperatures exist near the star. However, we find no evidence of any high temperature X-ray emission in the outer wind regions for any OB star. Since the temperature distributions are counter to basic shock model predictions, we call this the "near-star high-ion problem" for OB stars. By invoking the traditional OB stellar mass loss rates, we find a good correlation between the fir-inferred radii and their associated X-ray continuum optical depth unity radii. We conclude by presenting some possible explanations to the X-ray source problems that have been revealed by this study.Comment: Published in 2007, ApJ, 668, 456. An Erratum scheduled for publication in 2008, ApJ, 680, is included as an Appendix. The Erratum corrects some tabulated data in 5 tables and 2 figure

X-ray emitting young stars in the Orion Nebula

The Orion Nebula Cluster and the molecular cloud in its vicinity have been observed with the ACIS-I detector on board the Chandra X-ray Observatory with 23 hours exposure. We detect 1075 X-ray sources: 91% are spatially associated with known stellar members of the cluster, and 7% are newly identified deeply embedded cloud members. This provides the largest X-ray study of a pre-main sequence stellar population. We examine here the X-ray properties of Orion young stars as a function of mass. Results include: (a) the discovery of rapid variability in the O9.5 31 M_o star \theta^2A Ori, and several early B stars, inconsistent with the standard model of X-ray production in small wind shocks; (b) support for the hypothesis that intermediate-mass mid-B through A type stars do not themselves produce significant X-ray emission; (c) confirmation that low-mass G- through M-type T Tauri stars exhibit powerful flaring but typically at luminosities considerably below the `saturation' level; (d) confirmation that the presence or absence of a circumstellar disk has no discernable effect on X-ray emission; (e) evidence that T Tauri plasma temperatures are often very high with T >= 100 MK, even when luminosities are modest and flaring is not evident; and (f) detection of the largest sample of pre-main sequence very low mass objects showing high flaring levels and a decline in magnetic activity as they evolve into L- and T-type brown dwarfs.Comment: 82 pages, 16 figures, 6 tables. To appear in the Astrophysical Journal. For a version with high quality images and electronic tables, see ftp://ftp.astro.psu.edu/pub/edf/orion1

Inverse Compton Scattering as the Source of Diffuse EUV Emission in the Coma Cluster of Galaxies

We have examined the hypothesis that the majority of the diffuse EUV flux in the Coma cluster is due to inverse Compton scattering of low energy cosmic ray electrons (0.16 < epsilon < 0.31 GeV) against the 3K black-body background. We present data on the two-dimensional spatial distribution of the EUV flux and show that these data provide strong support for a non-thermal origin for the EUV flux. However, we show that this emission cannot be produced by an extrapolation to lower energies of the observed synchrotron radio emitting electrons and an additional component of low energy cosmic ray electrons is required.Comment: 11 pages, 5 figure

O VI Observations of the Onset of Convection Zones in Main-Sequence A Stars

If magnetic activity in outer stellar atmospheres is due to an interplay between rotation and subsurface convection, as is generally presumed, then one would not expect to observe indicators of activity in stars with T_eff > 8300 K. Any X-ray or ultraviolet line emission from hotter stars must be due either to a different mechanism or to an unresolved, active, binary companion. Due to their poor spatial resolution, X-ray instruments have been especially susceptible to source confusion. At wavelengths longward of 1216 Angstroms, the near ultraviolet spectra of stars hotter than this putative dividing line are dominated by photospheric continuum. We have used FUSE to obtain spectra of the subcoronal O VI emission lines, which lie at a wavelength where the photospheric continuum of the mid- and early-A stars is relatively weak. We observed 14 stars spanning a range in T_eff from 7720 to 10,000 K. Eleven of the 14 stars showed O VI emission lines, including 6 of the 8 targets with T_eff > 8300 K. At face value, this suggests that activity does not fall off with increasing temperature. However, the emission lines are narrower than expected from the projected rotational velocities of these rapidly-rotating stars, suggesting that the emission could come from unresolved late-type companions. Furthermore, the strength of the O VI emission is consistent with that expected from an unseen active K or M dwarf binary companinon, and the high x-ray to far uv luminosity ratios observed indicate that this must be the case. Our results are therefore consistent with earlier studies that have shown a rapid drop-off in activity at the radiative/convective boundary expected at T_eff about 8300 K, in agreement with conventional stellar structure models

A Chandra/ACIS Study of 30 Doradus II. X-ray Point Sources in the Massive Star Cluster R136 and Beyond

We have studied the X-ray point source population of the 30 Doradus star-forming complex in the Large Magellanic Cloud using high-spatial-resolution X-ray images and spatially-resolved spectra obtained with the Advanced CCD Imaging Spectrometer (ACIS) aboard the Chandra X-ray Observatory. Here we describe the X-ray sources in a 17' x 17' field centered on R136, the massive star cluster at the center of the main 30 Dor nebula. We detect 20 of the 32 Wolf-Rayet stars in the ACIS field. R136 is resolved at the subarcsecond level into almost 100 X-ray sources, including many typical O3--O5 stars as well as a few bright X-ray sources previously reported. Over two orders of magnitude of scatter in L_X is seen among R136 O stars, suggesting that X-ray emission in the most massive stars depends critically on the details of wind properties and binarity of each system, rather than reflecting the widely-reported characteristic value L_X/L_bol ~ 10^{-7}. Such a canonical ratio may exist for single massive stars in R136, but our data are too shallow to confirm this relationship. Through this and future X-ray studies of 30 Doradus, the complete life cycle of a massive stellar cluster can be revealed.Comment: 31 pages, 6 bitmapped figures, 5 tables; accepted to A

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy.

Background Recently, inflammatory cascades have been suggested as a target for epilepsy therapy. Positron emission tomography (PET) imaging offers the unique possibility to evaluate brain inflammation longitudinally in a non-invasive translational manner. This study investigated brain inflammation during early epileptogenesis in the post-kainic acid-induced status epilepticus (KASE) model with post-mortem histology and in vivo with [18F]-PBR111 PET. Methods Status epilepticus (SE) was induced (N = 13) by low-dose injections of KA, while controls (N = 9) received saline. Translocator protein (TSPO) expression and microglia activation were assessed with [125I]-CLINDE autoradiography and OX-42 immunohistochemistry, respectively, 7 days post-SE. In a subgroup of rats, [18F]-PBR111 PET imaging with metabolite-corrected input function was performed before post-mortem evaluation. [18F]-PBR111 volume of distribution (V t) in volume of interests (VOIs) was quantified by means of kinetic modelling and a VOI/metabolite-corrected plasma activity ratio. Results Animals with substantial SE showed huge overexpression of TSPO in vitro in relevant brain regions such as the hippocampus and amygdala (P < 0.001), while animals with mild symptoms displayed a smaller increase in TSPO in amygdala only (P < 0.001). TSPO expression was associated with OX-42 signal but without obvious cell loss. Similar in vivo [18F]-PBR111 increases in V t and the simplified ratio were found in key regions such as the hippocampus (P < 0.05) and amygdala (P < 0.01). Conclusion Both post-mortem and in vivo methods substantiate that the brain regions important in seizure generation display significant brain inflammation during epileptogenesis in the KASE model. This work enables future longitudinal investigation of the role of brain inflammation during epileptogenesis and evaluation of anti-inflammatory treatments. © 2012, Springer

High-Resolution Chandra X-Ray Imaging And Spectroscopy Of The Sigma Orionis Cluster

We present results of a 90 ks Chandra X-ray observation of the young sigma Orionis cluster ( age similar to 3 Myr) obtained with the HETGS. We use the high-resolution grating spectrum and moderate-resolution CCD spectrum of the massive central star sigma Ori AB (O9.5 V + B0.5 V) to test wind shock theories of X-ray emission and also analyze the high spatial resolution zero-order ACIS-S image of the central cluster region. Chandra detected 42 X-ray sources on the primary CCD (ACIS-S3). All but five have near-IR or optical counterparts and about one-fourth are variable. Notable high-mass stellar detections are sigma Ori AB, the magnetic B star sigma Ori E, and the B5 V binary HD 37525. Most of the other detections have properties consistent with lower mass K- or M-type stars. We present the first X-ray spectrum of the unusual infrared source IRS 1, located approximate to 3 \u27\u27 north of sigma Ori AB. Its X-ray properties and elongated mid-IR morphology suggest that it is an embedded low-mass T Tauri star whose disk/envelope is being photoevaporated by sigma Ori AB. We focus on the radiative wind shock interpretation of the soft luminous X-ray emission from sigma Ori AB, but also consider possible alternatives including magnetically confined wind shocks and colliding wind shocks. Its emission lines show no significant asymmetries or centroid shifts and are moderately broadened to HWHM approximate to 264 km s(-1), or one-fourth the terminal wind speed. Forbidden lines in He-like ions are formally undetected, implying strong UV suppression. The Mg XI triplet forms in the wind acceleration zone within one stellar radius above the surface. These X-ray properties are consistent in several respects with the predictions of radiative wind shock theory for an optically thin wind, but explaining the narrow line widths presents a challenge to the theory

X-ray Observations of the New Pulsar--Supernova Remnant System PSR J1119-6127 and SNR G292.2-0.5

PSR J1119-6127 is a recently discovered 1700-year-old radio pulsar that has a very high inferred surface dipolar magnetic field. We present a detailed analysis of a pointed ASCA observation and archival ROSAT data of J1119-6127 and its surroundings. Both data sets reveal extended emission coincident with the newly-discovered radio supernova remnant G292.2-0.5, reported in a companion paper by Crawford et al. (astro-ph/0012287).. A hard point source, offset ~1.5' from the position of the radio pulsar, is seen with the ASCA GIS. No pulsations are detected at the radio period with a pulsed fraction upper limit of 61% (95% confidence). The limited statistics prevent a detailed spectral analysis, although a power-law model with photon index (Gamma=~1-2) describes the data well. Both the spectral model and derived X-ray luminosity are consistent with those measured for other young radio pulsars, although the spatial offset renders an identification of the source as the X-ray counterpart of the pulsar uncertain.Comment: Accepted by ApJ; 12 Pages in emulated ApJ format with embedded tables and color figure