1,218 research outputs found
Chaos properties and localization in Lorentz lattice gases
The thermodynamic formalism of Ruelle, Sinai, and Bowen, in which chaotic
properties of dynamical systems are expressed in terms of a free energy-type
function - called the topological pressure - is applied to a Lorentz Lattice
Gas, as typical for diffusive systems with static disorder. In the limit of
large system sizes, the mechanism and effects of localization on large clusters
of scatterers in the calculation of the topological pressure are elucidated and
supported by strong numerical evidence. Moreover it clarifies and illustrates a
previous theoretical analysis [Appert et al. J. Stat. Phys. 87,
chao-dyn/9607019] of this localization phenomenon.Comment: 32 pages, 19 Postscript figures, submitted to PR
Bidirectional transport on a dynamic lattice
Bidirectional variants of stochastic many particle models for transport by
molecular motors show a strong tendency to form macroscopic clusters on static
lattices. Inspired by the fact that the microscopic tracks for molecular motors
are dynamical, we study the influence of different types of lattice dynamics on
stochastic bidirectional transport. We observe a transition toward efficient
transport (corresponding to the dissolution of large clusters) controlled by
the lattice dynamics.Comment: 5 pages, 5 figure
Neuroprotective Effects of (-)-Epigallocatechin 3-O-gallate (EGCG) on l-methyl-4- phenyl-l,2,3,6-tetrahydropyridine (MPTP) and Hydrogen Peroxide (H2O2) Stressed PC 12 Cells
Despite the fact that Parkinson’s disease (PD) is the second most common neurodegenerative disease, much of its etiology and pathogenesis remains to be discovered. The main pathological feature of PD is the progressive death of specific dopaminergic (DAergic) neurons in the brain. Oxidative stress induced cell death has been hypothesized as one mechanism responsible for PD pathogenesis.
Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) that has been implicated in PD as a by-product of dopamine (DA) degradation. 1 -methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) has been shown to produce a Parkinsonian syndrome via an oxidative stress induced mechanism. For these reasons, H2O2 and MPTP were used in this study to treat DAergic PC 12 cells to produce a model of PD.
We hypothesized that (-)-epigallocatechin 3-O-gallate (EGCG), a principal chemical component of green tea known for a plethora of health promoting bioactive properties, protects PC 12 cells from H2O2- and MPTP-induced stress.
PC 12 cells treated with EGCG showed increased cell count when compared to untreated cells or cells only treated with H2O2 or MPTP. Cell count increased as EGCG concentration increased.
The results of this study demonstrate that EGCG has neuroprotective effects on H2O2 and MPTP stressed PC 12 cells
Particle interactions and lattice dynamics: Scenarios for efficient bidirectional stochastic transport?
Intracellular transport processes driven by molecular motors can be described
by stochastic lattice models of self-driven particles. Here we focus on
bidirectional transport models excluding the exchange of particles on the same
track. We explore the possibility to have efficient transport in these systems.
One possibility would be to have appropriate interactions between the various
motors' species, so as to form lanes. However, we show that the lane formation
mechanism based on modified attachment/detachment rates as it was proposed
previously is not necessarily connected to an efficient transport state and is
suppressed when the diffusivity of unbound particles is finite. We propose
another interaction mechanism based on obstacle avoidance that allows to have
lane formation for limited diffusion. Besides, we had shown in a separate paper
that the dynamics of the lattice itself could be a key ingredient for the
efficiency of bidirectional transport. Here we show that lattice dynamics and
interactions can both contribute in a cooperative way to the efficiency of
transport. In particular, lattice dynamics can decrease the interaction
threshold beyond which lanes form. Lattice dynamics may also enhance the
transport capacity of the system even when lane formation is suppressed.Comment: 25 pages, 17 figures, 2 table
Frozen shuffle update for an asymmetric exclusion process on a ring
We introduce a new rule of motion for a totally asymmetric exclusion process
(TASEP) representing pedestrian traffic on a lattice. Its characteristic
feature is that the positions of the pedestrians, modeled as hard-core
particles, are updated in a fixed predefined order, determined by a phase
attached to each of them. We investigate this model analytically and by Monte
Carlo simulation on a one-dimensional lattice with periodic boundary
conditions. At a critical value of the particle density a transition occurs
from a phase with `free flow' to one with `jammed flow'. We are able to
analytically predict the current-density diagram for the infinite system and to
find the scaling function that describes the finite size rounding at the
transition point.Comment: 16 page
Intersection of two TASEP traffic lanes with frozen shuffle update
Motivated by interest in pedestrian traffic we study two lanes
(one-dimensional lattices) of length that intersect at a single site. Each
lane is modeled by a TASEP (Totally Asymmetric Exclusion Process). The
particles enter and leave lane (where ) with probabilities
and , respectively. We employ the `frozen
shuffle' update introduced in earlier work [C. Appert-Rolland et al, J. Stat.
Mech. (2011) P07009], in which the particle positions are updated in a fixed
random order. We find analytically that each lane may be in a `free flow' or in
a `jammed' state. Hence the phase diagram in the domain
consists of four regions with boundaries
depending on and . The regions meet in a single point on the
diagonal of the domain. Our analytical predictions for the phase boundaries as
well as for the currents and densities in each phase are confirmed by Monte
Carlo simulations.Comment: 7 figure
Spontaneous symmetry breaking in a two-lane model for bidirectional overtaking traffic
First we consider a unidirectional flux \omega_bar of vehicles each of which
is characterized by its `natural' velocity v drawn from a distribution P(v).
The traffic flow is modeled as a collection of straight `world lines' in the
time-space plane, with overtaking events represented by a fixed queuing time
tau imposed on the overtaking vehicle. This geometrical model exhibits platoon
formation and allows, among many other things, for the calculation of the
effective average velocity w=\phi(v) of a vehicle of natural velocity v.
Secondly, we extend the model to two opposite lanes, A and B. We argue that the
queuing time \tau in one lane is determined by the traffic density in the
opposite lane. On the basis of reasonable additional assumptions we establish a
set of equations that couple the two lanes and can be solved numerically. It
appears that above a critical value \omega_bar_c of the control parameter
\omega_bar the symmetry between the lanes is spontaneously broken: there is a
slow lane where long platoons form behind the slowest vehicles, and a fast lane
where overtaking is easy due to the wide spacing between the platoons in the
opposite direction. A variant of the model is studied in which the spatial
vehicle density \rho_bar rather than the flux \omega_bar is the control
parameter. Unequal fluxes \omega_bar_A and \omega_bar_B in the two lanes are
also considered. The symmetry breaking phenomenon exhibited by this model, even
though no doubt hard to observe in pure form in real-life traffic, nevertheless
indicates a tendency of such traffic.Comment: 50 pages, 16 figures; extra references adde
Lattice gas with ``interaction potential''
We present an extension of a simple automaton model to incorporate non-local
interactions extending over a spatial range in lattice gases. {}From the
viewpoint of Statistical Mechanics, the lattice gas with interaction range may
serve as a prototype for non-ideal gas behavior. {}From the density
fluctuations correlation function, we obtain a quantity which is identified as
a potential of mean force. Equilibrium and transport properties are computed
theoretically and by numerical simulations to establish the validity of the
model at macroscopic scale.Comment: 12 pages LaTeX, figures available on demand ([email protected]
Chaotic properties of systems with Markov dynamics
We present a general approach for computing the dynamic partition function of
a continuous-time Markov process. The Ruelle topological pressure is identified
with the large deviation function of a physical observable. We construct for
the first time a corresponding finite Kolmogorov-Sinai entropy for these
processes. Then, as an example, the latter is computed for a symmetric
exclusion process. We further present the first exact calculation of the
topological pressure for an N-body stochastic interacting system, namely an
infinite-range Ising model endowed with spin-flip dynamics. Expressions for the
Kolmogorov-Sinai and the topological entropies follow.Comment: 4 pages, to appear in the Physical Review Letter
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