Chemical studies of marine invertebrates. XLI. Sigmosceptrellin-A methyl ester a nor-sesterterpenoid peroxide from the sponge sigmosceptrella laevis.

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Hodgkin's disease in 50 intravenous drug users with HIV-infection

Fifty cases of Hodgkin's diseases in intravenous drug users (IVDU) have been collected by the Italian Cooperative Group on AIDS-related tumors (GICAT). in conclusion, Hodgkin's disease in IVDU was not found to be associated with unusual presentations, as previously reported in homosexuals. Complete remission could be achieved in over 50% of patients, but in IVDU non-opportunistic infections in addition to opportunistic infections may also limit treatment administration. The presence of parenchymal functional impairment due to drug use, or drug abuse-related infections, such as pneumonia, endocarditis and hepatitis, should lead to the choice of antitumors agents with no or only minor potential liver, lung and cardiac toxicity

Cyclic peroxides and related norterpenes from a southern Australian marine sponge, Mycale sp.

Investigation of a southern Australian marine sponge, Mycale sp., resulted in isolation of the known norsesterterpenes 1-3 as well as two new isomeric norsesterterpenes, mycaperoxide C methyl ester (4) and mycaperoxide D methyl ester (5), and six new norterpenes (6-11)

In vitro pharmacological and toxicological effects of norterpene peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells.

Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC₅₀ growth inhibitory concentrations in vitro of <10 μM, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe