Room-temperature multicomponent synthesis of 3,4-dihydroquinoxalin-2-amine derivatives using highly ordered 3D nanoporous aluminosilicate catalyst

Here we demonstrate on the synthesis of multifunctional 3,4-dihydroquinoxalin-2-amine derivatives through a three-component condensation of substituted o-phenylenediamines (OPDA), diverse ketones, and various isocyanides in the presence of AlKIT-5 catalyst which was found to be highly active and selective, affording excellent yields (85-98%) in ethanol at room temperature (2-4 h)

Synthesis of triazolo indazolones using 3D mesoporous aluminosilicate catalyst with nanocage structure

Mesoporous Aluminosilicate (AlKIT-5) has been found to be an efficient catalyst for one-pot synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives from dimedone, urazole, and aromatic aldehydes using acetonitrile as a solvent. This new method is simple, effective, ecofriendly, and consistently has the advantage of excellent yields (80–96%) and short reaction time (30–60 min). The effect of the catalyst weight, aluminum content in the catalyst, and the solvents on the synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives has been investigated. It has been found that the catalyst can be recycled for several times without much affecting its activity for a variety of organic transformations

ZnO-loaded mesoporous silica (KIT-6) as an efficient solid catalyst for production of various substituted quinoxalines

Conventional homogeneous and microporous heterogeneous catalysts for quinoxalines production from diamines and diketones usually suffer from difficult separation or harsh reaction conditions. Here, we demonstrate the production of various substituted quinoxalines using ZnO nanoparticle-loaded, highly ordered, mesoporous silica KIT-6 materials as solid catalysts in room temperature. The results show that the KIT-6-130-10Zn sample (aged at 130 °C and containing 10 wt% ZnO) effectively produces quinoxalines up to the maximum of 99%. We propose that the enhanced performance of the ZnO-loaded KIT-6 materials resulted from the homogeneous distribution of ZnO nanoparticles, along with the KIT-6\u27s high specific surface area and large pore sizes