226 research outputs found

    Discussion of Recent Decisions

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    Notes by E. Kucaba, J. B. Wyatt Jr., H. H. Flentye, J. Safeblade, B. Daidone, J. E. Jacobs, W. Heind

    Estimating the costs of specialised care

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    In most sectors of the economy, specialisation is associated with lower costs. Yet some specialised hospitals claim to require more generous funding than general hospitals. This claim is based on the assertion that their patients are different, and that these differences outweigh the cost advantages of specialisation. Unless the basis for this claim can be established, the financial incentives introduced by Payment by Results to encourage cost reducing behaviour will be diluted.

    Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

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    <p>Abstract</p> <p>Background</p> <p>Most cancers maintain telomeres by activating telomerase but a significant minority, mainly of mesenchymal origin, utilize an alternative lengthening of telomeres (ALT) mechanism.</p> <p>Methods</p> <p>In this study we comparatively analyzed the prognostic relevance of ALT in a monoinstitutional series of 85 liposarcoma patients as a function of the marker (ALT-associated promyelocytic leukemia bodies (APB) versus heterogeneous telomeres) used to classify the tumor.</p> <p>Results</p> <p>Independently of the detection approach, ALT proved to be a prognostic discriminant of increased mortality, although the prognostic relevance of the two markers appeared at different follow-up intervals (at 10 years for APB and 15 years for telomeres).</p> <p>Conclusions</p> <p>Overall, we confirmed ALT as an indicator of poor clinical outcome in this disease and provide the first evidence that the sensitivity of the ALT predictive power depends, at least in part, on the method used.</p

    Il centro civico polivalente di Modica, Arch. Emanuele Fidone, 2005-2009. Gli ambiti spaziali di un centro sociale in un terreno acclive

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    Santo Giunta ritorna a scrivere sul centro civico polivalente di Modica di Emanuele Fidone dopo l’articolo per Domus (n. 929/2009). Il centro civico, che ha ottenuto importanti riconoscimenti, come la menzione speciale alla Medaglia d’oro di Architettura Italiana alla Triennale di Milano (2009), è un’architettura volutamente “piena”, che sembra levitare sul suolo. Il progetto disciplina, non solo funzionalmente, un accurato sistema di percorsi, che guarda sia alle relazioni che la fabbrica intesse al contorno, sia alla peculiare situazione orografica del sito. È una successione percettiva di spazi – il lungo corpo dei servizi, l’alta galleria a doppia altezza e la sala polivalente – che costituisce un’alta quinta e racchiude quello che una volta era lo slargo-parcheggio del nuovo Tribunale

    Meningkatkan Kemampuan Berbicara Siswa Kelas XI PM 1 dengan Strategi Pembelajaran Berdiferensiasi

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    It is common knowledge that graduates of vocational schools (SMK) are oriented toward the working world. Undoubtedly, English is highly essential to support the competence of these graduates. However, regrettably, English remains a daunting challenge, especially when it comes to speaking skills. Therefore, differentiated learning is of great importance to be implemented. Differentiated learning is a teaching strategy oriented toward the learning needs of students. In this research, the researcher employed differentiated learning, focusing on differentiating content, processes, and environments, with reference to addressing various learning styles. The aim of this research was to enhance the speaking skills of the 11th-grade PM 1 class using differentiated learning. The study utilized the Class Action Research (CAR) method, consisting of two cycles. Each cycle encompassed four stages: planning, acting, observing, and reflecting. Collaborative action research was conducted, involving the collaboration of the researcher and an English teacher serving as a mentor. Data collection involved tests, observations, and presentation assessments. The data analysis employed quantitative descriptive analysis, which presented the results in a descriptive form for quantitative data. Based on the research conducted, it was found that students' speaking skills were very low. In the pretest stage, their average score was 60. In the first cycle, there was an improvement to 70, and in the second cycle, there was a further increase to 85. From these results, it can be concluded that the use of differentiated learning is highly effective in improving the speaking skills of SMK Negeri 1 Banyuwangi 11th-grade PM 1 students

    Sprawozdanie z XXVIII Konferencji Naukowej European Cell Proliferation Society

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    Inside AICPA, July 19, 1993

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    https://egrove.olemiss.edu/aicpa_news/4250/thumbnail.jp
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