Emotionally Charged Aesthetic Experience

Abstract In traditional aesthetics, the typical characteristic of aesthetic experience is said to be pure disinterested beauty. However, the discussion based on this notion is burdened with the philosophical background assumptions of German idealism. In his Art as Experience John Dewey challenged the classical philosophical tradition and presented the key ideas for developing a new concept of aesthetic experience. In order to understand his pragmatist notion of aesthetic experience it is necessary to discuss a number of topics concerning pragmatist the challenge to classical philosophy. The philosophical naturalism of pragmatism questions the traditional distinction between the changing empirical world and the mind-independent real world as an object of genuine knowledge. There is only one world and we are in it. Dewey’s naturalism is, however, in important respects different from the main trend in contemporary naturalism. Further, the pragmatist conception of experience must be clearly distinguished from the traditional notion of experience as sense experience. Action and practice are modes of experiencing and understanding the world. The third topic concerns the naturalistic denial of any immaterial substances. The mind is necessarily embodied, but this is not enough to remove the classical dichotomy between internal and external. A fourth questionable dichotomy in classical philosophy is related to this: the sharp distinction between reason and experience. The pragmatist notion of meaning undermines this dualism. This notion of meaning also serves as a basis for understanding Dewey’s comments on the meanings typical in art. Finally, the emotionally expressive power of art requires an explanation. A discussion of all these points helps to clarify the character of the pragmatist notion of aesthetic experience developed below.Peer reviewe

Two middle-aged women with the Finnish variant of muscle-eye-brain disease (MEB)

Muscle-eye-brain disease (MEB) is a recessively inherited rare disease. Sixteen different gene mutations are known, with the most common mutations in the POMGNT1 gene. The disease is now called congenital muscular dystrophy-dystroglycanopathy type A3 (MDDGA3). It manifests itself as muscular dystrophy with eye and brain anomalies and intellectual disability. Previous clinical reports describe young patients. We have been able to follow two patients for almost 40 years. Their clinical picture has remained quite stable since adolescence, appearing as severe intellectual and motor disability, extremely limited communication skills, visual impairment, epilepsy, joint contractures, repeated bowel obstructions, teeth abrasion due to bruxism, an irregular sleep pattern and as a previously unreported feature hypothermic periods manifesting as excessive sleepiness

The Exomars Climate Sounder (EMCS) Investigation

The ExoMars Climate Sounder (EMCS) investigation is developed at the Jet Propulsion Laboratory (Principal Investigator J. T. Schofield) in collaboration with an international scientific team from France, the United Kingdom and the USA. EMCS plans to map daily, global, pole-to-pole profiles of temperature, dust, water and CO2 ices, and water vapor from the proposed 2016 ExoMars Trace Gas Orbiter (EMTGO). These profiles are to be assimilated into Mars General Circulation Models (MGCMs) to generate global, interpolated fields of measured and derived parameters such as wind

Prostate cancer risk among users of digoxin and other antiarrhythmic drugs in the Finnish Prostate Cancer Screening Trial

Peer reviewe

Is Symptomatic Long QT Syndrome Associated with Depression in Women and Men?

We examined whether long QT syndrome (LQTS) mutation carrier status or symptomatic LQTS are associated with depression, and whether there are sex differences in these potential relationships. The sample comprised 782 participants (252 men). Of the 369 genetically defined LQTS mutation carriers, 169 were symptomatic and 200 were asymptomatic. The control group consisted of 413 unaffected relatives. Depression was assessed using the Beck Depression Inventory-II (BDI-II). No association was found for LQTS mutation carrier status with depression. The multinomial logistic regression showed that LQTS mutation carrier men with arrhythmic events scored higher on depression compared with the control group, even when adjusting for age, beta-blockers, antidepressants, and social support (OR = 1.09, 95 % CI [1.02, 1.15], p = .007). The binary logistic regression comparing symptomatic and asymptomatic LQTS mutation carriers showed that symptomatic LQTS was associated with depression in men (OR = 1.10, 95 % CI [1.03, 1.19], p = .009). The results were unchanged when additionally adjusted for education. These findings suggest that symptomatic LQTS is associated with depression in men but not in women. Overall, however, depression is more frequent in women than men. Thus, regular screening for depression in LQTS mutation carriers and their unaffected family members can be important.Peer reviewe

Troposphere-to-mesosphere microphysics of carbon dioxide ice clouds in a Mars Global Climate Model

We have implemented full CO ice cloud microphysics into the LMD Mars Global Climate Model (MGCM) and we have conducted the first global simulations. The microphysical model implementation follows the modal scheme used for water ice cloud microphysics in the MGCM, but includes specific aspects that need to be accounted for when dealing with CO ice clouds. These include nucleation of CO on water ice crystals and CO condensation theory adapted for the Martian conditions. The model results are compared to available observations globally, and separately for polar regions and equatorial mesosphere. The observed seasonal and latitudinal variability of the CO ice clouds is in general reproduced. The polar regions are covered by CO ice clouds during the winter as observed. Instead of forming only in the lowest 10–15 km of the atmosphere, they extend up to several tens of kilometers above the surface in the model, dictated by the modeled temperature structure. We have also quantified the contribution of the cloud microphysics to the surface CO ice deposits. Snowfall from these clouds contributes up to 10% of the atmosphere–surface ice flux in the polar regions in our simulations, in the range that has been indirectly deduced from observations. In the mesosphere, notable amounts of CO ice clouds form only when water ice crystals are used as condensation nuclei in addition to dust particles, and their spatial distribution is in agreement with observations. The mesospheric temperature structure, dominated by tides, dictates the longitudinal and seasonal distribution of these clouds. The seasonal and local time variations of the clouds are not fully reproduced by the model. There is a long pause in CO ice cloud formation in the model around the aphelion season, but clouds have been observed during this period, although with a lower apparition frequency. Modeled mesospheric clouds form mainly during the night and in the morning, whereas during the daytime, when most of the cloud observations have been made, the model rarely predicts clouds. These discrepancies could be explained by the strong dependence of the cloud formation process on mesospheric temperatures that are themselves challenging to reproduce and sensitive to the MGCM processes and parameters. The rare possibilities for nighttime observations might also bias the observational climatologies towards daytime detections. Future developments of the model consist in the inclusion of a possible exogenous condensation nucleus source in the mesosphere and the radiative effect of CO ice clouds. © 2022 Elsevier Inc. All rights reserved.This paper presents the results of ten years of development that has been supported by funding from several sources. We thank the Agence National de la Recherche for funding (project MECCOM, ANR-18-CE31-0013). We are also grateful for the financial support by the LabEx (Laboratoire d’Excellence) ESEP, by the French space agency CNES and the European Space Agency ESA. We acknowledge the support of the French national planetology programme (PNP) as well. F.G.-G. is funded by the Spanish Ministerio de Ciencia, Innovación y Universidades, the Agencia Estatal de Investigación and EC FEDER funds under project RTI2018-100920-J-I00, and acknowledges financial support from the State Agency for Research of the Spanish MCIU through the Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). This work was performed using HPC computing resources from GENCI-CINES (Grant 2021-A0100110391), and resources at the ESPRI mesocentre of the IPSL institute .Peer reviewe

The Atmospheric Chemistry Suite (ACS) of Three Spectrometers for the ExoMars 2016 Trace Gas Orbiter

The Atmospheric Chemistry Suite (ACS) package is an element of the Russian contribution to the ESA-Roscosmos ExoMars 2016 Trace Gas Orbiter (TGO) mission. ACS consists of three separate infrared spectrometers, sharing common mechanical, electrical, and thermal interfaces. This ensemble of spectrometers has been designed and developed in response to the Trace Gas Orbiter mission objectives that specifically address the requirement of high sensitivity instruments to enable the unambiguous detection of trace gases of potential geophysical or biological interest. For this reason, ACS embarks a set of instruments achieving simultaneously very high accuracy (ppt level), very high resolving power (>10,000) and large spectral coverage (0.7 to 17 μm—the visible to thermal infrared range). The near-infrared (NIR) channel is a versatile spectrometer covering the 0.7–1.6 μm spectral range with a resolving power of ∼20,000. NIR employs the combination of an echelle grating with an AOTF (Acousto-Optical Tunable Filter) as diffraction order selector. This channel will be mainly operated in solar occultation and nadir, and can also perform limb observations. The scientific goals of NIR are the measurements of water vapor, aerosols, and dayside or night side airglows. The mid-infrared (MIR) channel is a cross-dispersion echelle instrument dedicated to solar occultation measurements in the 2.2–4.4 μm range. MIR achieves a resolving power of >50,000. It has been designed to accomplish the most sensitive measurements ever of the trace gases present in the Martian atmosphere. The thermal-infrared channel (TIRVIM) is a 2-inch double pendulum Fourier-transform spectrometer encompassing the spectral range of 1.7–17 μm with apodized resolution varying from 0.2 to 1.3 cm−1. TIRVIM is primarily dedicated to profiling temperature from the surface up to ∼60 km and to monitor aerosol abundance in nadir. TIRVIM also has a limb and solar occultation capability. The technical concept of the instrument, its accommodation on the spacecraft, the optical designs as well as some of the calibrations, and the expected performances for its three channels are described