7 research outputs found
Los registros acumulativos de casos psiquiátricos como sistema de información y evaluación dentro del marco de la reforma psiquiátrica. Documento del grupo de trabajo sobre registros de casos psiquiátricos.
- Author
- Publication venue
- Asociación Española de Neuropsiquiatría
- Publication date
- 01/01/1992
- Field of study
Sin resumen
Los registros acumulativos de casos psiquiátricos como sistema de información y evaluación dentro del marco de la reforma psiquiátrica. Documento del grupo de trabajo sobre registros de casos psiquiátricos.
- Author
- Publication venue
- Asociación Española de Neuropsiquiatría
- Publication date
- 01/01/1992
- Field of study
Sin resumen
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
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- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
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- Bodí M
- Boer C
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- Bougouin W
- Bourenne J
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- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
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- Braschi A
- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
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- Brody DL
- Brook R
- Brousseau C
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- Brugger SC
- Brugger SC
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- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
- Burtin P
- Busico M
- Butler MB
- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
- Cabrera JL
- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
- Cameron C
- Campbell R
- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
- Carmona SA
- Carmona SA
- Carone M
- Carpio D
- Carratalá A
- Carreira MM
- Carrero-Gómez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- Cerović O
- Cha YS
- Chabanne R
- Chacon-Alves S
- Champigneulle B
- Champigneulle B
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- Chan KK
- Chan WS
- Chang CH
- Chang WY
- Chao A
- Chao A
- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
- Citerio G
- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
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- Conti G
- Contreras KM
- Contreras MR
- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
- Corona A
- Corradi F
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- Corte FD
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- Cottle D
- Cotton H
- Cotton H
- Courant P
- Cowan R
- Creagh-Brown B
- Cressoni M
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Crimella F
- Cron N
- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
- Desmard M
- Deveugele M
- Deye N
- Di Bello F
- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
- Di Rosso R
- Diaz DD
- Diaz P
- Dilek M
- Dilly MP
- Dima E
- Dimitroulakis K
- Dimitrov BD
- Dimitrov BD
- Dimopoulou IK
- Dinh A
- Divatia JV
- Dixon J
- Doganci M
- Doglia JA
- Doherty P
- Dolset RA
- Dominguez JP
- Domínguez JP
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- Donnino M
- Doorduin J
- Dorent R
- Dos Reis Miranda D
- Dos Santos HP
- Dougall PC
- Doyle J
- Doyle J
- Drover J
- Duarte R
- Dubois EA
- Dubrawski A
- Dubó S
- Dudas G
- Dudoignon E
- Dumas F
- Dunthorne E
- Duran N
- Durand M
- Durovray JD
- Durrant J
- Duzgun M
- Díaz E
- Díaz JJ
- Díaz M
- Díaz PV
- Dünser MW
- E Silva ZC
- E YY
- Ebeling G
- Echeverri JE
- Echeverría JG
- Ediboglu O
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- Egea-Guerero JJ
- Egginton JS
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- El Hamid MA
- El Hossainy R
- El Sayed E
- El Sayed F
- El Sayed I
- El-Hamamsy M
- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
- Escalada SH
- Escalada SH
- Escoval A
- Escribá A
- Escórcio S
- Eslami S
- Espinasse F
- Espinel E
- Estagnasie P
- Esteban A
- Estella A
- Estenssoro E
- Evelein-Brugman S
- Facchin F
- Faivre V
- Fang M
- Fanzaghi P
- Farias P
- Faulds MC
- Fave G
- Feehan A
- Feijoo AM
- Feliot E
- Ferez MA
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- Fernandez NG
- Fernandez R
- Fernandez-Zamora MD
- Fernández IF
- Fernández L
- Fernández MV
- Fernández PA
- Fernández-Barat L
- Fernández-Mondéjar E
- Fernández-Ortega JF
- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
- Ferré A
- Ferrón FR
- Ferrón FR
- Fiks T
- Fiks T
- Fileković S
- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
- Floccard B
- Flowers E
- Follin A
- Follin A
- Fong KY
- Fontaiña LP
- Fontana V
- Fontenot T
- Forel JM
- Forni L
- Forni L
- Forni LG
- Forni LG
- Forni LG
- Fournel E
- Fox B
- Franchi P
- Francioni JE
- Francioni JE
- Franco JF
- Frantzeskaki F
- Frantzeskaki F
- Frat JP
- Frat JP
- Frat JP
- Freile MT
- Frenzel T
- Frigeni B
- Frithiof R
- Fritz C
- FROG ICU Investigators
- Fromentin M
- Frontera PR
- Fuentes M
- Fumagalli F
- Fumagalli F
- Fumis RR
- Fushimi K
- Gabán-Díez Á
- Gadgil S
- Gaide-Chevronnay L
- Gainnier M
- Gaite FB
- Gaizauskas E
- Gajic O
- Galache JA
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- Gameiro J
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- Gandini L
- Gando S
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- Gandola A
- Gandolfi S
- Ganuza MS
- Garcia IP
- Garcia IP
- Garcia M
- Garcia PK
- Garcia-Alvarez JM
- Garcia-Alvarez JM
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- Garcia-Gigorro R
- García MF
- García-Martínez MV
- García-Olivares P
- Garnacho-Montero J
- Garrido BB
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- Garrido EM
- Garrouste M
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- Gasparovic V
- Gattinoni L
- Gaudard P
- Gavranovic Z
- Gavrychenko D
- Gayat E
- Geantot MA
- Gemmell L
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- Genc D
- Genève C
- Georgopoulos D
- Geri G
- GETGAG Working Group
- GETGAG/SEMICYUC
- Ghabina S
- Ghazal S
- Gherli T
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- Giannantonio M
- Giannopoulos A
- Giesinger RE
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- Gimenez J
- Gimillo MR
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- Gioia A
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- Glogoski MZ
- Gobert F
- Godinho I
- Godoy K
- Goldsworthy M
- Golovnya E
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- Gomez SE
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- Gommers D
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- González-Jiménez AI
- Gonçalves B
- Goodwin S
- Gopcevic A
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- Gouveia J
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- Granada RM
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- Grassi L
- Grasso S
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- Green RS
- Greer M
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- Grossestreuer A
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- Gubianas CM
- Guerrero AP
- Guerrero JE
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- Guervilly C
- Guidet B
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- Guillen JA
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- Gupta A
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- Gustad LT
- Gutierrez LA
- Gutiérrez-Pizarraya A
- Guérin C
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- Géri G
- Gómez LC
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- Hatakeyama J
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- Helmy TA
- Helyar S
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- Hendra H
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- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
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- Hernández AA
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- Herpain A
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- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
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- Hidalgo C
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- Hirata A
- Hirayama T
- Hirohata S
- Hodgson LE
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- Hofmeijer J
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- Horvat A
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- Houzé S
- Houzé S
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- Hraiech S
- Hravnak M
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- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
- Hung WT
- Hung WT
- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
- Iotti GA
- Iotti GA
- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
- Izdes S
- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
- Jeong WY
- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
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- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
- Kang PL
- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
- Ke MW
- Keep J
- Keep J
- Keller E
- Kellner F
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- Kleinpell R
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- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
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- Kosuk ME
- Kotsopoulos A
- Kou PS
- Kouatchet A
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- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
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- Kruger A
- Krüger A
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- Ku NS
- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
- Kyle UG
- Labaune MA
- Labra C
- Lacerda P
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- Lafaurie M
- Lafuente E
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- Lagos R
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- Latini R
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- Leonard H
- Leone M
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- Lerma FA
- Lesmes SP
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- Lesmes SP
- Lesmes SP
- Lesmes SP
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- Lheureux O
- Lheureux O
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- Lichtenstein D
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- Lin KC
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- Lin PH
- Lin SC
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- Lin WC
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- Lischinsky A
- Lissonde F
- Lissonde F
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- Liu CP
- Liu CP
- Liu CP
- Liu CP
- Liu D
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- Llorente B
- Llorente MÁ
- Lobato MS
- Lobo-Civico A
- Loizou C
- Lombardo MD
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- Lopez R
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- Lortat-Jacob B
- Lortat-Jacob B
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- Louf-Durier A
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- Lukaszewicz AC
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- MacKay A
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- Mackey G
- MacPhee I
- Macrì M
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- Maekawa K
- Maekawa K
- Maekawa K
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- Maghsoudi B
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- Magnoni S
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- Maistry N
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- Marcos-Zambrano LJ
- Mariani M
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- Martínez-Carmona JF
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- Melo N
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- Menendez R
- Mengelle C
- Mercat A
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- Mergulhão PJ
- Merino-Vega D
- Messenger D
- Mezidi M
- Mezidi M
- Michel L
- Midwinter MJ
- Mignot T
- Miguelena PR
- Mihara Y
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- Olaechea P
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- Spadaro S
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- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
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- Stamm J
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- Stocchetti N
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- Stretti F
- Struijs A
- Stubbs C
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- Su L
- Su PL
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- Suchomel P
- Suh GJ
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- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
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- Taccone FS
- Taccone FS
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- Taggu A
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- Takeda M
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- Takei T
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- Tamura T
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- Tang KB
- Tang LK
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- Tapponnier R
- Tapponnier R
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- Temprano-Gómez I
- Tena SA
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- Terzi N
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- Terzi N
- Terzi N
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- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
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- Tomas E
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- Tonetti T
- Tonetti T
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- Tormos P
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- Vourli S
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- Vázquez CF
- Vázquez CF
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- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt AH
- Abedi Vida
- Adams Hieab
- Adebajo OJ
- Adeoye AM
- Afzal S
- Ago Tetsuro
- Agunloye A
- Akinyemi J
- Akinyemi Rufus
- Akpa O
- Akpalu A
- Almgren P
- Alvarez-Sabin J
- Amin N
- Amouyel Philippe
- Anderson CD
- Anderson Christopher D.
- Aparicio HJ
- Arenillas JF
- Armasu SM
- Armstrong Nicole D.
- Arnett DK
- Arulogun O
- Attia J
- Ay H
- Bae Hee-Joon
- Bakker Mark K.
- Bammler TK
- Bartz Traci M.
- Bastarache Lisa
- Beiser AS
- Bell S
- Benavente OR
- Benn M
- Bennett David A.
- Berr C
- Bevan S
- Bis JC
- Bis Joshua C.
- Blay N
- Boerwinkle E
- Boncoraglio GB
- Bordes Constance
- Braekkan SK
- Brody JA
- Brouwers PJAM
- Brown RD
- Brumpton BM
- Buring JE
- Bustamante M
- Butterworth AS
- Børte Sigrid
- Cain Anael
- Campos F
- Camps-Renom P
- Caro Ilana
- Carrera C
- Carty CL
- Caso V
- Castillo J
- Chasman Daniel I.
- Chauhan Ganesh
- Chen JS
- Chen MH
- Chen Pei-Hsin
- Chen WM
- Chen YP
- Chen Zhengming
- Cheng YC
- Cho Kelly
- Choi SH
- Chong Michael R.
- Chowhan A
- Christensen Kaare
- Clarke R
- Cole John W.
- Collins R
- Correa A
- Cotlarciuc I
- Cruchaga Carlos
- Cullell N
- Curtze S
- Cushman M
- Cárcel-Márquez Jara
- Damrauer Scott M.
- Danesh J
- Dartigues JF
- de Andrade M
- de Bakker PIW
- de Cid R
- de Cid Rafael
- de Jager Phil L.
- de Jager PL
- de Kort PL
- de Laat KF
- de Leeuw FE
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran H
- Deleuze JF
- Delgado P
- Delgado-Mederos R
- den Heijer T
- den Hoed M
- DeStefano AL
- Dhar R
- Diaz-Navarro R
- Dichgans Martin
- Dorr M
- Duan Q
- Ellekjaer H
- Endres Matthias
- Engelter ST
- Engstrom G
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Fakunle AG
- Falcone GJ
- Fernández-Cadenas Israel
- Ferreira LE
- Ferreira Leslie E.
- Fongang B
- Ford I
- Fornage Myriam
- Frantz S
- França Paulo H. C.
- Frazer KA
- Freijo M
- Frikke-Schmidt Ruth
- Fritsche LG
- Furie KL
- Gabrielsen ME
- Gallego-Fabrega C
- Gasca Natalie C.
- Gasca NC
- Geerlings MI
- Geerlings Mirjam I.
- Georgakis Marios K.
- Germain M
- Ghanbari M
- Gieger Christian
- Giese AK
- Giulianini F
- Gons RAR
- Gordon W
- Gottesman RF
- Grabe Hans J.
- Gravel S
- Gretarsdottir S
- Grewal RP
- Gudnason V
- Gudnason Vilmundur
- Guo Y
- Gurpreet WS
- Gustafsson S
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler J
- Haeusler Karl Georg
- Hagen K
- Hamsten A
- Hansen JB
- Harris TB
- Hassan A
- Hata Jun
- Havulinna Aki S.
- He Jing
- He Yunye
- Heath AK
- Heath Alicia K.
- Heckbert SR
- Heit JA
- Heitsch L
- Heuch I
- Heuschmann Peter Ulrich
- Hill M
- Ho Yuk-Lam
- Holliday EG
- Hopewell Jemma C.
- Howard G
- Howson Joanna M. M.
- Hozawa A
- Hsu FC
- Huffman Jennifer E.
- Hveem K
- Hyacinth Hyacinth I.
- Ibanez L
- Ibrahim M
- Ikram MK
- Ikram Mohammad A.
- Ilinca A
- Ingelsson E
- Ingelsson M
- Inouye Michael
- Irvin Marguerite R.
- Irvin MR
- Iwasaki M
- Jackson RD
- Jacob Mina A.
- Jee Yon Ho
- Jenkins C
- Jensen GB
- Jeon Christina E.
- Jern Christina
- Jian XQ
- Jimenez-Conde J
- Johnson AD
- Johnson JA
- Jood K
- Jousilahti P
- Judy Renae L.
- Jukema J. Wouter
- Jung Keum J.
- Jürgenson Tuuli
- Kabrhel C
- Kaffashian S
- Kalra L
- Kamanu Frederick K.
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup PR
- Kanai M
- Kappelle LJ
- Keene Keith L.
- Kim BJ
- Kim J
- Kim Young Jin
- Kinnunen J
- Kissela BM
- Kitazono Takanari
- Kittner Steven J.
- Kjartansson O
- Kleindorfer DO
- Kleinschnitz C
- Kloss M
- Knol Maria J.
- Koido Masaru
- Komolafe M
- Konuma Takahiro
- Kooperberg C
- Koudstaal PJ
- Kraft P
- Krebs Kristi
- Kristoffersen ES
- Krupinski J
- Kubo M
- Kumar Amit
- Kõrv Janika
- Labovitz DL
- Lacaze Paul
- Lange LA
- Langefeld CD
- Langenberg C
- Lathrop G. Mark
- Launer Lenore J.
- Laurie CC
- Le Grand Q
- Le Grand Quentin
- Lee JM
- Lee Keon-Joo
- Lee TH
- Lemmens R
- Lemmons R
- Leonard Hampton L.
- Lepik Kaido
- Levi CR
- Lewis Adam J.
- Lewis CM
- Leys D
- Li Jiang
- Li Liming
- Li LN
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin WY
- Lind L
- Lindgren AG
- Lindgren CM
- Lindstrom S
- Linkohr B
- Lioutas V
- Liu YM
- Lledos M
- Llucia-Carol L
- Longstreth W. T.
- Lopez OL
- Lopez-Cancio E
- Lorentzen E
- Luijckx GJ
- Lv J
- MacDonald J
- Magi R
- Magnusson PK
- Maguire J
- Makoto H
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S.
- Marston Nicholas A.
- Marti-Fabregas J
- Martinez-Majander N
- Martinsen AE
- Matsuda K
- Mayerhofer Ernst
- McArdle PF
- McCauley BM
- McDonough CW
- McKnight B
- Meitinger Thomas
- Melander O
- Menon V
- Meschia JF
- Metspalu A
- Milani Lili
- Millan M
- Millwood Iona Y.
- Minegishi N
- Mishra Aniket
- Mitchell Braxton D.
- Molina CA
- Montaner J
- Montellano Felipe A.
- Morange PE
- Morisaki Takayuki
- Morris AP
- Mosley Thomas H.
- Muino E
- Muller-Nurasyid M
- Munoz-Narbona L
- Murakami Y
- Nagai A
- Nalls Mike A.
- Namba Shinichi
- Nederkoorn PJ
- Nelis M
- Nielsen JB
- Niiranen Teemu J.
- Ninomiya Toshiharu
- Nordestgaard BG
- Nordestgaard Børge G.
- Norrving B
- Nygaard Marianne
- O'Donnell CJ
- O'Donnell Martin J.
- Obach V
- Obiako R
- Ogbole G
- Ogishima S
- Okada Yukinori
- Olalere A
- Onland-Moret N. Charlotte
- Onland-Moret NC
- Osaigbovo G
- Ovbiagele Bruce
- Owolabi L
- Owolabi Mayowa O.
- Pankow JS
- Pankratz N
- Parati EA
- Parodi Livia
- Paré Guillaume
- Pattee JW
- Peddareddygari LR
- Pedersen LM
- Pedersen NL
- Pera J
- Perola M
- Peters Annette
- Peto R
- Pezzini A
- Pileggi S
- Posner Daniel C.
- Pozarickij A
- Prasad Kameshwar
- Prats-Sanchez L
- Psaty Bruce M.
- Pulit SL
- Putaala J
- Puurunen MK
- Rabionet R
- Rannikmae K
- Reiner A
- Reiner AP
- Rexrode KM
- Riaz Moeen
- Riba-Llena I
- Ribases M
- Ribo M
- Rice K
- Rich Stephen S.
- Ridker Paul M.
- Rissanen Ina L.
- Rolfs A
- Romero JR
- Roquer J
- Rosand Jonathan
- Rosendaal FR
- Roshchupkin Gennady V.
- Ross OA
- Rost NS
- Rothwell PM
- Rotter Jerome I.
- Rudd AG
- Ruff Christian T.
- Ruigrok Ynte M.
- Rundek Tatjana
- Rutten-Jacobs L
- Sabatine Marc S.
- Sacco Ralph L.
- Saillour-Glenisson F
- Sakaue S
- Sale MM
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera DK
- Sapkota BR
- Sarfo FS
- Sargurupremraj M
- Sargurupremraj Muralidharan
- Sarin AP
- Sarju R
- Sarnowski C
- Sasaki Makoto
- Satizabal Claudia L.
- Satoh M
- Sattar N
- Sawada N
- Schmidt Carsten O.
- Schmidt D
- Schmidt R
- Schminke U
- Schnohr P
- Segura T
- Serrano-Heras G
- Seshadri Sudha
- Sharma P
- Shi Mingyang
- Shimizu Atsushi
- Shiroma EJ
- Sibolt G
- Sigurdsson A
- Sigurdsson S
- Simonsick Eleanor M.
- Skogholt AH
- Sloane Kelly L.
- Slowik A
- Smith A
- Smith EN
- Smith Nicholas L.
- Sobrino T
- Sobue K
- Soderholm M
- Soriano-Tarraga C
- Srinivasasainagendra Vinodh
- Stanne TM
- Stefansson K
- Stevens B
- Stine OC
- Stott DJ
- Strauch K
- Strbian Daniel
- Suchon P
- Sudlow CLM
- Sumoy L
- Sun Yan V.
- Sung YJ
- Sutoh Yoichi
- Takai T
- Tanaka H
- Tang WH
- Tanislav C
- Tanno Kozo
- Tatlisumak Turgut
- Taylor KD
- Teumer A
- Thijs VNS
- Thomas LF
- Thomassen Jesper Qvist
- Thorleifsson G
- Thorsteinsdottir U
- Tiainen M
- Tiedt Steffen
- Tiwari Hemant K.
- Tomppo Liisa
- Torres-Aguila Nuria P.
- Touze E
- Traylor M
- Trompet Stella
- Trégouët David-Alexandre
- Tsugane S
- Tuladhar Anil Man
- Turman C
- Turnbull I
- Tybjærg-Hansen Anne
- Tzourio C
- Uitterlinden AG
- Ungethum K
- Uvere E
- Valdimarsson EM
- van der Laan SW
- van der Lee SJ
- van Dijk EJ
- van Dijk GW
- van Duijn CM
- van Norden AGW
- van Oostenbrugge RJ
- van Rooij FGW
- van Setten J
- van Vugt M
- van Vugt Marion
- Vaura Felix C.
- Verma SS
- Verma Stefali S.
- Vermeer SE
- Vibo Riina
- Visser MC
- Vives-Bauza C
- Vlieg AV
- Volker U
- Volzke H
- Vonk JMJ
- Wahab K
- Wakai K
- Walters M
- Walters Robin G.
- Wang C
- Wang L
- Wang RQ
- Wareham NJ
- Wassertheil-Smoller Sylvia
- Weir D
- Wennberg Patrik
- Wermer MJH
- Wiggins Kerri L.
- Willer CJ
- Williams SR
- Wilson JG
- Wilson Peter W. F.
- Winsvold Bendik Slagsvold
- Wolfe CDA
- Wong QN
- Woo Daniel
- Worrall Bradford B.
- Xu Huichun
- Yaffe K
- Yamaji T
- Yang Chaojie
- Yang CR
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu CQ
- Yusuf S
- Zand Ramin
- Zhou W
- Zonderman AB
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/12/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.</p
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt AH
- Abedi V
- Adams H
- Adebajo OJ
- Adeoye AM
- Afzal S
- Ago T
- Agunloye A
- Akinyemi J
- Akinyemi R
- Akpa O
- Akpalu A
- Almgren P
- Amin N
- Amouyel P
- Anderson CD
- Anderson CD
- Aparicio HJ
- Arenillas JF
- Armasu SM
- Armstrong ND
- Arnett DK
- Arulogun O
- Attia J
- Ay H
- Bae H-J
- Bakker MK
- Bammler TK
- Bartz TM
- Bastarache L
- Beiser AS
- Beiser AS
- Bell S
- Benavente OR
- Benn M
- Bennett DA
- Berr C
- Bevan S
- Bis JC
- Bis JC
- Blay N
- Boerwinkle E
- Boncoraglio GB
- Bordes C
- Braekkan SK
- Brody JA
- Brouwers PJAM
- Brown RD
- Brumpton BM
- Brumpton BM
- Buring JE
- Bustamante M
- Butterworth AS
- Børte S
- Cain A
- Campos F
- Camps-Renom P
- Caro I
- Carrera C
- Carty CL
- Caso V
- Castillo J
- Chasman DI
- Chauhan G
- Chen J
- Chen M-H
- Chen P-H
- Chen W-M
- Chen WM
- Chen Y
- Chen Z
- Cheng Y-C
- Cho K
- Choi SH
- Chong MR
- Chowhan A
- Christensen K
- Clarke R
- Cole JW
- Collins R
- Correa A
- Cotlarciuc I
- Cruchaga C
- Cullell N
- Curtze S
- Cushman M
- Cárcel-Márquez J
- Damrauer SM
- Danesh J
- Dartigues J-F
- De Andrade M
- De Bakker PIW
- De Cid R
- De Cid R
- De Jager PL
- De Jager PL
- De Kort PL
- De Laat KF
- De Leeuw F-E
- De Leeuw F-E
- Debette S
- Delavaran H
- Deleuze J-F
- Delgado P
- Delgado P
- Delgado-Mederos R
- Den Heijer T
- Den Hoed M
- DeStefano AL
- Dhar R
- Diaz-Navarro R
- Dichgans M
- Duan Q
- Dörr M
- Ellekjær H
- Endres M
- Engelter ST
- Engström G
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Fakunle AG
- Falcone GJ
- Fernández-Cadenas I
- Ferreira LE
- Ferreira LE
- Fongang B
- Ford I
- Fornage M
- Frantz S
- França PHC
- Frazer KA
- Freijó M
- Frikke-Schmidt R
- Fritsche LG
- Furie KL
- Gabrielsen ME
- Gabrielsen ME
- Gallego-Fabrega C
- Gasca NC
- Gasca NC
- Geerlings MI
- Geerlings MI
- Georgakis MK
- Germain M
- Ghanbari M
- Gieger C
- Giese A-K
- Giese A-K
- Giulianini F
- Gons RAR
- Gordon W
- Gottesman RF
- Gottesman RF
- Gottesman RF
- Grabe HJ
- Gravel S
- Gretarsdottir S
- Grewal RP
- Gudnason V
- Gudnason V
- Guo Y
- Gurpreet WS
- Gustafsson S
- Habib N
- Hachiya T
- Haessler J
- Haessler J
- Haeusler KG
- Hagen K
- Hamsten A
- Hansen J-B
- Harris TB
- Hassan A
- Hata J
- Havulinna AS
- He J
- He Y
- Heath AK
- Heath AK
- Heckbert SR
- Heit JA
- Heitsch L
- Heuch I
- Heuschmann PU
- Hill M
- Ho Y-L
- Holliday EG
- Hopewell JC
- Howard G
- Howson JMM
- Hozawa A
- Hsu F-C
- Huffman JE
- Hveem K
- Hveem K
- Hyacinth HI
- Ibañez L
- Ibrahim M
- Ikram MA
- Ikram MK
- Ilinca A
- Ingelsson E
- Ingelsson M
- Inouye M
- Irvin MR
- Irvin MR
- Iwasaki M
- Jackson RD
- Jackson RD
- Jacob MA
- Jee YH
- Jenkins C
- Jensen GB
- Jeon CE
- Jern C
- Jian X
- Jiménez-Conde J
- Johnson AD
- Johnson JA
- Jood K
- Jousilahti P
- Judy RL
- Jukema JW
- Jung KJ
- Jürgenson T
- Kabrhel C
- Kaffashian S
- Kalra L
- Kamanu FK
- Kamatani Y
- Kamouchi M
- Kamstrup PR
- Kanai M
- Kappelle LJ
- Keene KL
- Kim B-J
- Kim J
- Kim YJ
- Kinnunen J
- Kissela BM
- Kitazono T
- Kittner SJ
- Kjartansson O
- Kleindorfer DO
- Kleinschnitz C
- Kloss M
- Knol MJ
- Koido M
- Komolafe M
- Konuma T
- Kooperberg C
- Kooperberg C
- Koudstaal PJ
- Kraft P
- Krebs K
- Kristoffersen ES
- Krupinski J
- Kubo M
- Kumar A
- Kõrv J
- Labovitz DL
- Lacaze P
- Lange LA
- Langefeld CD
- Langenberg C
- Lathrop GM
- Launer LJ
- Laurie CC
- Le Grand Q
- Le Grand Q
- Lee J-M
- Lee K-J
- Lee T-H
- Lemmens R
- Lemmons R
- Leonard HL
- Lepik K
- Levi CR
- Lewis AJ
- Lewis CM
- Leys D
- Li J
- Li L
- Li L
- Liaw Y-C
- Liaw Y-P
- Liman T
- Lin K
- Lin W-Y
- Lind L
- Lindgren AG
- Lindgren CM
- Lindstrom S
- Linkohr B
- Lioutas V
- Liu YM
- Lledós M
- Llucià-Carol L
- Longstreth WT
- Lopez OL
- Lopez-Cancio E
- Lorentzen E
- Luijckx G-J
- Lv J
- MacDonald J
- Magnusson PK
- Maguire J
- Makoto H
- Malik R
- Manichaikul A
- Markus HS
- Marston NA
- Martinez-Majander N
- Martinsen AE
- Martí-Fàbregas J
- Matsuda K
- Mayerhofer E
- McArdle PF
- McCauley BM
- McDonough CW
- McKnight B
- Meitinger T
- Melander O
- Menon V
- Meschia JF
- Metspalu A
- Milani L
- Millwood IY
- Millán M
- Minegishi N
- Mishra A
- Mitchell BD
- Molina CA
- Montaner J
- Montellano FA
- Morange P-E
- Morisaki T
- Morris AP
- Mosley TH
- Muiño E
- Murakami Y
- Muñoz-Narbona L
- Mägi R
- Müller-Nurasyid M
- Nagai A
- Nalls MA
- Namba S
- Nederkoorn PJ
- Nederkoorn PJ
- Nelis M
- Nielsen JB
- Nielsen JB
- Niiranen TJ
- Ninomiya T
- Nordestgaard BG
- Nordestgaard BG
- Norrving B
- Nygaard M
- Obach V
- Obiako R
- Ogbole G
- Ogishima S
- Okada Y
- Olalere A
- Onland-Moret NC
- Onland-Moret NC
- Osaigbovo G
- Ovbiagele B
- Owolabi L
- Owolabi MO
- O’Donnell CJ
- O’Donnell MJ
- Pankow JS
- Pankratz N
- Parati EA
- Parodi L
- Paré G
- Pattee JW
- Peddareddygari LR
- Pedersen LM
- Pedersen NL
- Pera J
- Perola M
- Peters A
- Peto R
- Pezzini A
- Pileggi S
- Posner DC
- Pozarickij A
- Prasad K
- Prats-Sánchez L
- Psaty BM
- Pulit SL
- Putaala J
- Puurunen MK
- Rabionet R
- Rannikmäe K
- Reiner A
- Reiner AP
- Rexrode KM
- Riaz M
- Riba-Llena I
- Ribasés M
- Ribó M
- Rice K
- Rich SS
- Ridker PM
- Rissanen IL
- Rolfs A
- Romero JR
- Roquer J
- Rosand J
- Rosendaal FR
- Roshchupkin GV
- Ross OA
- Rost NS
- Rothwell PM
- Rotter JI
- Rudd AG
- Ruff CT
- Ruigrok YM
- Rundek T
- Rutten-Jacobs L
- Sabatine MS
- Sacco RL
- Saillour-Glenisson F
- Sakaue S
- Sale MM
- Saleheen D
- Salomaa V
- Sandset EC
- Sanghera DK
- Sapkota BR
- Sarfo FS
- Sargurupremraj M
- Sargurupremraj M
- Sarin A-P
- Sarju R
- Sarnowski C
- Sasaki M
- Satizabal CL
- Satoh M
- Sattar N
- Sawada N
- Schmidt CO
- Schmidt D
- Schmidt R
- Schminke U
- Schnohr P
- Segura T
- Serrano-Heras G
- Seshadri S
- Sharma P
- Shi M
- Shimizu A
- Shiroma EJ
- Sibolt G
- Sigurdsson S
- Sigurdsson Á
- Simonsick EM
- Skogholt AH
- Sloane KL
- Slowik A
- Smith A
- Smith EN
- Smith NL
- Sobrino T
- Sobue K
- Soderholm M
- Soriano-Tárraga C
- Srinivasasainagendra V
- Stanne TM
- Stefansson K
- Stevens B
- Stine OC
- Stott DJ
- Strauch K
- Strbian D
- Suchon P
- Sudlow CLM
- Sumoy L
- Sun YV
- Sung YJ
- Sutoh Y
- Takai T
- Tanaka H
- Tang W
- Tanislav C
- Tanno K
- Tatlisumak T
- Taylor KD
- Taylor KD
- Teumer A
- Thijs VNS
- Thomas LF
- Thomassen JQ
- Thorleifsson G
- Thorsteinsdottir U
- Tiainen M
- Tiedt S
- Tiwari HK
- Tomppo L
- Torres-Aguila NP
- Touze E
- Traylor M
- Trompet S
- Trégouët D-A
- Tsugane S
- Tuladhar AM
- Turman C
- Turnbull I
- Tybjærg-Hansen A
- Tzourio C
- Uitterlinden AG
- Ungethüm K
- Uvere E
- Valdimarsson EM
- Van der Laan SW
- Van der Lee SJ
- Van Dijk EJ
- Van Dijk GW
- Van Duijn CM
- Van Hylckama Vlieg A
- Van Norden AGW
- Van Oostenbrugge RJ
- Van Rooij FGW
- Van Setten J
- Van Vugt M
- Van Vugt M
- Vaura FC
- Verma SS
- Verma SS
- Vermeer SE
- Vibo R
- Visser MC
- Vives-Bauza C
- Vonk JMJ
- Völker U
- Völzke H
- Wahab K
- Wakai K
- Walters M
- Walters RG
- Wang C
- Wang L
- Wang R
- Wareham NJ
- Wassertheil-Smoller S
- Weir D
- Wennberg P
- Wermer MJH
- Wiggins KL
- Willer CJ
- Williams SR
- Wilson JG
- Wilson PWF
- Winsvold BS
- Wolfe CDA
- Wong Q
- Woo D
- Worrall BB
- Xu H
- Yaffe K
- Yamaji T
- Yang C
- Yang C
- Yang Q
- Yonova-Doing E
- Yoon K
- Yu C
- Yusuf S
- Zand R
- Zhou W
- Zonderman AB
- Zwart J-A
- Álvarez-Sabín J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/07/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries