Hybridní organosilanové materiály a jejich aplikace v materiálovém inženýrství

Nanomaterials together with nanotechnologies bring everyday challenges to modern material science and allow scientists worldwide to develop completely new types of unique materials having extraordinary properties. Although interest in hybrid organic-inorganic organosilane fibrous nanomaterials is rising, there is no complete review and/or literature covering and completing the knowledge regarding this highly promissive research area. Todate, only a few solitary research papers have been published regarding this topic. Herein, organo-mono-silylated and organo-bis-silylated precursors were studied in detail. In addition, the proposed synthetic strategies together with their outcomes were successfully applied for the formation of organosilane fibers made of the above-mentioned hybrid precursors. The techniques of self-assembly, drawing, and in particular electrospinning, are widely discussed in the theoretical part of this thesis. The electrospinning technique was then directly used for the formation of organosilane fibers. The results related to this topic are present in the second part of this thesis. Moreover, they are supported by recently published articles, which are added to and described in the supplementary part of this habilitation thesis. The presented findings are closely connected to the application potential and show the unique and promising prospects of these hybrid organosilane fibers in various fields of modern material science covering a wide range of industries, including the textile industry, and particularly everyday life

Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA

Our study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson's disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle

Photochemically catalysed polymerisation of 3-trimethoxysilylpropyl methacrylate containing silver, copper and zinc ions

Photo curable organic-inorganic monomers are currently generating much interest in many research groups worldwide due to their unique properties leading to a wide range of applications including electronics, energetics, medicine, etc. One of them, 3-trimethoxysilylpropylmethacrylate belongs to the class of such monomers having a wide range of relatively good mechanical, chemical and physical properties. Moreover, this monomer can be cured by different processes including heat treatment and light. Photochemically catalysed polymerisation of sol prepared from 3-trimethoxysilylpropylmethacrylate hybrid monomer and titanium tetraisopropoxide containing silver, copper and zinc ions was tested with two commercially available photoinitiators, a Darocur 1173 and an Irgacure 819. The aim of this study was to propose conditions for the effective polymerisation process leading to the maximal conversion of double bonds present in the organic part of the hybrid monomer and observe the potential effect of the ions. Particularly the copper ions by themselves and/or in combination with silver ions inside the hybrid matrix may influence the speed and conversion degree of the photochemically catalysed polymerisation processes. © 2018 University of Chemistry and Technology, Faculty of Environmental Technology

A comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria

Hospital-acquired infections (HAI) caused by pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus adversely affect public health due to their colonization and subsequent formation of a biofilm on medical devices. Various functionalized polymers including polyamides are commonly used in the biomedical industry aiming to resist bacterial infection as well as to ensure cytocompatibility of the used materials. The present study is focused on the extension of our previous work that developed a new approach to immobilize mPEG on an amine-activated Nylon 6 surface. Herein, we compare functionalized samples of Nylon 6 together with samples additionally containing copper nanoparticles (Cu NPs, size 40-60 nm) physisorbed on a modified surface. Modified samples were analyzed via different techniques including water contact angle measurements, atomic force microscopy and scanning electron microscopy associated with energy dispersive Xray spectroscopy. The copper functionalized samples showed high antibacterial efficacy against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Moreover, most of the prepared samples were cytocompatible