67 research outputs found
Follow-up study of sensory-motor polyneuropathy in Type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection
The influence of successful simultaneous pancreas and kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following kidney-graft-rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-graft rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-graft-rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s.
In conclusion, we believe that strict normalization of glucose metabolism alters the progressive course of diabetic polyneuropathy. It may be stabilized or partly reversed after successful grafting even in long-term diabetic patients
Obesity and the Risk of Papillary Thyroid Cancer: A Pooled Analysis of Three Case-Control Studies.
Background: There is a correlation between temporal trends of obesity prevalence and papillary thyroid cancer
(PTC) incidence in the United States. Obesity is a well-recognized risk factor for many cancers, but there are
few studies on the association between obesity and PTC risk. We investigated the association between anthropometric
measurements and PTC risk using pooled individual data from three case–control populations.
Methods: Height and weight information were obtained from three independent case–control studies, including
1917 patients with PTC (1360 women and 557 men) and 2127 cancer-free controls from the United States, Italy,
and Germany. Body mass index (BMI), body fat percentage, and body surface area (BSA) were calculated. An
unconditional logistic regression model was used to calculate odds ratios (ORs) and confidence intervals (CIs)
with respect to risk of PTC, adjusted by age, sex, race/ethnicity, and study site.
Results: In the pooled population, for both men and women, an increased risk of PTC was found to be
associated with greater weight, BMI, body fat percentage, and BSA, whereas a reduced risk of PTC was
associated with greater height, in the pooled population for both men and women. Compared with normal-weight
subjects (BMI 18.5–24.9 kg/m2), the ORs for overweight (BMI 25–29.9 kg/m2) and obese (BMI ‡ 30 kg/m2)
subjects were 1.72 [CI 1.48–2.00] and 4.17 [CI 3.41–5.10] respectively. Compared with the lowest quartile of
body fat percentage, the ORs for the highest quartile were 3.83 [CI 2.85–5.15] in women and 4.05 [CI 2.67–
6.15] in men.
Conclusion: Anthropometric factors, especially BMI and body fat percentage, were significantly associated
with increased risk of PTC. Future studies of anthropometric factors and PTC that incorporate intermediate
factors, including adiposity and hormone biomarkers, are essential to help clarify potential mechanisms of the
relationship
Testing of Arg-8-gonadotropin-releasing hormone-directed antisera by immunological and immunocytochemical methods for use in comparative studies
Cyclosporine A enhances total cell calcium independent of Na-ATPase in vascular smooth muscle cells
Immunohistology of graft-versus-host disease mediated skin lesions and its correlation to a large granular lymphocyte surface phenotype and function
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