A Graph-Native Query Optimization Framework

Graph queries that combine pattern matching with relational operations, referred as PatRelQuery, are widely used in many real-world applications. It allows users to identify arbitrary patterns in a graph and further perform in-depth relational analysis on the results. To effectively support PatRelQuery, two key challenges need to be addressed: (1) how to optimize PatRelQuery in a unified framework, and (2) how to handle the arbitrary type constraints in patterns in PatRelQuery. In this paper, we present a graph-native query optimization framework named GOpt, to tackle these issues. GOpt is built on top of a unified intermediate representation (IR) that is capable of capturing both graph and relational operations, thereby streamlining the optimization of PatRelQuery. To handle the arbitrary type constraints, GOpt employs an automatic type inference approach to identify implicit type constraints. Additionally, GOpt introduces a graph-native optimizer, which encompasses an extensive collection of optimization rules along with cost-based techniques tailored for arbitrary patterns, to optimize PatRelQuery. Through comprehensive experiments, we demonstrate that GOpt can achieve significant query performance improvements, in both crafted benchmarks and real-world applications

Non-clostridial Gas-forming Infection in Diabetes：Clinical Analysis of Two Cases

Non-clostridial organism can produce pneumoderma by breaking down sugar and other substrates in necrotic tissues, and non-clostridial gas-forming infection is usually seen in diabetic patients with poor glycemic control. The differential diagnosis between clostridial and non-clostridial gas-forming infection relies on etiological examination results, but the key to successful treatment is timely empiric broad-spectrum antibiotic treatment and emergency surgical debridement in the absence of a definitive etiologic diagnosis. This paper reported two cases of non-clostridial gas-forming infection in diabetes, and reviewed relevant literature, aiming to improve clinicians' understanding of this disease

Generation and Bioenergetic Profiles of Cybrids with East Asian mtDNA Haplogroups

Human mitochondrial DNA (mtDNA) variants and haplogroups may contribute to susceptibility to various diseases and pathological conditions, but the underlying mechanisms are not well understood. To address this issue, we established a cytoplasmic hybrid (cybrid) system to investigate the role of mtDNA haplogroups in human disease; specifically, we examined the effects of East Asian mtDNA genetic backgrounds on oxidative phosphorylation (OxPhos). We found that mtDNA single nucleotide polymorphisms such as m.489T>C, m.10398A>G, m.10400C>T, m.C16223T, and m.T16362C affected mitochondrial function at the level of mtDNA, mtRNA, or the OxPhos complex. Macrohaplogroup M exhibited higher respiratory activity than haplogroup N owing to its higher mtDNA content, mtRNA transcript levels, and complex III abundance. Additionally, haplogroup M had higher reactive oxygen species levels and NAD+/NADH ratios than haplogroup N, suggesting difference in mitonuclear interactions. Notably, subhaplogroups G2, B4, and F1 appeared to contribute significantly to the differences between haplogroups M and N. Thus, our cybrid-based system can provide insight into the mechanistic basis for the role of mtDNA haplogroups in human diseases and the effect of mtDNA variants on mitochondrial OxPhos function. In addition, studies of mitonuclear interaction using this system can reveal predisposition to certain diseases conferred by variations in mtDNA

Characteristics and driving factors of fluoride in groundwater in different urban functional area of Lanzhou city

High-fluorine groundwater is a potential threat to ecological environment and human health. The source and distribution of fluoride in groundwater in urbanized areas are complicated due to the double influence of geological background and human activities. It is of great significance to identify the characteristics of fluorine in groundwater to ensure the safety of groundwater.This study analyzed the environmental characteristics and main hydrogeochemical processes of high-fluorine groundwater in different urban functional areas of Lanzhou city, the largest industrial city in the arid region of Northwest China, based on the mathematical statistics, ion ratios and saturation index analysis. Then the influence of human activities on the migration and enrichment of fluoride was revealed. The results show that the ρ(F−) in the groundwater in the study area ranges from 0 to 4.8 mg/L, and 13 high-fluoride water samples exceeded the standard of groundwater quality Class III (1.0 mg/L), with an excess rate of 20.3%. Under the influence of intensity of human activity and sources of human input, the distribution characteristics of fluorine in groundwater in different urban functional areas are prominently different. The fluorine content of groundwater in the Xigu Petrochemical Industrial Zone is the highest, with the 47.4% of high-fluorine groundwater. While in commercial residential areas and new urban areas the fluorine content is relatively low, with the 7.1% and 9.7% of high-fluorine groundwater, respectively. The high-fluorine groundwater in the study area is mainly SO4•Cl—Na and Cl•SO4—Na type water, which is low in calcium, rich in sodium and weak in alkalinity. The dissolution of fluorinated minerals, precipitation/dissolution of calcite and dolomite, cation exchange between calcium and sodium on the surface of clay minerals, strong evaporation and salt effect are the main hydrogeochemical processes of fluoride enrichment in groundwater in the study area. Urbanization and industrialization lead to the further deterioration of natural high fluorine water, the industrial wastewater leakage from petrochemical leads to the further dissolution of fluoride in the formation, which is an important driving force for the enrichment of high fluorine groundwater in the Xigu Industrial Zone. The study provides basic information for the fluoride migration and enrichment in the high fluoride background area with human activities

In-situ tunable giant electrical anisotropy in a grating gated AlGaN/GaN two-dimensional electron gas

Materials with in-plane electrical anisotropy have great potential for designing artificial synaptic devices. However, natural materials with strong intrinsic in-plane electrical anisotropy are rare. We introduce a simple strategy to produce extremely large electrical anisotropy via grating gating of a semiconductor two-dimensional electron gas (2DEG) of AlGaN/GaN. We show that periodically modulated electric potential in the 2DEG induces in-plane electrical anisotropy, which is significantly enhanced in a magnetic field, leading to an ultra large electrical anisotropy. This is induced by a giant positive magnetoresistance and a giant negative magnetoresistance under two orthogonally oriented in-plane current flows, respectively. This giant electrical anisotropy is in-situ tunable by tailoring both the grating gate voltage and the magnetic field. Our semiconductor device with controllable giant electrical anisotropy will stimulate new device applications, such as multi-terminal memtransistors and bionic synapses

GraphScope Flex: LEGO-like Graph Computing Stack

Graph computing has become increasingly crucial in processing large-scale graph data, with numerous systems developed for this purpose. Two years ago, we introduced GraphScope as a system addressing a wide array of graph computing needs, including graph traversal, analytics, and learning in one system. Since its inception, GraphScope has achieved significant technological advancements and gained widespread adoption across various industries. However, one key lesson from this journey has been understanding the limitations of a "one-size-fits-all" approach, especially when dealing with the diversity of programming interfaces, applications, and data storage formats in graph computing. In response to these challenges, we present GraphScope Flex, the next iteration of GraphScope. GraphScope Flex is designed to be both resource-efficient and cost-effective, while also providing flexibility and user-friendliness through its LEGO-like modularity. This paper explores the architectural innovations and fundamental design principles of GraphScope Flex, all of which are direct outcomes of the lessons learned during our ongoing development process. We validate the adaptability and efficiency of GraphScope Flex with extensive evaluations on synthetic and real-world datasets. The results show that GraphScope Flex achieves 2.4X throughput and up to 55.7X speedup over other systems on the LDBC Social Network and Graphalytics benchmarks, respectively. Furthermore, GraphScope Flex accomplishes up to a 2,400X performance gain in real-world applications, demonstrating its proficiency across a wide range of graph computing scenarios with increased effectiveness

Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

The term “tissue kallikrein” is used to describe a group of serine proteases shared considerable sequence homology and colocalize in the same chromosomal locus 19q13. 2–q13.4. It has been widely discovered in various tissues and has been proved to be involved in kinds of pathophysiological processes, such as inhibiting oxidative stress, inflammation, apoptosis, fibrosis and promoting angiogenesis, and neurogenesis. Human Urinary Kallidinogenase (HUK) extracted from human urine is a member of tissue kallikrein which could convert kininogen to kinin and hence improve the plasma kinin level. Medical value of HUK has been widely investigated in China, especially on acute ischemic stroke. In this review, we will summarize the therapeutic values of Human Urinary Kallidinogenase on acute ischemic stroke and its potential mechanisms

Public Health Emergency Command System of China

China has formed a national emergency management system consisting of “one contingency plan and three sets of institutions” since the outbreak of the severe acute respiratory syndrome (SARS) in 2003. This system is further improved after the establishment of the Ministry of Emergency Management in 2018 and the great achievements made in the fight against the coronavirus disease 2019 (COVID-19). This study aims to improve China’s public health emergency command system via investigating the history, current status, and challenges of the system. In this article, we summarize the emergency command systems responding to the SARS outbreak, the H1N1 2009 pandemic, and the COVID-19 pandemic using literature research, theoretical analysis, and case comparison. China’s public health emergency command system played a significant role in dealing with these public health emergencies and has been increasingly improved; however, it still faces various challenges. Therefore, we propose several policy suggestions to address these challenges, which involve the aspects of joint prevention and control mechanism, law system for public health emergencies, advisory board, and central–local relations