Dual-task speech performance in multiple sclerosis

Background: Although extant dual-task studies suggest cognitive-motor interference may magnify existing non-speech motor impairments in multiple sclerosis (MS), cognitive-speech motor interference in MS has not been studied. This study evaluated the presence of cognitive-speech motor interference in MS and explored within subject differences in speech measures from the single-to dual-task condition for individuals with MS with co-occurring dysarthria and impaired cognition. Methods: In this dual-task study, 21 individuals with MS and 21 controls read aloud a sentence (single-task) and completed a cognitive-linguistic task while simultaneously reading aloud a sentence (dual-task). Speech measures included speech and articulation rate, silent pause frequency and duration, and total sentence duration. Results: Both groups had significantly slower speech in the dual-task condition. Relative to participants with dysarthria, speech rate and sentence duration difference scores approached significance or were significantly greater for participants with MS with dysarthria and cognitive impairment. These difference scores were associated with executive function and processing speed deficits and fewer years of education. Conclusion: Significant negative compounding effects for speech rate and sentence duration suggest that the dual-task paradigm shows promise for identifying individuals with MS with cognitive impairment and dysarthria at increased risk of problems with effective communication. Further research is warranted to replicate this work and evaluate the consequences of these speech aberrancies on communication effectiveness that ultimately may affect employment, social relationships, and quality of life

Social Network Characteristics and Correlations With Cognitive, Psychosocial, and Speech Function and Communication Participation for Adults With Multiple Sclerosis: A Pilot Study

Purpose: This cross-sectional observational pilot study investigated egocentric social networks for 10 paired sex-and age-matched adults with and without multiple sclerosis (MS). This study also investigated the relationship between social network measures and various disease factors associated with MS. The relationship between social network measures and communication participation restrictions was also examined. Method: Participants completed a seven-item social network survey. Social network structure and composition were quantified. The network organization measures (structure analysis) included the total number of members (network size) and extent to which members are connected (network density). The measured characteristics of people around a participant (composition analysis) included the amount of kin relative to network size (proportion of kin), gender variation (gender diversity index), and age variation (standard deviation of age). Standard clinical neuropsychological, psychosocial, and speech metrics quantified processing speed, memory, depression, fatigue, and sentence intelligibility. Measures of communication participation and MS severity were also obtained. Results: Matched-pairs tests indicated that the proportion of kin significantly differed between paired participants, whereas all other social network measures were similar. For participants with MS, correlation analyses indicated weak associations between proportion of kin and cognitive, psychosocial, and speech measures. However, strong correlations were found between social network size and processing speed, memory, fatigue, MS severity, and communication participation. Gender diversity index also strongly correlated with depression. Conclusions: Results from this pilot study highlight the importance of evaluat-ing egocentric networks in the clinical management of MS, as maintaining non-kin friendships may be difficult for adults with MS making them vulnerable to social isolation. Furthermore, those with small and less diverse networks may experience more severe cognitive and psychosocial problems and limited communication participation

Linguistic performance during monologues and correlates of neuropsychological function for adults with multiple sclerosis

Background: Cognitive-linguistic deficits are a concern in multiple sclerosis (MS). Thus, clinical management requires knowledge of how impaired cognition associated with MS impacts language performance during everyday communication tasks. Aims: This study investigated language performance in narrative monologues produced by individuals with MS compared to healthy controls and the correlations between language performance and cognitive function for the individuals with MS. Method and Procedure: Thirteen individuals with MS and 13 controls were studied. Four neuropsychological tests from the Minimal Assessment of Cognitive Function in MS confirmed that individuals with MS had impaired cognition and an auditory-perceptual evaluation confirmed that they did not have dysarthria. Narratives were analyzed using the Systematic Analysis of Language Transcripts (SALT). Primary linguistic variables included inter-sentence cohesion adequacy, subordination index, moving average type-token ratio (MATTR), and mean length of utterances (MLU). Secondary linguistic measures included the total number of words, mazes, utterances, and abandoned utterances. Measures of disease severity, depression, and fatigue were also obtained. Outcome and Results: When controlling for age and fatigue, the total number of words was the only linguistic measure that significantly differed between groups. Participants with MS produced more words than controls. Significant correlations indicated strong associations between MATTR, MLU, abandoned utterances, and subordination index and the cognitive domains of processing speed and/or executive function. Conclusion: Results suggest that communicative competence during everyday speaking tasks may be undermined by off-topic verbose speech, reduced detail, and unfinished thoughts for individuals with MS with impaired processing speed and/or executive function

Global Acoustic Speech Temporal Characteristics for Mandarin Speakers With Parkinson\u27s Disease During Syllable Repetition and Passage Reading

PURPOSE: Previous research has revealed considerable variation in speech rates among English speakers with Parkinson\u27s disease (PD) with slower, faster, or similar rates than controls. The purpose of this study was to characterize speech rates of Mandarin speakers with PD and the corresponding articulation and pause characteristics explaining the speech rates to enhance rate control therapies. METHOD: Eighteen Mandarin speakers with PD and 18 controls produced syllable repetitions and passage reading using their typical speech style. Speech rates, articulation rates, mean pause durations (≥ 10 ms), and the number of pauses with duration between 10 ms and 300 ms and greater than 300 ms were measured and compared between groups and tasks as well as across the initial, middle, and final periods of the passage. Two-way, mixed-model analyses of variance were employed for data analysis. RESULTS: Compared to controls, individuals with PD spoke with similar speech rates and faster articulation rates during passage reading, whereas during syllable repetitions, they produced slower speech rates and comparable articulation rates. The slower syllable repetitions produced by speakers with PD may be explained by longer pauses and more perceptual pauses, whereas faster articulation rates may explain the trend of faster speech rates during reading. Speech and articulation rates accelerated for both groups during passage reading. CONCLUSIONS: Speech rates of Mandarin speakers with PD were characterized by faster articulation, longer pauses, and more perceptual pauses for passage reading. A descriptive model of speech rate suggested that speakers with PD and dysarthria in this study would benefit from rate reduction therapy decreasing articulation rate. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.23982282

Relationship between acoustic measures and judgments of intelligibility in Parkinson\u27s disease: A within-speaker approach

This study investigated the acoustic basis of within-speaker, across-utterance variation in sentence intelligibility for 12 speakers with dysarthria secondary to Parkinson\u27s disease (PD). Acoustic measures were also obtained for 12 healthy controls for comparison to speakers with PD. Speakers read sentences using their typical speech style. Acoustic measures of speech rate, articulatory rate, fundamental frequency, sound pressure level and F2 interquartile range (F2 IQR) were obtained. A group of listeners judged sentence intelligibility using a computerized visual-analog scale. Relationships between judgments of intelligibility and acoustic measures were determined for individual speakers with PD. Relationships among acoustic measures were also quantified. Although considerable variability was noted, articulatory rate, fundamental frequency and F2 IQR were most frequently associated with within-speaker variation in sentence intelligibility. Results suggest that diversity among speakers with PD should be considered when interpreting results from group analyses

Speech timing changes accompany speech entrainment in aphasia

Background: Prior speech entrainment studies, where individuals with non-fluent aphasia mimic an audio-visual model, suggest speech entrainment improves speech fluency, as indexed by various linguistic measures (e.g., the total number of different words produced per minute). Here, more precise speech timing adjustments accompanying entrained speech were studied and compared to spontaneous speech to determine how these temporal variables relate to the fluency inducing effects of speech entrainment in aphasia. Methods: Thirty-one left hemisphere stroke survivors classified with fluent or non-fluent speech were audio-video recorded as they described a picture and during speech entrainment. Speech fluency was documented using the Western Aphasia Battery-Revised. Acoustic measures of speech timing included total number of syllables, speech rate, articulatory rate, silent pause frequency and duration. Standard descriptive statistics and a two-factor mixed model analysis of variance were used to investigate group, task, and ‘group x task’ interaction effects. Findings: All acoustic measures of speech timing differentiated the fluent and nonfluent groups except for silent pause frequency. Differences between speech entrainment and spontaneous speech were found for most acoustic measures of speech timing and speaker groups, yet the direction of the effect varied. Stroke survivors classified with non-fluent aphasia improved speech fluency such that speech entrainment elicited pause adjustments facilitating more typical speech timing in comparison to spontaneous speech. Conclusion: Overall, findings provide further evidence of the impact of speech entrainment on measures of speech timing to help individuals with non-fluent aphasia to practice speaking more fluently. Practicing speaking more fluently may ultimately impact perceptual judgments of speech naturalness and social acceptance for persons with aphasia

Separate and combined influence of cognitive impairment and dysarthria on functional communication in multiple sclerosis

Purpose: Dysarthria is a consequence of multiple sclerosis (MS) that can co-occur with cognitive impairment. Clinical management thus requires understanding the separate and combined effects of dysarthria and cognitive impairment on functional communication in MS. This study compared perceptual measures of intelligibility and speech severity that capture functional communication deficits for 4 operationally defined groups with MS. The relationship between communication participation and perceptual measures was also examined. Method: Forty-eight adults with MS and 12 healthy controls participated. Cognitive testing and dysarthria diagnosis determined group assignment: (a) MS with cognitive impairment (MSCI), (b) MS with a diagnosis of dysarthria and no cognitive impairment (MSDYS), (c) MS with dysarthria and cognitive impairment (MSDYS + CI), and (d) MS without dysarthria or cognitive impairment (MS). Sentence Intelligibility Test scores, scaled speech severity obtained from the “Grandfather Passage,” and Communication Participation Item Bank (CPIB) scores were analyzed. Results: Sentence Intelligibility Test scores approached 100% for all groups. Speech severity was greater for the MSDYS + CI and MSDYS groups versus controls. CPIB scores were greatest for the MSDYS + CI group and were not significantly correlated with either perceptual measure. Conclusions: The CPIB and speech severity were sensitive to aspects of communication problems for some groups with MS not reflected in a measure of sentence intelligibility. Findings suggest the importance of employing a variety of measures to capture functional communication problems experienced by persons with MS

Speech and pause characteristics in multiple sclerosis: A preliminary study of speakers with high and low neuropsychological test performance

This preliminary study investigated how cognitive-linguistic status in multiple sclerosis (MS) is reflected in two speech tasks (i.e. oral reading, narrative) that differ in cognitive-linguistic demand. Twenty individuals with MS were selected to comprise High and Low performance groups based on clinical tests of executive function and information processing speed and efficiency. Ten healthy controls were included for comparison. Speech samples were audio-recorded and measures of global speech timing were obtained. Results indicated predicted differences in global speech timing (i.e. speech rate and pause characteristics) for speech tasks differing in cognitive-linguistic demand, but the magnitude of these task-related differences was similar for all speaker groups. Findings suggest that assumptions concerning the cognitive-linguistic demands of reading aloud as compared to spontaneous speech may need to be re-considered for individuals with cognitive impairment. Qualitative trends suggest that additional studies investigating the association between cognitive-linguistic and speech motor variables in MS are warranted. © 2013 Informa UK Ltd

Chronic post-stroke aphasia severity is determined by fragmentation of residual white matter networks

Many stroke survivors with aphasia in the acute period experience spontaneous recovery within the first six months after the stroke. However, approximately 30-40% sustain permanent aphasia and the factors determining incomplete recovery are unclear. Suboptimal recovery may be influenced by disruption of areas seemingly spared by the stroke due to loss of white matter connectivity and network integrity. We reconstructed individual anatomical whole-brain connectomes from 90 left hemisphere stroke survivors using diffusion MR images. We measured the modularity of the residual white matter network organization, the probability of brain regions clustering together, and the degree of fragmentation of left hemisphere networks. Greater post-stroke left hemisphere network fragmentation and higher modularity index were associated with more severe chronic aphasia, controlling for the size of the stroke lesion. Even when the left hemisphere was relatively spared, subjects with disorganized community structure had significantly worse aphasia, particularly when key temporal lobe regions were isolated into segregated modules. These results suggest that white matter integrity and disorganization of neuronal networks could be important determinants of chronic aphasia severity. Connectome white matter organization measured through modularity and other topological features could be used as a personalized variable for clinical staging and aphasia treatment planning