35,600 research outputs found

    Is Therapeutic Abortion Scientifically Justified?

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    Aerosol studies in mid-latitude coastal environments in Australia

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    The results of the evaluation of several inversion procedures that were used to select one which provides the most accurate atmospheric extinction profiles for small aerosol extinction coefficients (that often predominate in the maritime airmass) are presented. Height profiles of atmospheric extinction calculated by a two component atmospheric solution to the LIDAR equation will be compared with corresponding in-situ extinction profiles based on the size distribution profiles obtained in Western Australia. Values of the aerosol backscatter to extinction ratio obtained from multi-angle LIDAR measurements will be used in this solution

    Adaptive evolution of molecular phenotypes

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    Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under time-dependent selection, which arises from environmental changes or through fitness interactions with other co-evolving phenotypes. We analyze a model of trait evolution under mutations and genetic drift in a single-peak fitness seascape. The fitness peak performs a constrained random walk in the trait amplitude, which determines the time-dependent trait optimum in a given population. We derive analytical expressions for the distribution of the time-dependent trait divergence between populations and of the trait diversity within populations. Based on this solution, we develop a method to infer adaptive evolution of quantitative traits. Specifically, we show that the ratio of the average trait divergence and the diversity is a universal function of evolutionary time, which predicts the stabilizing strength and the driving rate of the fitness seascape. From an information-theoretic point of view, this function measures the macro-evolutionary entropy in a population ensemble, which determines the predictability of the evolutionary process. Our solution also quantifies two key characteristics of adapting populations: the cumulative fitness flux, which measures the total amount of adaptation, and the adaptive load, which is the fitness cost due to a population's lag behind the fitness peak.Comment: Figures are not optimally displayed in Firefo

    Distributed Approximation Algorithms for Weighted Shortest Paths

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    A distributed network is modeled by a graph having nn nodes (processors) and diameter DD. We study the time complexity of approximating {\em weighted} (undirected) shortest paths on distributed networks with a O(logn)O(\log n) {\em bandwidth restriction} on edges (the standard synchronous \congest model). The question whether approximation algorithms help speed up the shortest paths (more precisely distance computation) was raised since at least 2004 by Elkin (SIGACT News 2004). The unweighted case of this problem is well-understood while its weighted counterpart is fundamental problem in the area of distributed approximation algorithms and remains widely open. We present new algorithms for computing both single-source shortest paths (\sssp) and all-pairs shortest paths (\apsp) in the weighted case. Our main result is an algorithm for \sssp. Previous results are the classic O(n)O(n)-time Bellman-Ford algorithm and an O~(n1/2+1/2k+D)\tilde O(n^{1/2+1/2k}+D)-time (8klog(k+1)1)(8k\lceil \log (k+1) \rceil -1)-approximation algorithm, for any integer k1k\geq 1, which follows from the result of Lenzen and Patt-Shamir (STOC 2013). (Note that Lenzen and Patt-Shamir in fact solve a harder problem, and we use O~()\tilde O(\cdot) to hide the O(\poly\log n) term.) We present an O~(n1/2D1/4+D)\tilde O(n^{1/2}D^{1/4}+D)-time (1+o(1))(1+o(1))-approximation algorithm for \sssp. This algorithm is {\em sublinear-time} as long as DD is sublinear, thus yielding a sublinear-time algorithm with almost optimal solution. When DD is small, our running time matches the lower bound of Ω~(n1/2+D)\tilde \Omega(n^{1/2}+D) by Das Sarma et al. (SICOMP 2012), which holds even when D=Θ(logn)D=\Theta(\log n), up to a \poly\log n factor.Comment: Full version of STOC 201

    Isolation of Nuclei from Physarum flavicomum: Demonstration of Nuclear Cyclic Acid AMP Phosphodiesterase

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    Cyclic AMP phosphodiesterase activity in the nucleus of the myxomycete Physarum flavicomum was demonstrated by cytochemical staining utilizing electron microscopy and by enzymatic assays with tritiated cyclic AMP as the substrate. Cytochemical staining showed Physarum\u27s plasmodial phosphodiesterase activity to be located in the nucleus, along the plasma membrane, in vesicles, and free in the cytoplasm. Nuclear phosphodiesterase, which may be cell cycle dependent, was primarily located in the nucleolus. Nuclei from three to five day old microplasmodial cultures were isolated by the method of Henney and Yee. Whole cells were collected through centrifugation and washed. Pellets were homogenized in a medium composed of 0.01 MTris-HC1 (pH 7.2 at 4 °C), 0.25 M sucrose, 0.01% Triton X-100, and 5mM CaC1₂. Nuclei were collected through double filtration and two 1.0 M sucrose density gradient centrifugations. After the nuclei were washed, microscopic examination revealed a purity of over 90%. Radioactive assays of the nuclear preparations demonstrated phosphodiesterase activity consistant with that indicated by cytochemical localization. The specific activity of the nuclear enzyme was 15 nMole of cyclic AMP hydrolyzed /min/mg. of protein

    Impact of the Spruce Budworm (Lepidoptera: Tortricidae) on the Ottawa and Hiawatha National Forests, 1978-1980

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    The Michigan Impact Plot System was established during 1978 and 1979 to obtain a data base for quantifying the impact of the spruce budworm in the Ottawa and Hiawatha National Forests. The formulae used to estimate the mean, total, and associated standard errors of the various parameters at the national forest and forest district levels are presented. We present the 1978, 1979, and 1980 impact data for the following parameters; percent mortality, total dead volume. dead volume per ha, live volume per ha, defoliation ranking, frequency and extent of top-kill, and incidence of spruce budworm feeding on saplings and regenera- tion. Statistics from an annual inventory of 108 composite ground sampling units (CGSU) in 1978, and 136 CGSU\u27s in 1979 and 1980 provide a more precise estimate ofthe impact of the spruce budworm in Michigan\u27s Upper Peninsula than ha~ been available to date

    Self-pulsation dynamics in narrow stripe semiconductor lasers

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    In this paper, we address the physical origin of self-pulsation in narrow stripe edge emitting semiconductor lasers. We present both experimental time-averaged polarization-resolved near-field measurements performed with a charged-coupled device camera and picosecond time resolved near-field measurements performed with a streak camera. These results demonstrate dynamic spatial-hole burning during pulse formation and evolution. We conclude from these experimental results that the dominant process which drives the self-pulsation in this type of laser diode is carrier induced effective refractive index change induced by the spatial-hole burning

    Submicrosecond comparisons of time standards via the Navigation Technology Satellites (NTS)

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    An interim demonstration was performed of the time transfer capability of the NAVSTAR GPS system using a single NTS satellite. Measurements of time difference (pseudo-range) are made from the NTS tracking network and at the participating observatories. The NTS network measurements are used to compute the NTS orbit trajectory. The central NTS tracking station has a time link to the Naval Observatory UTC (USNO,MC1) master clock. Measurements are used with the NTS receiver at the remote observatory, the time transfer value UTC (USNO,MC1)-UTC (REMOTE, VIA NTS) is calculated. Intercomparisons were computed using predicted values of satellite clock offset and ephemeus

    Starlings. Wildlife Damage Management Series

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