51 research outputs found
Phantastes Chapter 15: Campaspe
Get PDFCampaspe, an Elizabethan play by John Lyly (1584). The lines quoted are from Act 3, Scene 4, and they indicate the notion of a Platonic beauty, an ideal beauty that the artist can never capture perfectl
Alexander and Campaspe
Get PDFThe programme was scanned from an original held in the University Archives.This play was produced under the direction of Brian Elliott and was staged at The Hut from 9 - 12 August 1950
Distinct Early Molecular Responses to Mutations Causing vLINCL and JNCL Presage ATP Synthase Subunit C Accumulation in Cerebellar Cells
Get PDFVariant late-infantile neuronal ceroid lipofuscinosis (vLINCL), caused by CLN6 mutation, and juvenile neuronal ceroid lipofuscinosis (JNCL), caused by CLN3 mutation, share clinical and pathological features, including lysosomal accumulation of mitochondrial ATP synthase subunit c, but the unrelated CLN6 and CLN3 genes may initiate disease via similar or distinct cellular processes. To gain insight into the NCL pathways, we established murine wild-type and CbCln6nclf/nclf cerebellar cells and compared them to wild-type and CbCln3Δex7/8/Δex7/8 cerebellar cells. CbCln6nclf/nclf cells and CbCln3Δex7/8/Δex7/8 cells both displayed abnormally elongated mitochondria and reduced cellular ATP levels and, as cells aged to confluence, exhibited accumulation of subunit c protein in Lamp 1-positive organelles. However, at sub-confluence, endoplasmic reticulum PDI immunostain was decreased only in CbCln6nclf/nclf cells, while fluid-phase endocytosis and LysoTracker® labeled vesicles were decreased in both CbCln6nclf/nclf and CbCln3Δex7/8/Δex7/8 cells, though only the latter cells exhibited abnormal vesicle subcellular distribution. Furthermore, unbiased gene expression analyses revealed only partial overlap in the cerebellar cell genes and pathways that were altered by the Cln3Δex7/8 and Cln6nclf mutations. Thus, these data support the hypothesis that CLN6 and CLN3 mutations trigger distinct processes that converge on a shared pathway, which is responsible for proper subunit c protein turnover and neuronal cell survival
Sapho and Phao played beefore the Queenes Maiestie on Shroue-tewsday by Her Maiesties children and the boyes of Paules.
No full textEndimion, the man in the moone Playd before the Queenes Maiestie at Greenewich on Candlemas day at night, by the Chyldren of Paules.
No full textThe vvoman in the moone As it was presented before her Highnesse. By Iohn Lyllie maister of Artes.
No full textEuphues. The anatomy of vvyt Very pleasant for all gentlemen to reade, and most necessary to remember: wherin are contained the delights that wyt followeth in his youth, by the pleasauntnesse of loue, and the happynesse he reapeth in age, by the perfectnesse of wisedome. By Iohn Lylly Master of Arte. Oxon.
No full textGallathea As it was playde before the Queenes Maiestie at Greene-wiche, on Newyeeres day at night. By the Chyldren of Paules.
No full textEuphues and his England Containing his voyage and his aduentures, myxed with sundrie pretie discourses of honest loue, the discription of the countrey, the court, and the manners of that isle. Delightful to be read, and nothing hurtfull to be regarded: wherein there is small offence by lightnesse giuen to the wise, and lesse occasion of looseness proffered to the wanton. By Iohn Lyly, Maister of Arte. Commend it, or amend it.
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