Sp1 elements in SULT2B1b promoter and 5′-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition

AbstractThe steroid/sterol sulfotransferase gene (SULT2B1) encodes for two isozymes of which one (SULT2B1b) sulfonates cholesterol and is selectively expressed in skin. The human SULT2B1 gene contains neither a TATAAA nor a CCAAT motif upstream of the coding region for SULT2B1b; however, this area is GC-rich. Of five Sp1 elements identified two had regulatory activity utilizing immortalized human keratinocytes: one element is located above the ostensible transcription initiation site, whereas the other is located within the 5′-untranslated region of the SULT2B1b mRNA. Sp1 and Sp2 transcription factors identified by supershift analyses induced reporter gene activity, an effect markedly augmented by histone deacetylase inhibition

Optical pulse Self-compressor combined the Nonlinear coupler with Backward Raman fiber amplifier

Based on the nonlinearity of the nonlinear optical coupler (NOC) and the amplifying capacity of the backward Raman fiber amplifier (PBRFA), a new optical system to compress the optical pulse (optical pulse self-compressor: OPSC) is proposed. Using the expressions describing relationship between output intensities from both output ports and input one of NOC and the expression describing the amplification of the PBRFA, the compressing process of the optical pulse propagating through OPSC is simulated. The results show that the peak of optical pulse will be enhanced and the duration of optical pulse will be reduced significantly, and the shape of input pulse is completely compressed with certain efficiency. It means the optical pulse is self-compressed without the pump pulse

INFLUENCING FACTORS TO LOGISTICS CENTRE FORMATION – A STUDY OF VIETNAM-BASED LOGISTICS SECTOR

Purpose of the study: The paper tries to model dynamic interactions of factors that contribute to the logistics center building. Conducting the desk review and expert consultation, the causality of the factors is systemized in a form of Causal Loop Diagram using the System Dynamics approach. Methodology: System Dynamics (SD) is an approach for studying interlinked behaviors within a system and reflects the interactions of feedback loops. Compared to other approaches, SD demonstrates the real world by using factors and stocks for components and feedback loops for inter-relationships among them. SD model qualitatively illustrates the causal relationship among factors that influence the building of the logistics center. Main Findings: A combination of four different sub-systems, using a questionnaire survey conducted with logistics service users and providers to sort out the high scored factors. Besides, the survey also helps to study the practical conditions and characteristics in showing the demand, the trend, and the development of logistics centers in Vietnam. Applications of this study: Logistics centers (LCs) can be considered as a depot for vehicles where drivers and managers of vehicles are supposed to maintain, repair vehicles, and adjust vehicle operation schedules. Novelty/Originality of this study: As defined by the scope of the project, the SD model provides a qualitative demonstration of the interaction among factors. The built model gives a systematic insight into how factors link to each other

Making Smart Contracts Smarter

Cryptocurrencies record transactions in a decentralized data structure called a blockchain. Two of the most popular cryptocurrencies, Bitcoin and Ethereum, support the feature to encode rules or scripts for processing transactions. This feature has evolved to give practical shape to the ideas of smart contracts, or full-fledged programs that are run on blockchains. Recently, Ethereum\u27s smart contract system has seen steady adoption, supporting tens of thousands of contracts, holding millions dollars worth of virtual coins. In this paper, we investigate the security of running smart contracts based on Ethereum in an open distributed network like those of cryptocurrencies. We introduce several new security problems in which an adversary can manipulate smart contract execution to gain profit. These bugs suggest subtle gaps in the understanding of the distributed semantics of the underlying platform. As a refinement, we propose ways to enhance the operational semantics of Ethereum to make contracts less vulnerable. For developers writing contracts for the existing Ethereum system, we build a symbolic execution tool called Oyente to find potential security bugs. Among 19, 336 existing Ethereum contracts, Oyente flags 8, 833 of them as vulnerable, including the TheDAO bug which led to a 60 million US dollar loss in June 2016. We also discuss the severity of other attacks for several case studies which have source code available and confirm the attacks (which target only our accounts) in the main Ethereum network

HMU fluorinze mouthwash enhances enamel remineralization: An in vitro study

BACKGROUND: Fluoride therapy has long been used extensively to prevent dental caries. Fluoride appears in variety of dental care products such as mouthrinse, dentifrice, gel, etc. HMU fluorinze is the first mouthwash containing fluoride in Vietnam. AIM: This research was conducted to evaluate the efficacy of HMU Fluorinze mouthwash on remineralizing enamel in laboratory conditions. METHODS: 20 third molars teeth were cleaned and covered with nail polish , except for a 3x3 mm square on their buccal surfaces. These teeth went through two steps: demineralization using Coke and remineralization for 20 days: 1) using standard calcifying solution (control group) and 2) using standard calcifying solution + HMU Fluorinze mouthwash 2 times/day (experimental group). The mineralization index of enamel structure after demineralization and remineralization was assessed by DIAGNOdent pen 2190. RESULTS: The mineralization indexes of the control group and experimental group at baseline were 3.65 ± 0.76 and 3.35 ± 0.64, after demineralization were in turn of 21.78 ± 4.48 and 20.25 ± 2.26; and after remineralization were 6.30 ± 1.03 and 3.90 ± 1.24. The different figures  between the two groups after remineralization shows statistical significance (p<0.01). Group B using HMU fluorinze mouthwash after 20 days did not differ from the original results (p = 0.272), in contrast with the control group (p<0.01). CONCLUSIONS: HMU fluorinze mouthwash has better mineralization effect than standard calcifying solution

Household Savings in Vietnam: Insights from a 2006 Rural Household Survey

The aim of this paper is to inform the reader about the rural households' saving situation in Vietnam and the determinants of household saving with special interest in the possible effects of network savings behavior on household savings behavior. In Vietnam households hold capital through informal means. This means prevents it in many cases from being used effectively for investment purposes. Disseminating information about the merits of institutional saving could potentially stimulate formal household savings making. We discuss the extent to which social networks may act as an effective information transmission mechanism, and also argue that the nature and quality of the information disseminated must be carefully considered to expect the desired policy response

Research on Hydrochemical Characters and Water Qtlality in the Coastal Region from Quangninh to Haiphong

Abstracts of 3rd UNU-ORI joint international workshop for marine environment海洋環境国際ワークショップ講演要

Neuromuscular Blockade Agents Reversal with Sugammadex Compared to Neostigmine in the Living Kidney Donors

Backround: The reversation of NMBA (neuromuscular blocking agents) prevents numerous postoperative complications, increases quality of recovery and decreases the time, expenditure spending in hospital. The choice of medicine used to reverse NMBA depends  considered as a key fators to gain the best outcome and to avoid the side effects. Aim: To evaluate the postoperative effect on muscle relaxation reversal and side effects of sugammadex 2 mg/kg versus the combination of  neostigmine and atropine sulfate in the living kidney donors. MethodS: A randomised controlled trial on 70 patients undergoing living kidney donation surgery were allocated to 2 groups. Patients in group I (SUGA) were reversed with sugammadex 2 mg/kg and in group II (NEO/ATR) with the combination of neostigmine and atropine sulfat. Results: With 35 patients in each group, the study results showed that after 3 mintutes of reversal patients reaching TOF value ≥ 0.9 in group SUGA is 91.4%, after 5 minutes 100% of patients in group SUGA reached TOF value ≥ 0.9 . In group NEO/ATR after 3 minutes 28.6% patients reached TOF ≥ 0.9 and 40% patients reached TOF≥ 0.9 after 5 minutes. The difference in percentage of patients reaching TOF ≥ 0.9 after 3 minutes, 5 minutes of reversal between two groups is significant (p<0.05). After 10 minutes, 100% patients in both group got TOF ≥ 0.9. Time to exutubation of group SUGA was 249.43 ± 81.75 seconds and it was 456.29 ± 146.45 seconds in group NEO/ATR. Nausea, bradycardia, and increased phlegm production in group NEO/ATR was 22.9%; 28.5%; 25.7% respectively; while those side effects were not met in group SUGA, the difference was significant (p<0.05). Conclusion: The muscle relaxation reversal effect of sugammadex was faster than that of neostigmine, the duration TOF ≥ 0.9 and the time to extubation was significantly faster. Sugammadex did not cause hemodynamic changes before and after muscle relaxation reversal, neostigmine resulted in the bradycardia, increased phlegm secreting and other side effects. The renal function after 24 hours postoperatively of two groups was similar

Direct Observation of Exceptional Points in Photonic Crystal by Cross-Polarization Imaging in Momentum Space

This study explores exceptional points (EPs) in photonic crystals (PhCs) and introduces a novel method for their single-shot observation. Exceptional points are spectral singularities found in non-Hermitian systems, such as leaky PhC slabs. However, directly observing EPs in PhC systems using regular reflectivity spectroscopy is a considerable challenge due to interference between guided resonances and background signals. In this work, we present a simple, nondestructive technique that employs crossed polarizations to directly observe EPs in momentum-resolved resonant scattering. This approach effectively suppresses the background signal, enabling exclusive probing of the guided resonances where EPs manifest. Our results demonstrate the formation of EPs in both energy-momentum mapping and isofrequency imaging. All experimental findings align seamlessly with numerical simulations and analytical models. Our approach holds great potential as a robust tool for studying non-Hermitian physics in PhC platform