A comprehensive integrated drug similarity resource for in-silico drug repositioning and beyond.

Drug similarity studies are driven by the hypothesis that similar drugs should display similar therapeutic actions and thus can potentially treat a similar constellation of diseases. Drug-drug similarity has been derived by variety of direct and indirect sources of evidence and frequently shown high predictive power in discovering validated repositioning candidates as well as other in-silico drug development applications. Yet, existing resources either have limited coverage or rely on an individual source of evidence, overlooking the wealth and diversity of drug-related data sources. Hence, there has been an unmet need for a comprehensive resource integrating diverse drug-related information to derive multi-evidenced drug-drug similarities. We addressed this resource gap by compiling heterogenous information for an exhaustive set of small-molecule drugs (total of 10 367 in the current version) and systematically integrated multiple sources of evidence to derive a multi-modal drug-drug similarity network. The resulting database, 'DrugSimDB' currently includes 238 635 drug pairs with significant aggregated similarity, complemented with an interactive user-friendly web interface (http://vafaeelab.com/drugSimDB.html), which not only enables database ease of access, search, filtration and export, but also provides a variety of complementary information on queried drugs and interactions. The integration approach can flexibly incorporate further drug information into the similarity network, providing an easily extendable platform. The database compilation and construction source-code has been well-documented and semi-automated for any-time upgrade to account for new drugs and up-to-date drug information

Milionella subrotunda (Montague 1803), a miliolid foraminifer building large agglutinated tubes for a temporary epibenthic livestyle.

Live observations, cytological characteristics and biometrical measurements on Miliolinella subrotunda (Montagu, 1803) sampled from the northern and southern Atlantic Ocean are presented.M. subrotunda facultatively constructs a long, detritic tube lifting the test several millimeters above the sediment surface. A thickened conical base anchors the construction on the sediment surface and a long, flexible tube protrudes into the velocity profile of the bottom currents. The miliolid test is placed on top, surrounded by the uppermost part of the tube. This construction allows the organisms to feed in the particle stream above the sediment surface. In comparison to species living in and on the surface sediments,M. subrotunda apparently shows higher nutritional values in food ingested and larger amounts of reserve substances. Characteristics of the shape and structure that reduce drag on the tubes include a broadened conical base, a flexible tube, and a rounded top. From biometrical measurements it is concluded, that the tubes are constructed over a short period of their ontogeny

Final Report - Effects of High Spinel and Chromium Oxide Crystal Contents on Simulated HLW Vitrification in DM100 Melter Tests, VSL-09R1520-1, Rev. 0, dated 6/22/09

The principal objective of the work was to evaluate the effects of spinel and chromium oxide particles on WTP HLW melter operations and potential impacts on melter life. This was accomplished through a combination of crucible-scale tests, settling and rheological tests, and tests on the DM100 melter system. Crucible testing was designed to develop and identify HLW glass compositions with high waste loadings that exhibit formation of crystalline spinel and/or chromium oxide phases up to relatively high crystal contents (i.e., > 1 vol%). Characterization of crystal settling and the effects on melt rheology was performed on the HLW glass formulations. Appropriate candidate HLW glass formulations were selected, based on characterization results, to support subsequent melter tests. In the present work, crucible melts were formulated that exhibit up to about 4.4 vol% crystallization

FINAL REPORT INTEGRATED DM1200 MELTER TESTING OF BUBBLER CONFIGURATIONS USING HLW AZ-101 SIMULANTS VSL-04R4800-4 REV 0 10/5/04

This report documents melter and off-gas performance results obtained on the DM1200 HLW Pilot Melter during processing of AZ-101 HLW simulants. The tests reported herein are a subset of six tests from a larger series of tests described in the Test Plan for the work; results from the other tests have been reported separately. The solids contents of the melter feeds were based on the WTP baseline value for the solids content of the feeds from pretreatment which changed during these tests from 20% to 15% undissolved solids resulting in tests conducted at two feed solids contents. Based on the results of earlier tests with single outlet 'J' bubblers, initial tests were performed with a total bubbling rate of 651 pm. The first set of tests (Tests 1A-1E) addressed the effects of skewing this total air flow rate back and forth between the two installed bubblers in comparison to a fixed equal division of flow between them. The second set of tests (2A-2D) addressed the effects of bubbler depth. Subsequently, as the location, type and number of bubbling outlets were varied, the optimum bubbling rate for each was determined. A third (3A-3C) and fourth (8A-8C) set of tests evaluated the effects of alternative bubbler designs with two gas outlets per bubbler instead of one by placing four bubblers in positions simulating multiple-outlet bubblers. Data from the simulated multiple outlet bubblers were used to design bubblers with two outlets for an additional set of tests (9A-9C). Test 9 was also used to determine the effect of small sugar additions to the feed on ruthenium volatility. Another set of tests (10A-10D) evaluated the effects on production rate of spiking the feed with chloride and sulfate. Variables held constant to the extent possible included melt temperature, plenum temperature, cold cap coverage, the waste simulant composition, and the target glass composition. The feed rate was increased to the point that a constant, essentially complete, cold cap was achieved, which was used as an indicator of a maximized feed rate for each test. The first day of each test was used to build the cold cap and decrease the plenum temperature. The remainder of each test was split into two- to six-day segments, each with a different bubbling rate, bubbler orientation, or feed concentration of chloride and sulfur

Increased risk of venous thromboembolism in patients with acute leukaemia

Patients with malignancies have an increased risk for venous thromboembolisms (VTE), but data on patients with acute leukaemia are very limited so far. We found VTE in 12% of 455 patients with acute leukaemia, half of which occurred in association with central venous catheters, with equal risk of ALL and AML

Soldiering On? The Prison‐Military Complex and Ex‐Military Personnel as Prison Officers: Transition, Rehabilitation and Prison Reform

Arguing that criminology has thus far inadequately theorised militarism as it relates to the prison system, this agenda-setting article introduces the ‘prison-military complex’ as a means to initiate examination of militarism in relation to institutions and practices of incarceration. In so doing, it identifies a key knowledge gap vis-à-vis the role of ex-military personnel employed as prison staff; and poses key questions about the ways in which military staff and military methods are being directly targeted as a means to reform a prison service reeling from unprecedented levels of violence, self-harm, riots, and escapes. Encouraging criminologists to think beyond stereotypical ideas about the military, the article revolves around a multiscalar articulation of the prison-military complex, discussed here as it relates to reform of the prison system as a whole; the rehabilitation of offenders; and individuals’ ex-military transitions to civilian life

Sur les solutions périodiques du mouvement plan de libration des satellites et des planètes

Ce papier présente une étude analytique du mouvement plan de rotation des satellites (et des planètes) dans leurs mouvements orbitaux. Les trois familles des solution périodiques sont obtenues par la méthode du prolongement analytique de Poincaré. Ensuite, la stabilité de ces solutions périodiques est discutée, et les équations approchées des courbes limites de stabilité sont données jusqu'au quatrième ordre. This paper presents an analytical study of the rotational motion of the satellites (and the planets) in their orbital planes. The three families of periodic solutions are obtained by the method of analytical continuation as formulated by Poincaré. The stability of these solutions are analyzed, and the approximate equations of the transition curves are obtained to the fourth order.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42563/1/10569_2005_Article_BF01227807.pd