Observations of long period waves in the tropical oceans and atmosphere

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Woods Hole Oceanographic Institution February 1980The existence of resonant, baroclinic, equatorially-trapped inertia-gravity waves (discovered by Wunsch and Gill (1976)) is confirmed in the mid-Pacific by spectral analysis of long sea level records. The energy of the low-mode inertia-gravity waves is found to decrease toward the meridional boundaries. A simple spectral model, acknowledging the dispersive characteristics of the equatorial waves, adequately reproduces the observed mid-Pacific sea level spectra in the 1-6 day band. Model spectra computed at latitudes outside the equatorial waveguide of the gravest meridional modes suggest the presence of "inertial" peaks in several observed sea level spectra. Resonant, low-mode inertia-gravity waves may also exist in the Indian Ocean. Sea level fluctuations along the Pacific equator are found to have Kelvin wave characteristics in the 35-80 day band, and, in particular, propagation from the western Pacific to the coast of South America is observed. The Kelvin waves are atmospherically-forced in the central- western Pacific and have a computed equivalent depth corresponding to the first-baroc1inic mode. Outside of the equatorial mid-Pacific, a non-static ocean response to air pressure in the 4-6 day band is dominated by a basin-wide, barotropic, planetary mode. The low Q of this mode suggests that the ocean is viscous with respect to large-scale barotropic oscillations. The dynamical components of the observed long-period tides have been isolated for the first time using the "self-consistent" equilibrium tide of Agnew and Farrell (1978). The tides are slightly non-equilibrium with large horizontal scales. The relatively short-scale Rossby modes predicted by Wunsch (1967) are not observed, perhaps because of the poor spatial coverage of the dataset. Considering the low Q of the 4-6 day planetary basin mode, it is suggested that the long-period tides are frictionally-controlled. The 4- and 5-day equatorial inertia-gravity waves, the 35-80 day Kelvin waves and the 4-6 day planetary basin mode are clearly atmospherically forced, and, perhaps surprisingly, they are forced by atmospheric waves that have similar horizontal structures, i.e., 4-5 day Rossby-gravity waves, 40-50 day Kelvin waves and a 5-day global barotropic mode. The surface expressions of these atmospheric waves are determined in order to understand the nature of the oceanic response, e.g., resonant or forced. Much of the information about the surface atmospheric fields that has been collected, including frequency-wavenumber descriptions, awaits an accurate model of the coupling between wind stress and internal ocean waves.Monetary support for this research was provided by the National Science Foundation through contract OCE73-0l384. At various times, tuition and living expenses were paid by funds from the NSF contract above, the Office of Naval Research (contract N00014-C-75-029l), the Cecil and Ida Green Professorship in Earth Sciences, the J. P. Luther Educational Fund and by an M.I.T. Educational Tuition Award

High-Q spectral peaks and nonstationarity in the deep ocean infragravity wave band: Tidal harmonics and solar normal modes

Author Posting. © American Geophysical Union, 2019. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans 124(3), (2019):2072-2087, doi:10.1029/2018JC014586.Infragravity waves have received the least study of any class of waves in the deep ocean. This paper analyzes a 389‐day‐long deep ocean pressure record from the Hawaii Ocean Mixing Experiment for the presence of narrowband (≲2 μHz) components and nonstationarity over 400–4,000 μHz using a combination of fitting a mixture noncentral/central χ2 model to spectral estimates, high‐resolution multitaper spectral estimation, and computation of the offset coherence between distinct frequencies for a given data segment. In the frequency band 400–1,000 μHz there is a noncentral fraction of 0.67 ± 0.07 that decreases with increasing frequency. Evidence is presented for the presence of tidal harmonics in the data over the 400‐ to 1,400‐μHz bands. Above ~2,000 μHz the noncentral fraction rises with frequency, comprising about one third of the spectral estimates over 3,000–4,000 μHz. The power spectrum exhibits frequent narrowband peaks at 6–11 standard deviations above the noise level. The widths of the peaks correspond to a Q of at least 1,000, vastly exceeding that of any oceanic or atmospheric process. The offset coherence shows that the spectral peaks have substantial (p = 0.99–0.9999) interfrequency correlation, both locally and between distinct peaks within a given analysis band. Many of the peak frequencies correspond to the known values for solar pressure modes that have previously been observed in solar wind and terrestrial data, while others are the result of nonstationarity that distributes power across frequency. Overall, this paper documents the existence of two previously unrecognized sources of infragravity wave variability in the deep ocean.This work was supported at WHOI by an Independent Research and Development award and the Walter A. and Hope Noyes Smith Chair for Excellence in Oceanography. At the University of Hawaii, Martin Guiles provided a number of consequential data analyses, and work was supported by NSF‐OCE1460022. D. J. T. acknowledges support from Queen's University and NSERC. The data used in this study are available from the supporting information.2019-08-2

Forecasts of Wave-Induced Coastal Hazards in the United States Pacific Islands: Past, Present, and the Future

This paper summarizes the existing coastal hazard forecast methods of PacIOOS, such as wave-induced run-up, by focusing on the critical components that need to be addressed in order to improve these forecasts and make them more accurate and available to broader coastal communities. We then propose that a horizontally, two-dimensional numerical modeling approach method should be adopted for developing future wave-induced coastal forecasts. To reach a future in which real-time two-dimensional model-based forecasts are a reality, we identify existing technologies that could lead to improvements, such as: (i) more accurate, accessible and frequently updated bathymetry and topography datasets; (ii) increased computational and software capabilities; and, (iii) more accurate sea level datasets. These advances, combined with crowdsourced-based model-data validation, will result in faster and more accurate forecasting tools that could greatly benefit coastal communities in need of more efficient risk mitigation programs

The Cascadia Initiative : a sea change In seismological studies of subduction zones

Author Posting. © The Oceanography Society, 2014. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 27, no. 2 (2014): 138-150, doi:10.5670/oceanog.2014.49.Increasing public awareness that the Cascadia subduction zone in the Pacific Northwest is capable of great earthquakes (magnitude 9 and greater) motivates the Cascadia Initiative, an ambitious onshore/offshore seismic and geodetic experiment that takes advantage of an amphibious array to study questions ranging from megathrust earthquakes, to volcanic arc structure, to the formation, deformation and hydration of the Juan De Fuca and Gorda Plates. Here, we provide an overview of the Cascadia Initiative, including its primary science objectives, its experimental design and implementation, and a preview of how the resulting data are being used by a diverse and growing scientific community. The Cascadia Initiative also exemplifies how new technology and community-based experiments are opening up frontiers for marine science. The new technology—shielded ocean bottom seismometers—is allowing more routine investigation of the source zone of megathrust earthquakes, which almost exclusively lies offshore and in shallow water. The Cascadia Initiative offers opportunities and accompanying challenges to a rapidly expanding community of those who use ocean bottom seismic data.The Cascadia Initiative is supported by the National Science Foundation; the CIET is supported under grants OCE- 1139701, OCE-1238023, OCE‐1342503, OCE-1407821, and OCE-1427663 to the University of Oregon

A phase I study of CPI-613 (devimistat) in combination with chemoradiation in patients with pancreatic adenocarcinoma

Background: Local tumor progression is a cause of significant mortality and morbidity in patients with unresectable pancreatic ductal adenocarcinoma (PDAC). Effective approaches to achieve durable local control are urgently needed. Metabolic reprogramming and enhanced mitochondrial function, both hallmarks of PDAC, are known contributors to chemo- and radio-resistance. CPI-613, a lipoic acid analog that selectively inhibits components of the Krebs cycle in tumors, showed promising preclinical synergy in combination with gemcitabine and radiation therapy (gem-RT). Methods: We describe a single-arm, single-center, open-label, phase I study designed to determine the maximumtolerated dose of CPI-613 when used concomitantly with gemcitabine and intensity modulated radiation therapy (IMRT) for local control of PDAC. CPI-613 will be administered once weekly by intravenous infusion over approximately 2 hours at a starting dose of 500 mg/m2 and dose-escalated/de-escalated using a Bayesian optimal interval design. Gemcitabine will be given once weekly at 400 mg/m2 dosage and IMRT as 54 Gray (Gy) in 30 fractions (1.8 Gy per fraction) with five fractions given per week. Up to 24 patients will be enrolled for the study after meeting the following main eligibility criteria, which include: pathologically confirmed PDAC; inoperable disease that by institutional pancreatic multidisciplinary tumor board or multidisciplinary review are considered to benefit from definitive local control of the primary tumor; ECOG of 0-2; and adequate organ and marrow function after completion of intended systemic chemotherapy. The secondary objectives are to determine the recommended phase II dose of CPI-613 when used with gem-RT, safety and tolerability of CPI-613-gem-RT, overall survival, local progression-free survival (PFS), overall PFS, patient-reported quality of life after treatment, and late gastrointestinal toxicities following treatment with CPI-613-gem-RT

A new method for estimating the turbulent heat flux at the bottom of the daily mixed layer

A new method is presented for estimating the vertical turbulent heat flux at the bottom of the daily mixed layer from the temperature data in the mixed layer and net solar irradiance data at the sea surface. We assume that fluctuations in the divergence of advective heat flux have longer than daily time scales. The method is applied to data from the eastern tropical Pacific, where the daily cycle in the temperature field is confined to the upper 10-25 m. The night-to-day difference of the turbulent heat flux calculated from the data obtained during nine daily cycles in November 1984 agrees well on average with the same quantity estimated from microstructure observations. The night-to-day difference of the turbulent heat flux, estimated at several mooring stations near the equator (an average over 100 to 300 daily cycles), varies from 120 to 220 W/m² with larger values on the equator. Equatorial turbulence measurements show that the turbulent heat flux is much larger during nighttime than daytime. Therefore the present estimates give approximately the nighttime average, which is the major part of the turbulent heat flux. From the daytime heat budget we obtain divergence of the low-frequency horizontal heat advection at 1°30’S, 140°W; it is governed by equatorial mesoscale fluctuations having a predominant period of 15-20 days

Noncommutative Fluids

We review the connection between noncommutative gauge theory, matrix models and fluid mechanical systems. The noncommutative Chern-Simons description of the quantum Hall effect and bosonization of collective fermion states are used as specific examples.Comment: To appear in "Seminaire Poincare X", Institut Henri Poincare, Paris; references adde

Reducing the Activity and Secretion of Microbial Antioxidants Enhances the Immunogenicity of BCG

BACKGROUND:In early clinical studies, the live tuberculosis vaccine Mycobacterium bovis BCG exhibited 80% protective efficacy against pulmonary tuberculosis (TB). Although BCG still exhibits reliable protection against TB meningitis and miliary TB in early childhood it has become less reliable in protecting against pulmonary TB. During decades of in vitro cultivation BCG not only lost some genes due to deletions of regions of the chromosome but also underwent gene duplication and other mutations resulting in increased antioxidant production. METHODOLOGY/PRINCIPAL FINDINGS:To determine whether microbial antioxidants influence vaccine immunogenicity, we eliminated duplicated alleles encoding the oxidative stress sigma factor SigH in BCG Tice and reduced the activity and secretion of iron co-factored superoxide dismutase. We then used assays of gene expression and flow cytometry with intracellular cytokine staining to compare BCG-specific immune responses in mice after vaccination with BCG Tice or the modified BCG vaccine. Compared to BCG, the modified vaccine induced greater IL-12p40, RANTES, and IL-21 mRNA in the spleens of mice at three days post-immunization, more cytokine-producing CD8+ lymphocytes at the peak of the primary immune response, and more IL-2-producing CD4+ lymphocytes during the memory phase. The modified vaccine also induced stronger secondary CD4+ lymphocyte responses and greater clearance of challenge bacilli. CONCLUSIONS/SIGNIFICANCE:We conclude that antioxidants produced by BCG suppress host immune responses. These findings challenge the hypothesis that the failure of extensively cultivated BCG vaccines to prevent pulmonary tuberculosis is due to over-attenuation and suggest instead a new model in which BCG evolved to produce more immunity-suppressing antioxidants. By targeting these antioxidants it may be possible to restore BCG's ability to protect against pulmonary TB

The Cascadia Initiative: A Sea Change In Seismological Studies of Subduction Zones

Increasing public awareness that the Cascadia subduction zone in the Pacific Northwest is capable of great earthquakes (magnitude 9 and greater) motivates the Cascadia Initiative, an ambitious onshore/offshore seismic and geodetic experiment that takes advantage of an amphibious array to study questions ranging from megathrust earthquakes, to volcanic arc structure, to the formation, deformation and hydration of the Juan De Fuca and Gorda Plates. Here, we provide an overview of the Cascadia Initiative, including its primary science objectives, its experimental design and implementation, and a preview of how the resulting data are being used by a diverse and growing scientific community. The Cascadia Initiative also exemplifies how new technology and community-based experiments are opening up frontiers for marine science. The new technology—shielded ocean bottom seismometers—is allowing more routine investigation of the source zone of megathrust earthquakes, which almost exclusively lies offshore and in shallow water. The Cascadia Initiative offers opportunities and accompanying challenges to a rapidly expanding community of those who use ocean bottom seismic data.This is the publisher’s final pdf. The published article is copyrighted by the Oceanography Society and can be found at: http://www.tos.org/oceanography/index.html