Emergent multimedia clusters in the Lille, Lyon and Marseille metropolitan areas

The spatial, organizational and institutional proximity plays an important part in the geography of economic development (Boschma, 2005). It is therefore important to see what kinds of networks are being developed within the multimédia sector between the different actors of the Triple Helix (Etzkowitz and Leydersdorff, 1997): firms, training and R&D facilities, and public authorities. We will take for the example three French metropolitan areas: Lille, Lyon and Marseille. The dynamism of the social networks is supported by the development of a collective governance which associates public and private actors (Maillat and Kébir, 1999). So, initiatives have launched to facilitate strategic governance of emergent regional multimédia clusters. Three forms of governance (Tremblay and Rousseau, 2005) can be distinguished: public (Pole Images Nord-Pas-de-Calais in Lille), private (Imaginove in Lyon) and public-private partnership (Pole Sud Image in Marseille). These contrasted situations result from internal conflicts in the different industries of the multimedia sector. These structures have launched several similar actions in order to the constitution of social networks. Principles are inspired by the Competitivness Clusters and Michael Porter’s theories (2000). We can summarize them in the following way: - Interprofessional meetings, - Pooling of the human resources of the companies from the cluster, - Training programme for employees and executives, - Calls for collaborative projects which associate industrial and academic partners, - Support to firms willing to try out innovative business approaches, - Support programme for companies seeking to compete internationally. But, collaboration between different firms was generally low or nonexistent in spite of several regional projects (Einright, 1996). Collaborations are still very recent, rarely include a cross-media approach and hesitate to develop partnerships with research units. Similarly, the three metropolitan areas suffer from the poor adaptation of the regional training offer, which is far too rich and diverse compared to the actual capacities of the regional moving picture economy. Companies, mainly SMEs, cannot hire many people and they hesitate to embark on international missions.

Creativity in the Lille metropolitan area : the example of the image sector

In France, the Paris region is the traditional centre for decision-making and creative functions. Unsurprisingly, it concentrates most cultural industries – cinema, multimedia, TV, etc. The aim of this paper is to study how other French cities, and more specifically regional medium-sized cities, can develop this type of activities. We will take the example of the multimedia industry in the Lille metropolitan area. Ann-Lee Saxenian (1994) has shown the importance of regional culture and heritage in the constitution of an economic trajectory. The pre-existence of links between film production, media or microelectronic industries, and of an intense cultural life can support the emergence of essential know-how for the development of an image sector (Sträter, 2000). Lille isn’t a traditional filming area and the weak presence of the television media didn’t facilitate the emergence of large regional production groups. But, the decline of textile factories has allowed the development of new activities, as mail-order selling, which have used multimedia and image technologies since the 1980s. Moreover, Lille metropolitan area has a broad training offering in the technical and creative fields which can have significant repercussions for the constitution of a creative class (Florida, 2002). But the emergence of start-up has been very limited since the 1990s and 2000s. In 2009, the Lille metropolitan area counts only 350 firms in the image sector and has not a critical mass. Cognitive diversity generated by a social group stimulates creative individual potential (Miliken, Bartel and Kurtzberg, 2003). This explains the choice made by public authorities to locate audiovisual and multimedia firms in three media districts, which accommodates schools, research centres, publics authorities and firms (thanks to free tax zones, cheap facilities and incubators) according to the Triple Helix principles (Etzkowitz and Leydersdorff, 1997). That projects aim to retain young graduates by offering an environment enable to developing their careers. But the national project for extending the Plaine Saint-Denis audiovisual cluster, located north of Paris, is likely to deter the settlement of firms in Lille, because of the weakness of both the sector and the networks.

Chemokines and Viruses: The Dearest Enemies

AbstractThe relation between viruses and the chemokine system is characterized by a complex blend of enmity and attraction. Chemokines are key regulators of innate and adaptive immune responses against invading microorganisms, including viruses. They act not only as immune system “traffic officers,” controlling leukocyte migration under both physiological and pathological conditions, but also as fine orchestrators that modulate the induction, amplification, and cytokine-secretion pattern of antiviral responses. However, viruses have succeeded in turning the chemokine system into an ally. During the course of a long parallel evolution, viruses have captured from their hosts the genetic information for encoding chemokines and chemokine receptors and have reprogrammed it for evading the control of the immune system. Moreover, selected viral agents, most notably primate immunodeficiency retroviruses, have adopted chemokine receptors as essential gateways for entry into their target cells. The endogenous secretion of chemokines is thus emerging as an important in vivo mechanism of viral control, which is potentially inducible by effective vaccines. The deepening knowledge of the interactions between viruses and chemokines may lead to novel therapeutic and preventive strategies for the control of viral and inflammatory diseases

The physical relation between disc and coronal emission in quasars.

We propose a modified version of the observed non-linear relation between the X-ray (2 keV) and the ultraviolet (2,500 Å) emission in quasars (i.e., LX∝LγUV) which involves the full width at half-maximum, FWHM, of the broad emission line, i.e., LX∝LγˆUV FWHMβˆ. By analyzing a sample of 550 optically selected non-jetted quasars in the redshift range of 0.36–2.23 from the Sloan Digital Sky Survey cross matched with the XMM-Newton catalog 3XMM-DR6, we found that the additional dependence of the observed LX − LUV correlation on the FWHM of the MgII broad emission line is statistically significant. Our statistical analysis leads to a much tighter relation with respect to the one neglecting FWHM, and it does not evolve with redshift. We interpret this new relation within an accretion disc corona scenario where reconnection and magnetic loops above the accretion disc can account for the production of the primary X-ray radiation. For a broad line region size depending on the disc luminosity as Rblr∝L0.5disc, we find that LX∝L4/7UV FWHM4/7, which is in very good agreement with the observed correlation

A Hubble diagram for quasars

We present a new method to test the ΛCDM cosmological model and to estimate cosmological parameters based on the nonlinear relation between the ultraviolet and X-ray luminosities of quasars. We built a data set of 1138 quasars by merging several samples from the literature with X-ray measurements at 2 keV and SDSS photometry, which was used to estimate the extinction-corrected 2500 Å flux. We obtained three main results: (1) we checked the nonlinear relation between X-ray and UV luminosities in small redshift bins up to z ~ 6, confirming that the relation holds at all redshifts with the same slope; (2) we built a Hubble diagram for quasars up to z ~ 6, which is well matched to that of supernovae in the common z = 0–1.4 redshift interval and extends the test of the cosmological model up to z ~ 6; and (3) we showed that this nonlinear relation is a powerful tool for estimating cosmological parameters. Using the present data and assuming a ΛCDM model, we obtain WM = 0.22 0.08 0.10 - + and WL = 0.92 0.30 0.18 - + (WM = 0.28 ± 0.04 and WL = 0.73 0.08 from a joint quasar-SNe fit). Much more precise measurements will be achieved with future surveys. A few thousand SDSS quasars already have serendipitous X-ray observations from Chandra or XMM-Newton, and at least 100,000 quasars with UV and X-ray data will be made available by the extended ROentgen Survey with an Imaging Telescope Array all-sky survey in a few years. The Euclid, Large Synoptic Survey Telescope, and Advanced Telescope for High ENergy Astrophysics surveys will further increase the sample size to at least several hundred thousand. Our simulations show that these samples will provide tight constraints on the cosmological parameters and will allow us to test for possible deviations from the standard model with higher precision than is possible today

Host-Derived Signals for Inducing Isoprenoid Gene Expression and Uses Thereof

Disclosed is a method for preparing a composition that is capable of activating the expression of a gene involved in the synthesis of an isoprenoid, the method involving: (a) contacting a plant cell with an elicitor under conditions that allow an elicitor-induced release of a compound that activates the synthesis of an isoprenoid; and (b) recovering a composition including the compound, wherein the compound is diffusible and has a molecular weight less than or equal to 10,000 daltons. Also disclosed is a substantially pure elicitor-induced composition, the composition being capable of activating a gene involved in the synthesis of a plant isoprenoid