4 research outputs found
HELZ2はヒトLINE-1RNAの不安定化を介してLINE-1の転移とタイプIインターフェロン応答を抑制する
No full text京都大学新制・課程博士博士(生命科学)甲第24749号生博第490号新制||生||65(附属図書館)京都大学大学院生命科学研究科統合生命科学専攻(主査)教授 石川 冬木, 教授 高田 穣, 教授 朝長 啓造学位規則第4条第1項該当Doctor of Philosophy in Life SciencesKyoto UniversityDFA
The interferon-stimulated gene product HELZ2 destabilizes human LINE-1 RNA to inhibit LINE-1 retrotransposition and the associated type I interferon response
No full textThe interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
Get PDFProteomic analyses revealed that a group of interferon-stimulated genes suppresses LINE-1 retrotransposon activities, including HELZ2, which reduces LINE-1 RNA and the associated innate immune response levels
