Ultrasound Attenuation in Sr2_2RuO4_4: an Angle-Resolved Study of the Superconducting Gap Function

We present a study of the electronic ultrasound attenuation $\alpha$ in the unconventional superconductor Sr$_2$RuO$_4$ . The power law behavior of $\alpha$ at temperatures down to $T_c/30$ clearly indicates the presence of nodes in the gap. In the normal state, we find an enormous anisotropy of $\alpha$ in the basal plane of the tetragonal structure. In the superconducting state, the temperature dependence of $\alpha$ also exhibits significant anisotropy. We discuss these results in relation to possible gap functions.Comment: 4 pages, 3 figures. Interpretation of data clarified. Accepted for publication in PR

Competing charge density waves probed by non-linear transport and noise in the second and third Landau levels

Charge density waves (CDW) in the second and third Landau levels (LL) are investigated by both non-linear electronic transport and noise. The use of a Corbino geometry ensures that only bulk properties are probed, with no contribution from edge states. Sliding transport of CDWs is revealed by narrow band noise in re-entrant quantum Hall states R2a and R2c of the second LL as well as in pinned CDWs of the third LL. Competition between various phases - stripe, pinned CDW or fractional quantum Hall liquid - in both LL are clearly revealed by combining noise data with maps of conductivity versus magnetic field and bias voltage.Comment: 7 pages, 10 figure

Enhancer alterations in cancer: a source for a cell identity crisis

Enhancers are selectively utilized to orchestrate gene expression programs that first govern pluripotency and then proceed to highly specialized programs required for the process of cellular differentiation. Whereas gene-proximal promoters are typically active across numerous cell types, distal enhancer activation is cell-type-specific and central to cell fate determination, thereby accounting for cell identity. Recent studies have highlighted the diversity of enhancer usage, cataloguing millions of such elements in the human genome. The disruption of enhancer activity, through genetic or epigenetic alterations, can impact cell-type-specific functions, resulting in a wide range of pathologies. In cancer, these alterations can promote a ‘cell identity crisis’, in which enhancers associated with oncogenes and multipotentiality are activated, while those promoting cell fate commitment are inactivated. Overall, these alterations favor an undifferentiated cellular phenotype. Here, we review the current knowledge regarding the role of enhancers in normal cell function, and discuss how genetic and epigenetic changes in enhancer elements potentiate oncogenesis. In addition, we discuss how understanding the mechanisms regulating enhancer activity can inform therapeutic opportunities in cancer cells and highlight key challenges that remain in understanding enhancer biology as it relates to oncology