Ultrasonic investigation of the Kondo semimetal CeBi

We report the elastic properties of the Kondo semimetal CeBi by resonant ultrasound spectroscopy measurements at zero magnetic field. Clear elastic softening is found in bulk modulus $C_B$ below $\sim 60$ K. Such a softening in $C_B$, in addition to the anomalous temperature dependent Poisson's ratio, is hardly attributable to multipolar response for stable localized $4f$ orbital, but can be well described by a two-band model arising from the hybridization between conduction- and $4f$- electrons. These results probably are consequences of the valence fluctuations in this Kondo semimetal as originally suggested by a Fermi-surface expansion observed in a previous angle-resolved photoemission spectroscopy study [P. Li \textit{et al.}, Phys. Rev. B $\mathbf{100}$, 155110 (2019)].Comment: 7+4 pages, 5+2 figures, 2+1 table

Effects of dispersed fibres in myocardial mechanics, Part I: passive response

It is widely acknowledged that an imbalanced biomechanical environment can have significant effects on myocardial pathology, leading to adverse remodelling of cardiac function if it persists. Accurate stress prediction essentially depends on the strain energy function which should have competent descriptive and predictive capabilities. Previous studies have focused on myofibre dispersion, but not on fibres along other directions. In this study, we will investigate how fibre dispersion affects myocardial biomechanical behaviours by taking into account both the myofibre dispersion and the sheet fibre dispersion, with a focus on the sheet fibre dispersion. Fibre dispersion is incorporated into a widely-used myocardial strain energy function using the discrete fibre bundle approach. We first study how different dispersion affects the descriptive capability of the strain energy function when fitting to ex vivo experimental data, and then the predictive capability in a human left ventricle during diastole. Our results show that the chosen strain energy function can achieve the best goodness-of-fit to the experimental data by including both fibre dispersion. Furthermore, noticeable differences in stress can be found in the LV model. Our results may suggest that it is necessary to include both dispersion for myofibres and the sheet fibres for the improved descriptive capability to the ex vivo experimental data and potentially more accurate stress prediction in cardiac mechanics

Structure-Guided Image Completion with Image-level and Object-level Semantic Discriminators

Structure-guided image completion aims to inpaint a local region of an image according to an input guidance map from users. While such a task enables many practical applications for interactive editing, existing methods often struggle to hallucinate realistic object instances in complex natural scenes. Such a limitation is partially due to the lack of semantic-level constraints inside the hole region as well as the lack of a mechanism to enforce realistic object generation. In this work, we propose a learning paradigm that consists of semantic discriminators and object-level discriminators for improving the generation of complex semantics and objects. Specifically, the semantic discriminators leverage pretrained visual features to improve the realism of the generated visual concepts. Moreover, the object-level discriminators take aligned instances as inputs to enforce the realism of individual objects. Our proposed scheme significantly improves the generation quality and achieves state-of-the-art results on various tasks, including segmentation-guided completion, edge-guided manipulation and panoptically-guided manipulation on Places2 datasets. Furthermore, our trained model is flexible and can support multiple editing use cases, such as object insertion, replacement, removal and standard inpainting. In particular, our trained model combined with a novel automatic image completion pipeline achieves state-of-the-art results on the standard inpainting task.Comment: 18 pages, 16 figure

Symptoms of anxiety and depression predicting fall-related outcomes among older Americans: a longitudinal study

BackgroundAnxiety and depressive symptoms are associated with fear of falling and fear of falling-related activity restrictions. However, it remains unknown whether anxiety or depressive symptoms alone could predict fear of falling and activity restrictions in older adults. We sought to determine if anxiety and depressive symptoms alone could be an independent predictor of fear of falling and activity restrictions in community-dwelling older adults.MethodsThis longitudinal analysis used waves 5 (time 1, [T1]) and 6 (time 2, [T2], 1 year from T1) data (N = 6376) from the National Health and Aging Trends Study. The Generalized Anxiety Disorder Scale 2 and Patient Health Questionnaire 2 were used to assess anxiety and depressive symptoms, respectively. Interview questions included demographics, health-related data, and fall worry levels (no fear of falling, fear of falling but no activity restrictions, and activity restrictions). Using multinomial logistic regression models, we examined whether anxiety and depressive symptoms (T1) predicted fear of falling and activity restrictions (T2).ResultsIn wave 5 (T1, mean age: 78 years, 58.1% female), 10 and 13% of participants reported anxiety and depressive symptoms. About 19% of participants experienced fear of falling but not activity restrictions, and 10% of participants developed activity restrictions in wave 6 (T2), respectively. Participants with anxiety symptoms at T1 had a 1.33 times higher risk of fear of falling (95% CI = 1.02–1.72) and 1.41 times higher risk of activity restrictions (95% CI = 1.04–1.90) at T2. However, having depressive symptoms did not show any significance after adjusting for anxiety symptoms.ConclusionsAnxiety symptoms seemed to be an independent risk factor for future fear of falling and activity restrictions, while depressive symptoms were not. To prevent future fear of falling and activity restrictions, we should pay special attention to older individuals with anxiety symptoms.</p

COVID-19 vaccination coverage among adolescents aged 12–17 years in three provinces of eastern China: A cross-sectional survey, 2021

High vaccination coverage is essential to prevent and control the spread of the COVID-19 epidemic. Currently, the real-world acceptance of COVID-19 vaccines among adolescents aged 12–17 years in China has not been reported. We aimed to assess the acceptance rate of COVID-19 vaccination among adolescents in eastern China and to identify factors associated with the intention to get vaccinated against COVID-19. We conduct a cross-sectional questionnaire survey among adolescents from three provinces in the eastern part of China from 16 August to 28 October 2021. The questionnaires were distributed to 2,100 students, and 2,048 students completed the questionnaires. The results showed that 98.4% (2,016/2,048) of adolescents had received at least one dose of the COVID-19 vaccine and 1.6% (32/2,048) declined the vaccination. The participants from rural districts, or whose parents were vaccinated, were more likely to accept the vaccine. The main reason for declining vaccination was worry about vaccine safety (25%). The main adverse event after the vaccination was pain at the injection site. In conclusion, the vaccine coverage rate reached 98.4% among the adolescents in this study, which met the criteria for herd immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The high vaccination rate is beneficial to the prevention and control of the COVID-19 pandemic

Effects of Linpan nature therapy on health benefits in older women with and without hypertension

BackgroundNature therapy can significantly benefit the physiology and psychology of middle-aged and older people, but previous studies have focused on forest environments. The restoration potential of rural environments in urban fringe areas, which are more accessible to older people on a daily basis, has not been fully studied. This study assessed the effects of nature therapy on the physical and mental health of older women in a rural setting (locally known as Linpan) in the urban fringe area of Chengdu, China.MethodsWe recruited a total of 60 older women (65.3 ± 5.5 years old) living in cities for 3 days of nature therapy in the winter (30 subjects) and spring (30 subjects), including 20 hypertensive patients.ResultsThe results showed that the overall blood pressure, pulse and sleep dysfunction rating scores of the participants were significantly lower than the pretest levels, and the finger blood oxygen saturation, mid-day salivary alpha-amylase and cortisol were increased post-treatment. Increases in these biomarker indicates and increase in stress. There were significant differences in the changes in systolic blood pressure between the hypertension group (HTN) and the normal group (normal) (HTN decreased by 8.8%, normal decreased by 5.4%), salivary alpha-amylase content (HTN decreased by 0.3%, normal increased by 16.9%), and sleep dysfunction rating scores (HTN decreased by 59.6%, normal decreased by 54%). The decreases in systolic blood pressure and pulse in the winter group were higher than those in the spring group by 1.8 and 4.4%, respectively, while the increases in salivary alpha-amylase content and salivary cortisol content were lower than those in the spring group by 11.7 and 11.2%, respectively, and the decrease in sleep dysfunction rating scores was lower than that in the spring group by 7.1%.ConclusionOur study concluded that nature therapy based on various health activities in the Linpan has significant health effects on older women. It can regulate blood pressure and pulse in older women, relieve cardiovascular disease, improve sleep quality. Meanwhile, older women with high blood pressure experienced a more significant effect than the healthy group

Effects of forest spatial types, element compositions and forest stands on restorative potential and aesthetic preference

IntroductionAs global urbanization intensifies, the physical and mental stressors of modern life have led to the growing prevalence of suboptimal health conditions. Spending time in a forest benefits human health and well-being. In this context, based on the forest spatial types (forest interior and forest edge spaces), landscape elements (architecture, water and roads) and forest stands (coniferous, broadleaf and bamboo forests), this study investigated the effects of different forest spatial landscape characteristics on the restorative potential for college students, aesthetic preference and eye movement behavior (total fixation duration and fixation count).MethodsIn this study, a total of 60 subjects were exposed to 42 photographs depicting typical forest landscapes acquired through field studies. The Short-version Revised Restoration and Preference Scale and eye-tracking technology, were employed to study the recovery efficiency and visual attraction of forest spatial of different forest spatial types, element compositions and forest stands.Results(1) The restorative potential and aesthetic preference score of forest edge spaces were significantly higher than those of forest interior spaces. (2) The restorative potential of bamboo forests was significantly higher than those of coniferous and broadleaf forests. (3) In terms of forest interior space, the restorative potential of “forest + 1 element” composition and “forest + 2 elements” composition was significantly higher than that of pure forest, and the restorative potential of interior space of bamboo forest was significantly higher than those of coniferous and broadleaf forests. (4) In terms of forest edge space, the restorative potential of “forest + 2 elements” composition was significantly higher than that of pure forest, and the restorative potential of pure forests was significantly higher than that of the “forest + 1 element” composition. (5) The restorative potential of forest spatial landscape characteristics positively correlated with aesthetic preference and negatively correlated with total fixation duration and fixation count. These results can provide a reference for future forest landscape research, construction and management

Iodine Excess as an Environmental Risk Factor for Autoimmune Thyroid Disease

The global effort to prevent iodine deficiency disorders through iodine supplementation, such as universal salt iodization, has achieved impressive progress during the last few decades. However, iodine excess, due to extensive environmental iodine exposure in addition to poor monitoring, is currently a more frequent occurrence than iodine deficiency. Iodine excess is a precipitating environmental factor in the development of autoimmune thyroid disease. Excessive amounts of iodide have been linked to the development of autoimmune thyroiditis in humans and animals, while intrathyroidal depletion of iodine prevents disease in animal strains susceptible to severe thyroiditis. Although the mechanisms by which iodide induces thyroiditis are still unclear, several mechanisms have been proposed: (1) excess iodine induces the production of cytokines and chemokines that can recruit immunocompetent cells to the thyroid; (2) processing excess iodine in thyroid epithelial cells may result in elevated levels of oxidative stress, leading to harmful lipid oxidation and thyroid tissue injuries; and (3) iodine incorporation in the protein chain of thyroglobulin may augment the antigenicity of this molecule. This review will summarize the current knowledge regarding excess iodide as an environmental toxicant and relate it to the development of autoimmune thyroid disease