Association between increased C-reactive protein and cardiovascular disease among patients with rectal cancer

PurposeThis study aimed to investigate the association between increased C-reactive protein (CRP) and cardiovascular disease (CVD) in individuals with rectal cancer, as well as to understand the effect of chemotherapy for cancer on increasing CRP and its underlying mechanisms.Patients and methodsFrom January 1, 2010 to December 31, 2020, individuals with rectal cancer were evaluated at the First Affiliated Hospital of Gannan Medical University. Then, in patients with rectal cancer, the relationship between increased CRP and CVD attributes was summarized, and the impact of chemotherapy on CRP levels was qualitatively assessed. For further investigation into potential regulatory mechanisms of CRP, differentially expressed genes (DEGs), GO and KEGG enrichment analyses were conducted.ResultsA total of 827 individuals were included in the study, including 175 with CVD (21.16%) and 652 without CVD. A significant association between increased CRP and CVD events was observed in rectal cancer patients (p < 0.01), and it significantly improved the classification performance of the CVD predictive model in the AUC (0.724 vs 0.707) and NRI (0.069, 95% CI 0.05-0.14). Furthermore, a comparison of CRP levels before and after chemotherapy revealed a significant increase among rectal cancers post-treatment (p < 0.001). Analysis of differentially expressed genes and co-expression indicated that 96 DEGs were involved in the pathophysiology of increased CRP after chemotherapy, and three hub genes were implicated in atherosclerotic susceptibility.ConclusionIn conclusion, our findings indicated that increased CRP levels following chemotherapy profoundly impacted CVD events in individuals with rectal cancer, and may be beneficial in promoting CVD prediction in clinical practice

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10−11 for rs4733781; P = 1.0 × 10−10 for rs10956514). Dendritic cells (DCs) showed high ASAP1 expression that was reduced after Mycobacterium tuberculosis infection, and rs10956514 was associated with the level of reduction of ASAP1 expression. The ASAP1 protein is involved in actin and membrane remodeling and has been associated with podosomes. The ASAP1-depleted DCs showed impaired matrix degradation and migration. Therefore, genetically determined excessive reduction of ASAP1 expression in M. tuberculosis–infected DCs may lead to their impaired migration, suggesting a potential mechanism of predisposition to TB

A heterozygous moth genome provides insights into herbivory and detoxification

How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants1, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood2. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.Minsheng You … Simon W Baxter … et al

Decisions of Knowledge Payment Product Supply Chain Considering Government Subsidies and Anti-Piracy Efforts: Based on China’s Knowledge Payment Market

Knowledge payment is an emerging business mode that has developed in the era of social media. With the impact of Internet technology, the knowledge payment market is rapidly expanding, especially in China. However, piracy leads to more intense competition and affects the profits of knowledge providers and knowledge payment platforms. Government policies combined with the anti-piracy measures of these platforms have become effective methods to combat piracy. This paper investigates the impact of government subsidies and anti-piracy efforts on a knowledge provider’s and platform’s optimal decisions. We develop a two-stage knowledge payment product supply chain with a knowledge provider and a knowledge payment platform. The platform in the leader position of the supply chain has anti-piracy efforts and the government subsidizes the platform. Stackelberg game models are constructed and compared to examine the equilibrium solution in relation to three modes (no government subsidies and no anti-piracy efforts; only anti-piracy efforts; and both government subsidies and anti-piracy efforts). Our analysis shows that (1) both government subsidies and anti-piracy efforts increase the quality level and unit quality signing bonus of the knowledge payment product. Meanwhile, the product’s retail price increases with anti-piracy efforts but decreases within a certain subsidy range. (2) The knowledge provider’s profit always increases with the anti-piracy effort level, while the platform’s profit is an inverted U-shaped relationship with the anti-piracy effort level. (3) Government subsidy behavior can always increase a knowledge provider’s profit but may not necessarily increase the platform’s profit. Moreover, there exists a certain threshold: when subsidies are lower (higher) than this threshold, it is more beneficial to the knowledge provider (platform). In addition, we also find that the method of high subsidies combined with a low anti-piracy effort level benefits both parties and that the subsidized party will be more sensitive. The results will provide knowledge providers and platforms with new market management insights from the perspective of government subsidies and anti-piracy efforts and guide them to make optimal decisions

Adaptive Neural Control of Hypersonic Vehicles with Actuator Constraints

An adaptive neural control method is proposed in this paper for the flexible air-breathing hypersonic vehicle (AHV) with constraints on actuators. This scheme firstly converts the original control problem with input constraints into a new control problem without input constraints based on the control input saturation function. Secondly, on the basis of the implicit function theorem, the radial basis function neural network (RBFNN) is introduced to approximate the uncertain items of the model. And the minimal-learning-parameter (MLP) technique is adopted to design the adaptive law for the norm of network weight vector, which significantly reduces calculations. Meanwhile, the finite-time convergence differentiator (FD) is introduced, through which the model state variables and their derivatives are accurately estimated to ensure the control effect. Finally, it is theoretically proved that the closed-loop control system is stable. And the effectiveness of the designed controller is verified by simulation

Trajectory Optimization for High-Speed and Long-Range Interceptor Based on Improved Adaptive hp Pseudospectral Method

The trajectory optimization design of interceptor is very important in the defense combat against a class of high-speed and strong-maneuvering aircraft. At present, an important idea is to use hp pseudospectral method to offline optimizes the trajectory of interceptor, but the solving efficiency of this method needs to be further improved. Aiming at this issue, an improved adaptive hp pseudospectral method is proposed in this paper. In order to shorten the solving time of the algorithm, the proposed method has two main improvements on the basis of the traditional hp pseudospectral method: on one hand, by judging the positions of the control sudden change points, prerefine the mesh around them according to certain rules. On the other hand, the curvature of the system state curve is used as the criterion to segment the original mesh nonuniformly so that more mesh points can be allocated where the curvature is large. These two points together ensure that the collocation point resources can be used more efficiently in the mesh refinement process. The simulation results show that the proposed method can solve the optimized trajectory of interceptor effectively, and it also proves that this method has higher solving efficiency than the traditional adaptive hp method

Prescribed Performance Control for Two-axis Optronic Stabilized Platform

Aiming at improving the tracking and stabilizing performance of two-axis optronic stabilized platform with Stribeck friction and uncertain velocity disturbance, a prescribed performance control strategy with unknown initial errors is designed. By designing a new performance function, the limit of traditional prescribed control that the initial error has to be known accurately is broken through. The strategy possesses strong robustness against unknown disturbance, and the state error is restrained to a predefined arbitrary small residual. It is guaranteed that the closed-loop system is uniformly ultimately bounded. The simulation results demonstrate the effectiveness of proposed strategy

Noncertainty Equivalent Adaptive Backstepping Control for Advanced Fighter Subject to Unsteady Effects and Input Constraints

This paper presents a noncertainty equivalent adaptive backstepping control scheme for advanced fighter attitude tracking, in which unsteady effects, parameter uncertainties, and input constraints are all considered which increase the design difficulty to a large extent. Based on unsteady attitude dynamics and the noncertainty equivalent principle, a new observer is first developed to reconstruct the immeasurable and time-varying unsteady states. Afterwards, the unsteady aerodynamics is compensated in the backstepping controller where the command filter is introduced to impose physical constraints on actuators. In order to further enhance the robustness, the noncertainty equivalent adaptive approach is again used to estimate the uncertain constant parameters. Moreover, stability of the closed-loop system that includes the state observer, parameter estimator, and backstepping controller is proven by the Lyapunov theorem in a unified architecture. Finally, simulation results show that performance of the deterministic control system can be captured when attractive manifolds are achieved. The effectiveness and robustness of the proposed control scheme are verified by the Herbst maneuver

Prescribed Performance Control for Two-axis Optronic Stabilized Platform

Aiming at improving the tracking and stabilizing performance of two-axis optronic stabilized platform with Stribeck friction and uncertain velocity disturbance, a prescribed performance control strategy with unknown initial errors is designed. By designing a new performance function, the limit of traditional prescribed control that the initial error has to be known accurately is broken through. The strategy possesses strong robustness against unknown disturbance, and the state error is restrained to a predefined arbitrary small residual. It is guaranteed that the closed-loop system is uniformly ultimately bounded. The simulation results demonstrate the effectiveness of proposed strategy