Refuge-Deptford mortuary complex

179 p. : ill., maps ; 26 cm.AMNH Library's copies lack t.p.Includes bibliographical references (p. 173-179).Mortuary archaeology on the Georgia coast / David Hurst Thomas and Clark Spencer Larsen -- Archaeological techniques and procedures / David Hurst Thomas and Clark Spencer Larsen -- The Cunningham Mound group / David Hurst Thomas, Clark Spencer Larsen, and Ann Marie Lunsford -- Seaside Mound group / David Hurst Thomas, Clark Spencer Larsen, and Ann Marie Lunsford -- Ceramics / Chester B. DePratter -- Comparisons / David Hurst Thomas -- Implications and some speculations / David Hurst Thomas -- Appendix. Seasonal growth variations in the shells of recent and prehistoric specimens of Mercenaria mercenaria from St. Catherines Island, Georgia / George R. Clark II."Data and implications from nine burial mounds excavated by crews of the American Museum of Natural History on St. Catherines Island, Georgia, are given in this monograph. As a group, these nine sites define a surprisingly homogeneous pattern and these data comprise virtually all that is known regarding the mortuary customs practiced along the Georgia and Florida coast between ca. 1500 B.C. to A.D. 600. The sites are rather unspectacular sand mounds, which exhibit a remarkably consistent stratigraphic patterning. The skeletal materials recovered are poorly preserved, except in the rare case when shell was added to the interment. The radiocarbon evidence, consisting of 29 determinations from the nine mounds, strongly suggests a marked periodicity in the use of these sites. In all cases, the areas seem to have been visited for centuries - in some cases millenia - prior to the actual construction of the mortuary mound. Several graves were placed into this pre-mound surface, and mound-building activities occurred at all sites sometime during the first 600 years A.D. A number of intrusive burials were added shortly thereafter, and then ceremonial activities virtually ceased at all sites. Most cultural materials found inside the mounds were accidental inclusions which resulted from pre-mound sacred (and probably secular) activities. Very few deliberate grave offerings were found. The biocultural evidence suggests that the Refuge-Deptford population enjoyed good health, although they suffered from an extreme rate of dental attrition. Although the data are limited, these sites seem to reflect an egalitarian sociopolitical organization operative during Refuge-Deptford times. The relatively high proportion of bundle burials seems to suggest that the annual round of these peoples exploited both island and mainland resources. We offer a number of cautious speculations regarding the nature of ritual and symbolism during the Refuge and Deptford phases. These suggestions are a variety of hypotheses that require testing with data from both mortuary and habitation sites of this period"--P. 5

Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity

The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with a disrupted Dio2 gene (D2KO) have an impaired response to cold. BAT is also activated by overfeeding.After 6-weeks of HFD feeding D2KO mice gained 5.6% more body weight and had 28% more adipose tissue. Oxygen consumption (V0(2)) was not different between genotypes, but D2KO mice had an increased respiratory exchange ratio (RER), suggesting preferential use of carbohydrates. Consistent with this, serum free fatty acids and β-hydroxybutyrate were lower in D2KO mice on a HFD, while hepatic triglycerides were increased and glycogen content decreased. Neither genotype showed glucose intolerance, but D2KO mice had significantly higher insulin levels during GTT independent of diet. Accordingly, during ITT testing D2KO mice had a significantly reduced glucose uptake, consistent with insulin resistance. Gene expression levels in liver, muscle, and brown and white adipose tissue showed no differences that could account for the increased weight gain in D2KO mice. However, D2KO mice have higher PEPCK mRNA in liver suggesting increased gluconeogenesis, which could also contribute to their apparent insulin resistance.We conclude that the loss of the Dio2 gene has significant metabolic consequences. D2KO mice gain more weight on a HFD, suggesting a role for D2 in protection from diet-induced obesity. Further, D2KO mice appear to have a greater reliance on carbohydrates as a fuel source, and limited ability to mobilize and to burn fat. This results in increased fat storage in adipose tissue, hepatic steatosis, and depletion of liver glycogen in spite of increased gluconeogenesis. D2KO mice are also less responsive to insulin, independent of diet-induced obesity

Complications Occurring Through 5 Years Following Primary Intraocular Lens Implantation for Pediatric Cataract

Importance Lensectomy with primary intraocular lens (IOL) implantation is often used in the management of nontraumatic pediatric cataract, but long-term data evaluating the association of age and IOL location with the incidence of complications are limited. Objective To describe the incidence of complications and additional eye surgeries through 5 years following pediatric lensectomy with primary IOL implantation and association with age at surgery and IOL location. Design, Setting, and Participants This prospective cohort study used Pediatric Eye Disease Investigator Group cataract registry data from 61 institution- and community-based practices over 3 years (June 2012 to July 2015). Participants were children younger than 13 years without baseline glaucoma who had primary IOL implantation (345 bilateral and 264 unilateral) for nontraumatic cataract. Data analysis was performed between September 2021 and January 2023. Exposures Lensectomy with primary IOL implantation. Main Outcome and Measures Five-year cumulative incidence of complications by age at surgery (<2 years, 2 to <4 years, 4 to <7 years, and 7 to <13 years) and by IOL location (sulcus vs capsular bag) were estimated using Cox proportional hazards models. Results The cohort included 609 eyes from 491 children (mean [SD] age, 5.6 [3.3] years; 261 [53%] male and 230 [47%] female). Following cataract extraction with primary IOL implantation, a frequent complication was surgery for visual axis opacification (VAO) (cumulative incidence, 32%; 95% CI, 27%-36%). Cumulative incidence was lower with anterior vitrectomy at the time of IOL placement (12%; 95% CI, 8%-16%) vs without (58%; 95% CI, 50%-65%), and the risk of undergoing surgery for VAO was associated with not performing anterior vitrectomy (hazard ratio [HR], 6.19; 95% CI, 3.70-10.34; P < .001). After adjusting for anterior vitrectomy at lens surgery, there were no differences in incidence of surgery for VAO by age at surgery (<2 years, HR, 1.35 [95% CI, 0.63-2.87], 2 to <4 years, HR, 0.86 [95% CI, 0.44-1.68], 4 to <7 years, HR, 1.06 [95% CI, 0.72-1.56]; P = .74) or by capsular bag vs sulcus IOL fixation (HR, 1.22; 95% CI, 0.36-4.17; P = .75). Cumulative incidence of glaucoma plus glaucoma suspect by 5 years was 7% (95% CI, 4%-9%), which did not differ by age after controlling for IOL location and laterality. Conclusions and Relevance In this cohort study, a frequent complication following pediatric lensectomy with primary IOL was surgery for VAO, which was associated with primary anterior vitrectomy not being performed but was not associated with age at surgery or IOL location. The risk of glaucoma development across all ages at surgery suggests a need for long-term monitoring