27 research outputs found
Evaluation of Gastrointestinal Solubilization of Petroleum Hydrocarbon Residues in Soil Using an In Vitro Physiologically Based Model
Comparison of the Wetting Properties of Three Commonly Used Simulated Intestinal Fluids Used as Dissolution Media in the Characterization of Drugs
THE ROLE OF ELECTROSTATIC AND STRUCTURAL PROPERTIES OF THE CELL SURFACE IN THE ENERGETICS OF CELL-CELL AND CELL-SURFACE INTERACTION
Nanoscale Cellulose Films with Different Crystallinities and Mesostructures—Their Surface Properties and Interaction with Water
Importance of Surface Tension Characterization for Food, Pharmaceutical and Packaging Products: A Review
The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug
Simulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of drug formulations. To reduce the size and number of human studies required to identify a drug product with appropriate performance in both the fed and fasted states, it is advantageous to be able to pre-screen formulations in vitro. The choice of appropriate media for such in vitro tests is crucial to their ability to correctly forecast the food effect in pharmacokinetic studies. The present paper gives an overview of the development and composition of biorelevant dissolution media that can be used for the in vitro simulation of different dosing conditions (fasted and fed states). In addition, the application of these media to predicting food effects is described in several case examples