Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: The ZIKAlliance consortium

Background: The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were selected over a wide geographic range within Latin America and the Caribbean, taking into account the dynamic course of the ZIKV epidemic. Methods: Recruitment to the PW cohort will take place in antenatal care clinics. PW will be enrolled regardless of symptoms and followed over the course of pregnancy, approximately every 4 weeks. PW will be revisited at delivery (or after miscarriage/abortion) to assess birth outcomes, including microcephaly and other congenital abnormalities according to the evolving definition of congenital Zika syndrome (CZS). After birth, children will be followed for 2 years in the CH cohort. Follow-up visits are scheduled at ages 1-3, 4-6, 12, and 24 months to assess neurocognitive and developmental milestones. In addition, a NH cohort for the characterization of symptomatic rash/fever illness was designed, including follow-up to capture persisting health problems. Blood, urine, and other biological materials will be collected, and tested for ZIKV and other relevant arboviral diseases (dengue, chikungunya, yellow fever) using RT-PCR or serological methods. A virtual, decentralized biobank will be created. Reciprocal clinical monitoring has been established between partner sites. Substudies of ZIKV seroprevalence, transmissio

Restoring Leviathan? The Kenyan Supreme Court, constitutional transformation, and the presidential election of 2013

This paper analyzes the Kenya Supreme Court's ruling in Odinga v IEBC, a petition challenging the declared outcome of the 2013 presidential election. The case was immediately significant given the hope that recourse to the courts would help to avoid widespread civil unrest which had followed the disputed presidential election of 2007. It was also a crucial test for the new dispensation established under the 2010 Constitution widely held to have broken with the authoritarian and unaccountable regimes which dominated Kenya both under colonialism and after independence. The paper critically reviews the reasoning of the Supreme Court on six key issues raised in the petition attending to the broader normative and political implications of the judgment. We argue that both in its substantive conclusions and in the style of reasoning adopted, Odinga v IEBC is inconsistent with the transformative ambitions underpinning the new constitution. Through its emphasis on evidential and procedural rules, rather than principled analysis, the judgment tends to reinforce the powers of the executive and the model of a unitary state beyond the reach of the law