2 research outputs found
Inhaled dry salt micro particles in the treatment of bronchopulmonary dysplasia: a five case series report
Background. Despite current medical advances,
to this day there is no single medical
intervention to effectively prevent or
treat bronchopulmonary dysplasia (BPD)
in both preterm and term infants. Along
with protective ventilation strategies, various
drugs are being used or are being researched
at this very moment, with the sole
purpose of improving the general outcome
for these patients. Inhaled dry salt micro
particles therapy is now one of them.
Materials and methods. This report presents
five patients, diagnosed with severe
BPD. All of them received, complementary
to classical BPD management and
respiratory support, continuous inhaled
dry salt micro particles, via SaltMed cartridges,
for a period of 12 to 30 days. After
only 24 hours of administration, we were
able to observe a significant improvement
in respiratory function and dynamics. It
was possible to use a lower fraction of inspired
oxygen (FiO2), mean airway pressure
(MAP) and peak inspiratory pressure
(PIP) in all mechanically ventilated patients.
Higher tidal volumes were recorded
and we observed improvement in oxygenation
indexes.
Conclusion. Continuously inhaled dry salt
micro particles, administered complementary
to classic BPD management, could
improve respiratory and overall morbidity
and mortality in infants with any form
of BPD. Further study of these possible
effects is needed, as there is no data published
on this matter so far
Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Berdon’s syndrome - First Report in Romania
Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS) is a rare motility disorder with high mortality rate described by Berdon in 1976. We present the first case of Berdon’s syndrome (heterozygous pathogenic variant in the ACTG2 gene) reported in Romania, a female newborn admitted in NICU “Marie S. Curie” Emergency Children’s Hospital Bucharest for intestinal obstruction after birth. Total parenteral nutrition, ileostomy, gastrostomy, clean intermittent bladder catheterisation, evaluation for multivisceral transplantation were performed. She was discharged from our NICU ward at the age of 4 years and 2 months with home total parenteral nutrition administered by her mother in sterile condition, clean intermittent catheterisation for bladder evacuation performed by her mother, monitored monthly for about three years, with normal cardio-respiratory function, no signs of thrombosis, she maintained relatively low platelet count without positive blood culture, good liver and renal function test. Normal neurological and psychomotor development according to age. Her course was complicated by multiorgan failure with death ensuing at the age of 7 years and 10 months