Multimodal particle size distribution or fractal surface of acrylic acid copolymer nanoparticles: A small-angle X-ray scattering study using direct Fourier and indirect maximum entropy methods

Acrylic acid copolymers are potential carriers for drug delivery. The surface, surface rugosity and the absolute dimension of the particles are parameters that determine the binding of drugs or detergents, diffusion phenomena at the surface and the distribution of the carrier within the human body. The particle-size distribution and surface rugosity of the particles have been investigated by small-angle X-ray scattering and dynamic light scattering. Direct Fourier transform as well as a new strategy for the indirect maximum-entropy method MAXENT are used for data evaluation. Scattering equivalence of a pure multimodal distribution of hard spheres (five populations) and a mixed multimodal-surface-fractal model (four populations) was found. Model calculations and dynamic light-scattering experiments gave evidence of the multimodal particle-size distribution combined with the fractal surface of the carrier The main moiety consists of particles 90 nm in diameter which are surface fractals in the 10 nm region

cGMP kinase I regulates glucagon release

© 2009 Leiss et al; licensee BioMed Central Ltd. Blood glucose levels are tightly controlled by the two peptide hormones glucagon and insulin. At hyperglycaemia, B-cells in the islets of Langerhans secrete insulin, whereas islet A-cells release glucagon at hypoglycaemia to stimulate e.g. glucose production in the liver. Previously, an important role for nitric oxide (NO) in the development of type-1 diabetes mellitus (insulin dependent diabetes mellitus) was reported [1]. The mechanisms are unknown whereby NO modulates islet (mal-)function. We hypothesized that NO signals via the cGMP/cGMP kinase I (cGKI) pathway to modulate the endocrine control of blood glucose levels. Glucose homeostasis was studied in the conventional cGKI knockouts (KOs) and in cGKI rescue mice (RM) [2] in comparison to age- and littermat

Infrared Vertical External Cavity Surface Emitting Laser Threshold Magnetometer

Nitrogen-vacancy (NV) centers have considerable promise as high sensitivity magnetometers, however are commonly limited by inefficient collection and low contrasts. Laser threshold magnetometry (LTM) enables efficient collection and high contrasts, providing a path towards higher sensitivity magnetometry. We demonstrate an infrared LTM using an ensemble of NV centers in a single crystal diamond plate integrated into a vertical external cavity surface emitting laser. The laser was tuned to the spin dependent absorption line of the NV centers, allowing for optical readout by monitoring the laser output power. We demonstrate a magnetic sensitivity of 7.5~nT/$\sqrt{\textit{Hz}}$ in the frequency range between 10 and 50 Hz. Furthermore, the contrast and the projected PSNL sensitivity are shown to improve significantly by operating close to the lasing threshold, achieving 18.4\% and 26.6~pT/$\sqrt{\textit{Hz}}$ near threshold. What's more, an unexpected saturable absorption phenomenon was observed near threshold, which enhanced the contrast and projected PSNL sensitivity

Using fNIRS to study working memory of infants in rural Africa

A pilot study was conducted to assess the feasibility of using fNIRS as an alternative to behavioral assessments of cognitive development with infants in rural Africa. We report preliminary results of a study looking at working memory in 12–16-month-olds and discuss the benefits and shortcomings for the potential future use of fNIRS to investigate the effects of nutritional insults and interventions in global health studies

Six and seven loop Konishi from Luscher corrections

In the present paper we derive six and seven loop formulas for the anomalous dimension of the Konishi operator in N=4 SYM from string theory using the technique of Luscher corrections. We derive analytically the integrand using the worldsheet S-matrix and evaluate the resulting integral and infinite sum using a combination of high precision numerical integration and asymptotic expansion. We use this high precision numerical result to fit the integer coefficients of zeta values in the final analytical answer. The presented six and seven loop results can be used as a cross-check with FiNLIE on the string theory side, or with direct gauge theory computations. The seven loop level is the theoretical limit of this Luscher approach as at eight loops double-wrapping corrections will appear.Comment: 18 pages, typos correcte

Konishi operator at intermediate coupling

TBA equations for two-particle states from the sl(2) sector proposed by Arutyunov, Suzuki and the author are solved numerically for the Konishi operator descendent up to 't Hooft's coupling lambda ~ 2046. The data obtained is used to analyze the properties of Y-functions and address the issue of the existence of the critical values of the coupling. In addition we find a new integral representation for the BES dressing phase which substantially reduces the computational time.Comment: lots of figures, v2: improved numerics, c1=2, c2=0, c4 does not vanis

Comments on the Mirror TBA

We discuss various aspects of excited state TBA equations describing the energy spectrum of the AdS_5 \times S^5 strings and, via the AdS/CFT correspondence, the spectrum of scaling dimensions of N = 4 SYM local operators. We observe that auxiliary roots which are used to partially enumerate solutions of the Bethe-Yang equations do not play any role in engineering excited state TBA equations via the contour deformation trick. We further argue that the TBA equations are in fact written not for a particular string state but for the whole superconformal multiplet, and, therefore, the psu(2,2|4) invariance is built in into the TBA construction.Comment: 28 pages, 1 figure, v2: misprints are correcte