Two new species of Marmosopus (Acari: Astigmata) from rodents of the genus Scotinomys (Cricetidae) in Central America

http://deepblue.lib.umich.edu/bitstream/2027.42/57139/1/OP703.pd

Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain

PMD (Pelizaeus–Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Transgenic mice with increased Plp1 [proteolipid protein 1 gene (non-human)] copy number model most aspects of PMD patients with duplications. Hypomyelination and demyelination are believed to cause the neurological abnormalities in mammals with PLP1 duplications. We show, for the first time, intense microglial reactivity throughout the grey and white matter of a transgenic mouse line with increased copy number of the native Plp1 gene. Activated microglia in the white and grey matter of transgenic mice are found as early as postnatal day 7, before myelin commences in normal cerebra. This finding indicates that degeneration of myelin does not cause the microglial response. Microglial numbers are doubled due to in situ proliferation. Compared with the jp (jimpy) mouse, which has much more oligodendrocyte death and hardly any myelin, microglia in the overexpressors show a more dramatic microglial reactivity than jp, especially in the grey matter. Predictably, many classical markers of an inflammatory response, including TNF-α (tumour necrosis factor-α) and IL-6, are significantly up-regulated manyfold. Because inflammation is believed to contribute to axonal degeneration in multiple sclerosis and other neurodegenerative diseases, inflammation in mammals with increased Plp1 gene dosage may also contribute to axonal degeneration described in patients and rodents with PLP1 increased gene dosage

Psorergates desmanae sp. nov., eine neue Kr\ue4tzmilbe von Galemys pyrenaicus (Psorergatidae : Trombidiformes)

Volume: 40Start Page: 125End Page: 13

Amorphacarus parvisetosus spec. nov. (Myobiidae, Trombidiformes), from Neomys fodiens Pennant (Soricidae)

Volume: 114Start Page: 163End Page: 17

Myoproctalges surinamensis, a new genus and species of mite parasitic on the acuchi Myoprocta acouchy from Surinam (Psoroptidae, Psoralginae: Sarcoptiformes)

v.65:no.3 (1974

PARASITES OF WESTERN AUSTRALIA II NASAL MITES FROM BIRDS (ACARINA RHINONYSSIDAE, DERMANYSSIDAE, EREYNETIDAE AND CYTODITIDAE)

Volume: 7Start Page: 9End Page: 2

PARASITES OF WESTERN AUSTRALIA X ATOPOMELIDAE FROM MARSUPIALS (ACARI LISTROPHOROIDEA)

Volume: 8Start Page: 533End Page: 56

PARASITES OF WESTERN AUSTRALIA X ATOPOMELIDAE PARASITIC ON RODENTS (ACARI LISTROPHOROIDEA)

Volume: 8Start Page: 563End Page: 58

PARASITES OF WESTERN AUSTRALIA X LABIDOCARPINAE FROM BATS (ACARI LISTROPHOROIDEA, CHIRODISCIDAE)

Volume: 8Start Page: 517End Page: 53

Life cycle of Apodemopus apodemi (Fain, 1965) (Glycyphagidae: Sarcoptiformes Acari)

Volume: 115Start Page: 325End Page: 33