AN INTEGRATED APPROACH FOR DESIGN AND MANUFACTURE OF PLASTIC PRODUCTS

The aim of this paper is to present an integrated design procedure for plastic part development and manufacture. Reverse engineering (RE), re-engineering (ReE) and mold design have been incorporated to infuse agile characteristics in the proposed design and development process. The integration of RE and ReE presented in this paper accelerate the design process and provide information necessary for complete injection molding process of plastic parts. The purpose is to create a new object geometrically similar to the existing object. The new object must have better mechanical properties and more favorable geometry from the standpoint of mold ability. This paper also, describes a methodology for quality geometry check of the manufactured part that is need for verified the used integrated CAD/CAE technologies

Two-Stage Precoding Based on Overlapping User Grouping Approach in IoT-Oriented 5G MU-MIMO Systems

Downlink transmission techniques for multiuser (MU) multiple-input multiple-output (MIMO) systems have been comprehensively studied during the last two decades. The well-known low complexity linear precoding schemes are currently deployed in long-term evolution (LTE) networks. However, these schemes exhibit serious shortcomings in scenarios when users’ channels are strongly correlated. The nonlinear precoding schemes show better performance, but their complexity is prohibitively high for a real-time implementation. Two-stage precoding schemes, proposed in the standardization process for 5G new radio (5G NR), combine these two approaches and present a reasonable trade-off between computational complexity and performance degradation. Before applying the precoding procedure, users should be properly allocated into beamforming subgroups. Yet, the optimal solution for user selection problem requires an exhaustive search which is infeasible in practical scenarios. Suboptimal user grouping approaches have been mostly focused on capacity maximization through greedy user selection. Recently, overlapping user grouping concept was introduced. It ensures that each user is scheduled in at least one beamforming subgroup. To the best of our knowledge, the existing two-stage precoding schemes proposed in literature have not considered overlapping user grouping strategy that solves user selection, ordering, and coverage problem simultaneously. In this paper, we present a two-stage precoding technique for MU-MIMO based on the overlapping user grouping approach and assess its computational complexity and performance in IoT-oriented 5G environment. The proposed solution deploys two-stage precoding in which linear zero forcing (ZF) precoding suppresses interference between the beamforming subgroups and nonlinear Tomlinson-Harashima precoding (THP) mitigates interuser interference within subgroups. The overlapping user grouping approach enables additional capacity improvement, while ZF-THP precoding attains balance between the capacity gains and suffered computational complexity. The proposed algorithm achieves up to 45% higher MU-MIMO system capacity with lower complexity order in comparison with two-stage precoding schemes based on legacy user grouping strategies

Correlation of gut microbiota composition with resistance to experimental autoimmune encephalomyelitis in rats

Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). It is widely accepted that autoimmune response against the antigens of the CNS is the essential pathogenic force in the disease. It has recently become increasingly appreciated that activated encephalitogenic cells tend to migrate towards gut associated lymphoid tissues (GALT) and that interrupted balance between regulatory and inflammatory immunity within the GALT might have decisive role in the initiation and propagation of the CNS autoimmunity. Gut microbiota composition and function has the major impact on the balance in the GALT. Thus, our aim was to perform analyses of gut microbiota in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Albino Oxford (AO) rats that are highly resistant to EAE induction and Dark Agouti (DA) rats that develop EAE after mild immunization were compared for gut microbiota composition in different phases after EAE induction. Microbial analyses of the genus Lactobacillus and related lactic acid bacteria showed higher diversity of Lactobacillus spp. in EAE-resistant AO rats, while some members of Firmicutes and Proteobacteria (Undibacterium oligocarboniphilum) were detected only in faeces of DA rats at the peak of the disease (between 13 and 16 days after induction). Interestingly, Turicibacter sp. that was found exclusively in non-immunized AO, but not in DA rats in our previous study was detected in DA rats that remained healthy 16 days after induction. Similar observation was obtained for the members of Lachnospiraceae. As dominant presence of the members of Lachnospiraceae family in gut microbial community has been linked with mild symptoms of various diseases, it is tempting to assume that Turicibacter sp. and Lachnospiraceae contribute to the prevention of EAE development and the alleviation of the disease symptoms. Further, production of a typical regulatory cytokine interleukin-10 was compared in GALT cells of AO and DA rats, and higher production was observed in DA rats. Our data contribute to the idea that gut microbiota and GALT considerably influence multiple sclerosis pathogenesis

Endovascular treatment of different types of iliac occlusions-Results from an observational study.

OBJECTIVE:The aim of this study was to evaluate the results of endovascular therapy on the treatment of different types of iliac occlusions. MATERIALS AND METHODS:A bi-center prospective, non-randomized study was conducted on 100 patients (mean age 59.14 ± 8.53; 64 men) who underwent endovascular treatment of iliac occlusive disease between January 2013 and November 2017. We evaluated baseline data, procedure, and follow-up results for the entire group, and according to Trans-Atlantic Inter-Society Consensus (TASC II) classification. The majority of patients (60%) were treated for severe claudication; 56 (56%) patients had TASC B occlusions, 28 patients TASC C, and 16 patients TASC D. RESULTS:The mean length of the occluded segments was 61.41 ± 35.15 mm. Procedural complications developed in 6 patients (6%). Mean ankle-brachial pressure index increased from 0.40 ± 0.12 preoperatively to 0.82 ± 0.16 postoperatively. The mean follow-up was 33.18 ± 15.03 months. After 1 and 5 years, the primary patency rates were 98% and 75.1%, and the secondary patency rate was 97% respectively. Regarding occlusion complexity there were no statistical significant differences in primary patency rates (TASC B vs. C vs. D: p = 0.19). There were no statistically significant differences in primary patency rates between patients in different clinical stages, as well as between the type of stents, and location of the occlusion. CONCLUSION:In our study, endovascular treatment for iliac artery occlusions proved to be a safe and efficient approach with excellent primary and secondary patency rates regardless of the complexity of occlusions defined by TASC II classification. This study is aligned with the notion that in well selected patients, endovascular therapy can be the treatment of choice even in complex iliac lesions if performed by experienced endovascular interventionists in high volume centers

Improving Global Supply Chain Management (Semester Unknown) IPRO 306: ImprovingGlobalSupplyChainManagementIPRO306FinalReportSp10_redacted

The IPRO 306 team will be working with a sanitation and janitorial equipment manufacturer, Sloan Valve. The core competency of this company lies in manufacturing flush valves. Sloan Valve is currently one of the leading producers of flush valves in the Northern American Continent. The team will be assisting Sloan Valve in realizing two major projects.Sponsorship: SLOANDeliverable

Improving Global Supply Chain Management (Semester Unknown) IPRO 306

The IPRO 306 team will be working with a sanitation and janitorial equipment manufacturer, Sloan Valve. The core competency of this company lies in manufacturing flush valves. Sloan Valve is currently one of the leading producers of flush valves in the Northern American Continent. The team will be assisting Sloan Valve in realizing two major projects.Sponsorship: SLOANDeliverable

Improving Global Supply Chain Management (Semester Unknown) IPRO 306: ImprovingGlobalSupplyChainManagementIPRO306MidTermPresentationSp10

The IPRO 306 team will be working with a sanitation and janitorial equipment manufacturer, Sloan Valve. The core competency of this company lies in manufacturing flush valves. Sloan Valve is currently one of the leading producers of flush valves in the Northern American Continent. The team will be assisting Sloan Valve in realizing two major projects.Sponsorship: SLOANDeliverable

Improving Global Supply Chain Management (Semester Unknown) IPRO 306: ImprovingGlobalSupplyChainManagementIPRO306FinalPresentationSp10

The IPRO 306 team will be working with a sanitation and janitorial equipment manufacturer, Sloan Valve. The core competency of this company lies in manufacturing flush valves. Sloan Valve is currently one of the leading producers of flush valves in the Northern American Continent. The team will be assisting Sloan Valve in realizing two major projects.Sponsorship: SLOANDeliverable