Limb salvage therapy in septic diabetic foot ulcer in patients unwilling to undergo amputation

A clinical decision report appraising Shojaiefard A, Khorgami Z, Larijani B. Septic diabetic foot is not necessarily an indication for amputation. J Foot Ankle Surg. 2008;47(5):419-423. https://doi.org/10.1053/j.jfas.2008.05.005 for a patient with a septic diabetic foot

Does maternity leave affect child health? Evidence from parental leave in Australia survey

One of the arguments that is advanced in support of paid maternity leave (PML) policies is that the mother’s time away from work, around childbirth, is expected to improve maternal health and child health and development. However evidence on these links is scarce and, until recently, little was known about the link, if any, between child health and maternity leave. Moreover, the limited literature that does exist tends to use aggregate data (i.e., an “ecological design”) to test the hypotheses that maternity leave affects maternal and child health. Evidence from micro-level data is rare because of the unavailability of such data on household level. We employ such data from the Parental Leave in Australia Survey (PLAS), which is a nested survey of the Longitudinal Study of Australian Children (LSAC), to examine the impacts of maternity leave on child health. Using the PLAS and the first two waves of the LSAC we find that maternity leave, as measured by the duration of paid maternity leave (PML) and other forms of leave around childbirth, have strong and statistically significant effects on: child health, the decision to breastfeed, the duration of breastfeeding, and the probability that child immunisations are up-to-date. Our results show that mothers who take maternity leave are more likely to breastfeed their children and also that longer-term maternity leave is associated with an increase in the duration of breastfeeding. Our results also confirm that both mothers’ PML and fathers’ paid paternity leave (PPL) have statistically significant and positive effects on general health status of children. We also find that, in most specifications, the effects of PML are significant if the duration of leave is at least 6 weeks. PML is also significantly associated with a lower probability of some childhood chronic conditions such as asthma and bronchiolitis, but the effects of PPL on these conditions is ambiguous

Child Health and the Income Gradient: Evidence from Australia

The positive relationship between household income and child health is well documented in the child health literature but the precise mechanisms via which income generates better health and whether the income gradient is increasing in child age are not well understood. This paper presents new Australian evidence on the child health-income gradient. We use data from the Longitudinal Survey of Australian (LSAC), which involved two waves of data collection for children born between March 2003 and February 2004 (B-Cohort), and between March 1999 and February 2000 (K-Cohort). This data set allows us to test the robustness of some of the findings of the influential studies of Case et al. (2002) and J.Currie and Stabile (2003), and a recent study by A.Currie et al. (2007) , using a sample of Australian children. The richness of the LSAC data set also allows us to conduct further exploration of the determinants of child health. Our results reveal an increasing income gradient by child age using similar covariates to Case et al. (2002). However, the income gradient disappears if we include a rich set of controls. Our results indicate that parental health and, in particular, the mother's health plays a significant role, reducing the income coefficient to zero. Thus, our results for Australian children are similar to those produced by Propper et al. (2007) on their British child cohort. We also find some evidence that higher incomes have a protective effect when health shocks do arise: for several chronic conditions, children from higher-income households are less likely to be reported as being in poor health than children from lower-income households who have the same chronic conditions. The latter result is similar to some recent findings by Condliffe and Link (2008) on a sample of US children.Child health, Income gradient, Parental health, Nutrition, Panel data, Australia

A Novel Long-term, Multi-Channel and Non-invasive Electrophysiology Platform for Zebrafish.

Zebrafish are a popular vertebrate model for human neurological disorders and drug discovery. Although fecundity, breeding convenience, genetic homology and optical transparency have been key advantages, laborious and invasive procedures are required for electrophysiological studies. Using an electrode-integrated microfluidic system, here we demonstrate a novel multichannel electrophysiology unit to record multiple zebrafish. This platform allows spontaneous alignment of zebrafish and maintains, over days, close contact between head and multiple surface electrodes, enabling non-invasive long-term electroencephalographic recording. First, we demonstrate that electrographic seizure events, induced by pentylenetetrazole, can be reliably distinguished from eye or tail movement artifacts, and quantifiably identified with our unique algorithm. Second, we show long-term monitoring during epileptogenic progression in a scn1lab mutant recapitulating human Dravet syndrome. Third, we provide an example of cross-over pharmacology antiepileptic drug testing. Such promising features of this integrated microfluidic platform will greatly facilitate high-throughput drug screening and electrophysiological characterization of epileptic zebrafish

Rapid Optical Cavity PCR.

Recent outbreaks of deadly infectious diseases, such as Ebola and Middle East respiratory syndrome coronavirus, have motivated the research for accurate, rapid diagnostics that can be administered at the point of care. Nucleic acid biomarkers for these diseases can be amplified and quantified via polymerase chain reaction (PCR). In order to solve the problems of conventional PCR--speed, uniform heating and cooling, and massive metal heating blocks--an innovative optofluidic cavity PCR method using light-emitting diodes (LEDs) is accomplished. Using this device, 30 thermal cycles between 94 °C and 68 °C can be accomplished in 4 min for 1.3 μL (10 min for 10 μL). Simulation results show that temperature differences across the 750 μm thick cavity are less than 2 °C and 0.2 °C, respectively, at 94 °C and 68 °C. Nucleic acid concentrations as low as 10(-8) ng μL(-1) (2 DNA copies per μL) can be amplified with 40 PCR thermal cycles. This simple, ultrafast, precise, robust, and low-cost optofluidic cavity PCR is favorable for advanced molecular diagnostics and precision medicine. It is especially important for the development of lightweight, point-of-care devices for use in both developing and developed countries

Aspects of high density effective theory in QCD

We study an effective theory of QCD at high density in detail, including the finite temperature effects and the leading order correction in $1/\mu$ expansion. We investigate the Cooper pair gap equation and find that the color-flavor locking phase is energetically preferred at high density. We also find the color-superconducting phase transition occurs in dense quark matter when the chemical potential is larger than $250\pm 100~{\rm MeV}$ and the temperature is lower than 0.57 times the Cooper pair gap in the leading order in the hard-dense-loop approximation. The quark-neutrino four-Fermi coupling and the quark-axion coupling receive significant corrections in dense quark matter.Comment: 23 pages, 5 figures. The gap equations are re-analyzed in the HDL approximatio

Multiphase Equilibrium Behavior of the Mixture Carbon Dioxide + Ethane + Methanol

The Three-Phase Liquid-Liquid-Vapor (Llg) Phase Equilibrium Behavior of the Mixture Carbon Dioxide + Ethane + Methanol Was Experimentally Studied. the Boundaries of the Three-Phase Llg Region in Pressure-Temperature Space Are Delineated. Compositions and Molar Volumes of the Two Liquid Phases and the Vapor Phase Along the 288.15 and 298.15 K Isotherms Are Reported. © 1994, American Chemical Society. All Rights Reserved

Semantic Smart Homes: Towards Knowledge Rich Assisted Living Environments

International audienceThe complexity of the Emergency Supply Chains makes its management very difficult. Hence, we present in this article a comprehensive view of the French emergency supply chain (ESC), we propose an ad hoc relationship model between actors, and a GRAI grid-based model to initiate a new approach for controlling the ESC deficiencies, especially related to decision making. Throughout the article, we discuss the interest of the use of enterprise modelling to model the ESC. We discuss too, the characterization of the different issues related to the steering of the ESC. A literature review based on the GRAI grid model is proposed and discussed too. The GRAI method is used here because it presents the advantage of using the theory of complex systems, and it provides a dynamic model of an organization by focusing on decision-making and decisions communication

Edinburgh Clinical NLP at SemEval-2024 Task 2:Fine-tune your model unless you have access to GPT-4

The NLI4CT task assesses Natural Language Inference systems in predicting whether hypotheses entail or contradict evidence from Clinical Trial Reports. In this study, we evaluate various Large Language Models (LLMs) with multiple strategies, including Chain-of-Thought, In-Context Learning, and Parameter-Efficient Fine-Tuning (PEFT). We propose a PEFT method to improve the consistency of LLMs by merging adapters that were fine-tuned separately using triplet and language modelling objectives. We found that merging the two PEFT adapters improves the F1 score (+0.0346) and consistency (+0.152) of the LLMs. However, our novel methods did not produce more accurate results than GPT-4 in terms of faithfulness and consistency. Averaging the three metrics, GPT-4 ranks joint-first in the competition with 0.8328. Finally, our contamination analysis with GPT-4 indicates that there was no test data leakage