Explorations in price (un)fairness.

Consumers may use multiple reference points-including cost of goods, past prices, and competitive prices-to judge price fairness. Across a series of studies we show that consumers are inclined to overestimate profits, often to an extreme extent. We further demonstrate that prices are perceived to be unfair because consumers fail to take into account vendor costs, underestimate the effects of inflation, and attribute competitive price differences to profits. Potential corrective interventions by marketers-such as cueing costs, providing historical price information, and explaining price differences-were insufficient to eliminate unfairness perceptions. In addition, prices for goods were found to be stickier than prices for services and therefore were especially susceptible to these systematic perceptions of unfairness.Prices; Studies; Costs; Effects;

Beyond progressive liberalism and cultural relativism: Towards critical postmodernist, sociohistorically situated perspectives in classroom studies

In this paper we propose that classroom studies in the TESOL field tend to subscribe to either of the following two normative orders: (a) progressive liberalism, and (b) cultural relativism, without reflexively recognizing and meta-analysing these normative frameworks and their social, historical, and political situatedness. Drawing on Foucault's (1981) methods of historical excavation, we attempt a critical analysis of the socio-historical situatedness of these modernist normative orders. By building on relational analysis from critical educational studies (Apple, 1999), critical ethnography (Canagarajah, 1993; Chick, 1996; Kumaravadivelu, 1999; Pennycook, 2001), and the theory and method of articulation from cultural studies (Slack, 1996), we propose critical postmodernist, socio-historically situated perspectives in classroom studies and educational research as alternatives that break away from the modernist determinism of reproduction theories on the one hand, and radical postmodernist relativism on the other. We illustrate how such perspectives can contribute to our understanding of classroom practices with two classroom examples from Hong Kong schools, and we attempt to show the potential of these perspectives for contributing to the opening up of possibilities for change.postprin

Beyond progressive liberalism and cultural relativism: Towards critical postmodernist, sociohistorically situated perspectives in classroom studies

In this paper we propose that classroom studies in the TESOL field tend to subscribe to either of the following two normative orders: (a) progressive liberalism, and (b) cultural relativism, without reflexively recognizing and meta-analysing these normative frameworks and their social, historical, and political situatedness. Drawing on Foucault's (1981) methods of historical excavation, we attempt a critical analysis of the socio-historical situatedness of these modernist normative orders. By building on relational analysis from critical educational studies (Apple, 1999), critical ethnography (Canagarajah, 1993; Chick, 1996; Kumaravadivelu, 1999; Pennycook, 2001), and the theory and method of articulation from cultural studies (Slack, 1996), we propose critical postmodernist, socio-historically situated perspectives in classroom studies and educational research as alternatives that break away from the modernist determinism of reproduction theories on the one hand, and radical postmodernist relativism on the other. We illustrate how such perspectives can contribute to our understanding of classroom practices with two classroom examples from Hong Kong schools, and we attempt to show the potential of these perspectives for contributing to the opening up of possibilities for change.postprin

Are patterns of lumbar disc degeneration associated with low back pain? New insights based on skipped level disc pathology

Free Papers: Spine ‐ Lumbar: abstract no. 29648INTRODUCTION: The clinical relevance of 'patterns' of disc degeneration of the lumbar spine is unknown. In the setting of multilevel disc degeneration (2 or more levels), this study addressed the clinical implications of skipped level disc degeneration (SLDD) to that of consecutive, multilevel disc degeneration (CMDD) of the lumbar ...poatprin

Structure-Function Relationship in Healthy and Myelopathic Spinal Cord: A Combined Diffusion Tensor Imaging and Functional MR Imaging Study

Poster Presentation: P7 - Spinepublished_or_final_versio

FPGA acceleration of reference-based compression for genomic data

One of the key challenges facing genomics today is efficiently storing the massive amounts of data generated by next-generation sequencing platforms. Reference-based compression is a popular strategy for reducing the size of genomic data, whereby sequence information is encoded as a mapping to a known reference sequence. Determining the mapping is a computationally intensive problem, and is the bottleneck of most reference-based compression tools currently available. This paper presents the first FPGA acceleration of reference-based compression for genomic data. We develop a new mapping algorithm based on the FM-index search operation which includes optimisations targeting the compression ratio and speed. Our hardware design is implemented on a Maxeler MPC-X2000 node comprising 8 Altera Stratix V FPGAs. When evaluated against compression tools currently available, our tool achieves a superior compression ratio, compression time, and energy consumption for both FASTA and FASTQ formats. For example, our tool achieves a 30% higher compression ratio and is 71.9 times faster than the fastqz tool

Parallelisation of sequential Monte Carlo for real-time control in air traffic management

This paper presents the parallelisation of a Sequential Monte Carlo algorithm, and the associated changes required when applied to the problem of conflict resolution and aircraft trajectory control in air traffic management. The target problem is non-linear, constrained, non-convex and multi-agent. The new method is shown to have a 98.5% computational time saving over that of a previous sequential implementation, with no degradation in path quality. The computation saving is enough to allow real-time implementation.This work was supported by EPSRC (Engineering and Physical Sciences Research Council - UK) Grant No. EP/G066477/1In proceedings of the IEEE Conference on Decision and Control 201

Microparticles mediate the intercellular regulation of microRNA-503 and proline-rich tyrosine kinase 2 to alter the migration and invasion capacity of breast cancer cells

The successful treatment of cancer is hampered by drug resistance and metastasis. While these two obstacles were once considered separately, recent evidence associates resistance with an enhanced metastatic capacity. However, the underlying mechanisms remain undefined. We previously described the intercellular transfer of drug resistance via submicron vesicles called microparticles (MPs). We now propose that MPs derived from drug-resistant cells are also involved in the intercellular transfer of components to enhance the migration and invasion capacity of cells. Thus, MPs may be a conduit between resistance and metastasis. We used microarray analysis to identify regulatory microRNAs (miRNAs), which contribute to the dissemination of metastatic traits. miR-503 was downregulated in recipient cells following co-culture with MPs isolated from drug-resistant cells. miR-503 was inversely associated with metastasis, as demonstrated using wound healing/scratch migration assays and Matrigel®-coated transwell invasion assays. Proline-rich tyrosine kinase 2 (PYK2) was upregulated in recipient cells and associated with increased migration and invasion, with these phenotypes being reversed using a pharmacological inhibitor of PYK2 phosphorylation, tyrphostin A9. However, the MP-mediated promotion of metastatic traits was not due to the presence of these effectors in the MP cargo but rather due to down stream effector molecules in these pathways. This is the first demonstration that the role of MPs in trait acquisition extends beyond the direct transfer of vesicle components and also includes transfer of intermediary regulators that induce down stream mediators following transfer to recipient cells. This implicates an expanding role of MPs in cancer pathogenesis. © 2014 Gong, Luk, Jaiswal and Bebawy