Cobb's collar and chronic renal failure

Pontificia Univ Catolica Campinas, Campinas, SP, BrazilUniv Fed Sao Paulo, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Sao Paulo, SP, BrazilWeb of Scienc

Divertículo caliceal gigante: relato de caso

Este relato de caso aborda uma paciente de 68 anos com queixa de hematúria. Ela foi diagnosticada com divertículo caliceal, uma cavidade cística rara e congênita no parênquima renal. Em muitos casos, os divertículos são assintomáticos, mas em alguns podem causar sintomas, como dor, infecções urinárias e formação de cálculos. O tratamento varia de acordo com a topografia do divertículo e da anatomia do paciente e pode ser realizado de maneira invasiva ou não-invasiva. A decisão sobre o tratamento é baseada em múltiplas variáveis e deve ser avaliada pela equipe responsável

Gestão de Gravidez de Alto Risco: Estratégias Clínicas e Resultados Materno-Infantis

Objective: The article analyzes the management of high-risk pregnancies, addressing clinical strategies, medical innovations, ethical challenges, and socioeconomic impact. It aims to provide a comprehensive understanding of the topic by integrating technological, cultural, and ethical aspects to inform healthcare professionals and researchers about advances in obstetrics. Methodology: The article employed a comprehensive review methodology, analyzing studies on the management of high-risk pregnancies, covering clinical aspects, medical innovations, ethical challenges, and socioeconomic impact. The integration of technological, cultural, and ethical data aimed to offer a complete view of the subject for healthcare professionals and researchers. Results: The results highlight clinical approaches, medical innovations, and ethical challenges in managing high-risk pregnancies. Socioeconomic impact is considered, and future perspectives include the pursuit of equity in healthcare access. The article aims to inform professionals and researchers about the complexities and advancements in obstetrics. Conclusion: Managing high-risk pregnancies requires a balance between medical innovations, ethics, and equitable healthcare access. Emphasizing education and prevention empowers women, while the future emphasizes a patient-centered approach to mitigate risks and ensure positive experiences for families.Objetivo: O artigo analisa a gestão de gravidezes de alto risco, abordando estratégias clínicas, inovações médicas, desafios éticos e o impacto socioeconômico. Busca oferecer uma compreensão abrangente do tema, integrando aspectos tecnológicos, culturais e éticos para informar profissionais de saúde e pesquisadores sobre avanços na obstetrícia. Metodologia: O artigo adotou uma metodologia de revisão abrangente, analisando estudos sobre a gestão de gravidezes de alto risco, abordando aspectos clínicos, inovações médicas, desafios éticos e impacto socioeconômico. A integração de dados tecnológicos, culturais e éticos visou proporcionar uma visão completa do tema para profissionais de saúde e pesquisadores. Resultados: Os resultados destacam abordagens clínicas, inovações médicas e desafios éticos na gestão de gravidezes de alto risco. O impacto socioeconômico é considerado, e perspectivas futuras incluem a busca por equidade no acesso à saúde. O artigo visa informar profissionais e pesquisadores sobre complexidades e avanços nesse campo obstétrico. Conclusão: A gestão de gravidezes de alto risco exige equilíbrio entre inovações médicas, ética e acesso equitativo à saúde. A ênfase na educação e prevenção capacita as mulheres, enquanto o futuro destaca uma abordagem centrada na paciente para mitigar riscos e garantir experiências positivas para as famílias

Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.  Methodology/Principal Findings: The T. rangeli haploid genome is ,24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heatshock proteins.  Conclusions/Significance: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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The Genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s)

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ