Extended Development of Variable Conductance Heat Pipes

A high-capacity vapor-modulated heat pipe was designed and tested. In 1977, a program was undertaken to use the aforementioned heat pipe to study protection from freezing-point failure, increase control sensitivity, and transient behavior under a wide range of operating conditions in order to determine the full performance potential of the heat pipe. A new concept, based on the vapor-induced-dry-out principle, was developed for passive feedback temperature control as a heat pipe diode. This report documents this work and describes: (1) the experimental and theoretical investigation of the performance of the vapor-modulated heat pipe; and (2) the design, fabrication and test of the heat pipe diode

It All Started With a Button…

As librarians at an art and design library that is also part of a larger institution, we find it necessary to continually come up with new and innovative ways to make our library a welcoming, appealing, interesting and relevant place. Of particular popularity are the buttons we make using images from resources available at the library. For outreach, we give them away at every opportunity, including orientations (while wearing the “librarian” t-shirts we made) and faculty meetings. We also use them as teaching tools, and as incentive for participation in library instruction sessions. Our student workers and staff members have a range of talents and interests that can be maximized to promote the library as well. We encourage librarians in other settings to expand on our ideas and use the resources at hand for creative library promotion and marketing projects

An investigation of the thermal radiation properties of certain spacecraft materials Final report

Thermal radiation analysis for anodized aluminum - anodizing process evaluation for optimum properties under space conditions for spacecraft temperature contro

SAFETY PERFORMANCE EVALUATION OF THE STEEL-BACKED LOG RAIL

The Coordinated Federal Lands Highways Technology Improvement Program (CTIP) was developed with the purpose of serving the immediate needs of those who design and construct Federal Lands Highways, including Indian Reservation roads, National Park roads and parkways, and forest highways. A wide assortment of guardrails, bridge rails and transitions are being used on roads under the jurisdiction of the National Park Service and other Federal agencies. These guardrails, bridge rails and transitions are intended to blend in with the roadside in order to preserve the visual integrity of the parks and parkways. However, many of them have never been crash tested (1,2). A testing program was developed in order to ensure that the safety hardware used in these areas are safe for the traveling public. The Steel Backed Log Rail was included in the second Federal Highway Administration (FHWA) testing program - Guardrail Testing Program II

Oxytocin in the Circadian Timing of Birth

BACKGROUND: The molecular components determining the timing for birth remain an incompletely characterized aspect of reproduction, with important conceptual and therapeutic ramifications for management of preterm, post-term and arrested labor. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis that oxytocin mediates circadian regulation of birth, we evaluated parturition timing following shifts in light cycles in oxytocin (OT)-deficient mice. We find that, in contrast to wild type mice that do not shift the timing of birth following a 6-h advance or delay in the light cycle, OT-deficient mice delivered at random times of day. Moreover, shifts in the light-dark cycle of gravid wild type mice have little impact on the pattern of circadian oxytocin release. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate oxytocin plays a critical role in minimizing labor disruption due to circadian clock resetting

Gemcitabine and vinorelbine followed by docetaxel in patients with advanced non-small-cell lung cancer: a multi-institutional phase II trial of nonplatinum sequential triplet combination chemotherapy (JMTO LC00-02)

To evaluate the efficacy and toxicity of the sequential nonplatinum combination chemotherapy consisting of gemcitabine (GEM) and vinorelbine (VNR) followed by docetaxel (DOC) in patients with advanced non-small-cell lung cancer (NSCLC), we conducted the multiinstitutional phase II study. A total of 44 chemotherapy-naive patients with advanced NSCLC were treated with GEM 1000 mg m−2 and VNR 25 mg m−2 intravenously on days 1 and 8 every 3 weeks for three cycles. DOC 60 mg m−2 was then administrated intravenously at 3-week intervals for three cycles. Patients were evaluated for response and toxicity with each cycle of the treatment. The major objective response rate was 47.7% (95% confidence interval (CI), 33.8–62.1%). Median survival time (MST) was 15.7 months and 1-year survival rate was 59%. In the GEM/VNR cycle, grade 3/4 neutropenia occurred in 36.3%, grade 3/4 anaemia in two patients (4.5%) and grade 3 thrombocytopenia in one patient (2.3%). Grade 3 pneumonitis occurred in two patients (4.5%) in GEM/VNR cycles. In the DOC cycles, grade 3/4 neutropenia occurred in 39.4% but no patient experienced grade 3/4 anaemia or thrombocytopenia. Of the 44 eligible patients, 33 patients completed three cycles of GEM/VNR and 22 patients completed six cycles of planned chemotherapy (three cycles of GEM/VNR followed by three cycles of DOC). The sequential triplet nonplatinum chemotherapy consisted of GEM/VNR followed by DOC, and was very active and well tolerated. This study forms the basis for an ongoing phase III trial that compares this nonplatinum triplet and standard platinum doublet combination (carboplatin/paclitaxel)

Potential role of ticks as vectors of bluetongue virus

When the first outbreak of bluetongue virus serotype 8 (BTV8) was recorded in North-West Europe in August 2006 and renewed outbreaks occurred in the summer of 2007 and again in 2008, the question was raised how the virus survived the winter. Since most adult Culicoides vector midges are assumed not to survive the northern European winter, and transovarial transmission in Culicoides is not recorded, we examined the potential vector role of ixodid and argasid ticks for bluetongue virus. Four species of ixodid ticks (Ixodes ricinus, Ixodes hexagonus, Dermacentor reticulatus and Rhipicephalus bursa) and one soft tick species, Ornithodoros savignyi, ingested BTV8-containing blood either through capillary feeding or by feeding on artificial membranes. The virus was taken up by the ticks and was found to pass through the gut barrier and spread via the haemolymph into the salivary glands, ovaries and testes, as demonstrated by real-time reverse transcriptase PCR (PCR-test). BTV8 was detected in various tissues of ixodid ticks for up to 21 days post feeding and in Ornithodoros ticks for up to 26 days. It was found after moulting in adult Ixodes hexagonus and was also able to pass through the ovaries into the eggs of an Ornithodoros savignyi tick. This study demonstrates that ticks can become infected with bluetongue virus serotype 8. The transstadial passage in hard ticks and transovarial passage in soft ticks suggest that ticks have potential vectorial capacity for bluetongue virus. Further studies are required to investigate transmission from infected ticks to domestic livestock. This route of transmission could provide an additional clue in the unresolved mystery of the epidemiology of Bluetongue in Europe by considering ticks as a potential overwintering mechanism for bluetongue virus